GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.
Identifieur interne : 004464 ( Ncbi/Curation ); précédent : 004463; suivant : 004465GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.
Auteurs : Ignacio F. Mata [États-Unis] ; James B. Leverenz [États-Unis] ; Daniel Weintraub [États-Unis] ; John Q. Trojanowski [États-Unis] ; Alice Chen-Plotkin [États-Unis] ; Vivianna M. Van Deerlin [États-Unis] ; Beate Ritz [États-Unis] ; Rebecca Rausch [États-Unis] ; Stewart A. Factor [États-Unis] ; Cathy Wood-Siverio [États-Unis] ; Joseph F. Quinn [États-Unis] ; Kathryn A. Chung [États-Unis] ; Amie L. Peterson-Hiller [États-Unis] ; Jennifer G. Goldman [États-Unis] ; Glenn T. Stebbins [États-Unis] ; Bryan Bernard [États-Unis] ; Alberto J. Espay [États-Unis] ; Fredy J. Revilla [États-Unis] ; Johnna Devoto [États-Unis] ; Liana S. Rosenthal [États-Unis] ; Ted M. Dawson [États-Unis] ; Marilyn S. Albert [États-Unis] ; Debby Tsuang [États-Unis] ; Haley Huston [États-Unis] ; Dora Yearout [États-Unis] ; Shu-Ching Hu [États-Unis] ; Brenna A. Cholerton [États-Unis] ; Thomas J. Montine [États-Unis] ; Karen L. Edwards [États-Unis] ; Cyrus P. Zabetian [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.
DOI: 10.1002/mds.26359
PubMed: 26296077
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<sourceDesc><biblStruct><analytic><title xml:lang="en">GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.</title>
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<author><name sortKey="Chen Plotkin, Alice" sort="Chen Plotkin, Alice" uniqKey="Chen Plotkin A" first="Alice" last="Chen-Plotkin">Alice Chen-Plotkin</name>
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</placeName>
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<author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name>
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<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
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<wicri:regionArea>Department of Epidemiology, School of Public Health, University of California Los Angeles, Los Angeles, California</wicri:regionArea>
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<author><name sortKey="Rausch, Rebecca" sort="Rausch, Rebecca" uniqKey="Rausch R" first="Rebecca" last="Rausch">Rebecca Rausch</name>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia</wicri:regionArea>
<placeName><region type="state">Géorgie (États-Unis)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F" last="Quinn">Joseph F. Quinn</name>
<affiliation wicri:level="2"><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
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</author>
<author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A" last="Chung">Kathryn A. Chung</name>
<affiliation wicri:level="2"><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peterson Hiller, Amie L" sort="Peterson Hiller, Amie L" uniqKey="Peterson Hiller A" first="Amie L" last="Peterson-Hiller">Amie L. Peterson-Hiller</name>
<affiliation wicri:level="2"><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Portland Veterans Affairs Medical Center, Portland, Oregon</wicri:regionArea>
<placeName><region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Goldman, Jennifer G" sort="Goldman, Jennifer G" uniqKey="Goldman J" first="Jennifer G" last="Goldman">Jennifer G. Goldman</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T" last="Stebbins">Glenn T. Stebbins</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bernard, Bryan" sort="Bernard, Bryan" uniqKey="Bernard B" first="Bryan" last="Bernard">Bryan Bernard</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Devoto, Johnna" sort="Devoto, Johnna" uniqKey="Devoto J" first="Johnna" last="Devoto">Johnna Devoto</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rosenthal, Liana S" sort="Rosenthal, Liana S" uniqKey="Rosenthal L" first="Liana S" last="Rosenthal">Liana S. Rosenthal</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M" last="Dawson">Ted M. Dawson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Albert, Marilyn S" sort="Albert, Marilyn S" uniqKey="Albert M" first="Marilyn S" last="Albert">Marilyn S. Albert</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tsuang, Debby" sort="Tsuang, Debby" uniqKey="Tsuang D" first="Debby" last="Tsuang">Debby Tsuang</name>
<affiliation wicri:level="2"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Puget Sound Health Care System, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huston, Haley" sort="Huston, Haley" uniqKey="Huston H" first="Haley" last="Huston">Haley Huston</name>
<affiliation wicri:level="2"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Puget Sound Health Care System, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<affiliation wicri:level="2"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Puget Sound Health Care System, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Shu Ching" sort="Hu, Shu Ching" uniqKey="Hu S" first="Shu-Ching" last="Hu">Shu-Ching Hu</name>
<affiliation wicri:level="2"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Puget Sound Health Care System, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cholerton, Brenna A" sort="Cholerton, Brenna A" uniqKey="Cholerton B" first="Brenna A" last="Cholerton">Brenna A. Cholerton</name>
<affiliation wicri:level="2"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Puget Sound Health Care System, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of Washington School of Medicine, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L" last="Edwards">Karen L. Edwards</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name>
<affiliation wicri:level="2"><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Puget Sound Health Care System, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.</div>
</front>
</TEI>
</record>
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