GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.
Identifieur interne : 000054 ( PubMed/Corpus ); précédent : 000053; suivant : 000055GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.
Auteurs : Ignacio F. Mata ; James B. Leverenz ; Daniel Weintraub ; John Q. Trojanowski ; Alice Chen-Plotkin ; Vivianna M. Van Deerlin ; Beate Ritz ; Rebecca Rausch ; Stewart A. Factor ; Cathy Wood-Siverio ; Joseph F. Quinn ; Kathryn A. Chung ; Amie L. Peterson-Hiller ; Jennifer G. Goldman ; Glenn T. Stebbins ; Bryan Bernard ; Alberto J. Espay ; Fredy J. Revilla ; Johnna Devoto ; Liana S. Rosenthal ; Ted M. Dawson ; Marilyn S. Albert ; Debby Tsuang ; Haley Huston ; Dora Yearout ; Shu-Ching Hu ; Brenna A. Cholerton ; Thomas J. Montine ; Karen L. Edwards ; Cyrus P. ZabetianSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.
DOI: 10.1002/mds.26359
PubMed: 26296077
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.</title>
<author><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F" last="Mata">Ignacio F. Mata</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B" last="Leverenz">James B. Leverenz</name>
<affiliation><nlm:affiliation>Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name>
<affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen Plotkin, Alice" sort="Chen Plotkin, Alice" uniqKey="Chen Plotkin A" first="Alice" last="Chen-Plotkin">Alice Chen-Plotkin</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name>
<affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health, University of California Los Angeles, Los Angeles, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rausch, Rebecca" sort="Rausch, Rebecca" uniqKey="Rausch R" first="Rebecca" last="Rausch">Rebecca Rausch</name>
<affiliation><nlm:affiliation>Department of Neurology, University of California Los Angeles, Los Angeles, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A" last="Factor">Stewart A. Factor</name>
<affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wood Siverio, Cathy" sort="Wood Siverio, Cathy" uniqKey="Wood Siverio C" first="Cathy" last="Wood-Siverio">Cathy Wood-Siverio</name>
<affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F" last="Quinn">Joseph F. Quinn</name>
<affiliation><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A" last="Chung">Kathryn A. Chung</name>
<affiliation><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peterson Hiller, Amie L" sort="Peterson Hiller, Amie L" uniqKey="Peterson Hiller A" first="Amie L" last="Peterson-Hiller">Amie L. Peterson-Hiller</name>
<affiliation><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goldman, Jennifer G" sort="Goldman, Jennifer G" uniqKey="Goldman J" first="Jennifer G" last="Goldman">Jennifer G. Goldman</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T" last="Stebbins">Glenn T. Stebbins</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bernard, Bryan" sort="Bernard, Bryan" uniqKey="Bernard B" first="Bryan" last="Bernard">Bryan Bernard</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name>
<affiliation><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name>
<affiliation><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Devoto, Johnna" sort="Devoto, Johnna" uniqKey="Devoto J" first="Johnna" last="Devoto">Johnna Devoto</name>
<affiliation><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rosenthal, Liana S" sort="Rosenthal, Liana S" uniqKey="Rosenthal L" first="Liana S" last="Rosenthal">Liana S. Rosenthal</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M" last="Dawson">Ted M. Dawson</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Albert, Marilyn S" sort="Albert, Marilyn S" uniqKey="Albert M" first="Marilyn S" last="Albert">Marilyn S. Albert</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tsuang, Debby" sort="Tsuang, Debby" uniqKey="Tsuang D" first="Debby" last="Tsuang">Debby Tsuang</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huston, Haley" sort="Huston, Haley" uniqKey="Huston H" first="Haley" last="Huston">Haley Huston</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hu, Shu Ching" sort="Hu, Shu Ching" uniqKey="Hu S" first="Shu-Ching" last="Hu">Shu-Ching Hu</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cholerton, Brenna A" sort="Cholerton, Brenna A" uniqKey="Cholerton B" first="Brenna A" last="Cholerton">Brenna A. Cholerton</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L" last="Edwards">Karen L. Edwards</name>
<affiliation><nlm:affiliation>Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
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<idno type="doi">10.1002/mds.26359</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.</title>
<author><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F" last="Mata">Ignacio F. Mata</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leverenz, James B" sort="Leverenz, James B" uniqKey="Leverenz J" first="James B" last="Leverenz">James B. Leverenz</name>
<affiliation><nlm:affiliation>Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q" last="Trojanowski">John Q. Trojanowski</name>
<affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen Plotkin, Alice" sort="Chen Plotkin, Alice" uniqKey="Chen Plotkin A" first="Alice" last="Chen-Plotkin">Alice Chen-Plotkin</name>
<affiliation><nlm:affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna M" last="Van Deerlin">Vivianna M. Van Deerlin</name>
<affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ritz, Beate" sort="Ritz, Beate" uniqKey="Ritz B" first="Beate" last="Ritz">Beate Ritz</name>
<affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health, University of California Los Angeles, Los Angeles, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rausch, Rebecca" sort="Rausch, Rebecca" uniqKey="Rausch R" first="Rebecca" last="Rausch">Rebecca Rausch</name>
<affiliation><nlm:affiliation>Department of Neurology, University of California Los Angeles, Los Angeles, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart A" last="Factor">Stewart A. Factor</name>
<affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wood Siverio, Cathy" sort="Wood Siverio, Cathy" uniqKey="Wood Siverio C" first="Cathy" last="Wood-Siverio">Cathy Wood-Siverio</name>
<affiliation><nlm:affiliation>Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph F" last="Quinn">Joseph F. Quinn</name>
<affiliation><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn A" last="Chung">Kathryn A. Chung</name>
<affiliation><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peterson Hiller, Amie L" sort="Peterson Hiller, Amie L" uniqKey="Peterson Hiller A" first="Amie L" last="Peterson-Hiller">Amie L. Peterson-Hiller</name>
<affiliation><nlm:affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goldman, Jennifer G" sort="Goldman, Jennifer G" uniqKey="Goldman J" first="Jennifer G" last="Goldman">Jennifer G. Goldman</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stebbins, Glenn T" sort="Stebbins, Glenn T" uniqKey="Stebbins G" first="Glenn T" last="Stebbins">Glenn T. Stebbins</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bernard, Bryan" sort="Bernard, Bryan" uniqKey="Bernard B" first="Bryan" last="Bernard">Bryan Bernard</name>
<affiliation><nlm:affiliation>Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Espay, Alberto J" sort="Espay, Alberto J" uniqKey="Espay A" first="Alberto J" last="Espay">Alberto J. Espay</name>
<affiliation><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Revilla, Fredy J" sort="Revilla, Fredy J" uniqKey="Revilla F" first="Fredy J" last="Revilla">Fredy J. Revilla</name>
<affiliation><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Devoto, Johnna" sort="Devoto, Johnna" uniqKey="Devoto J" first="Johnna" last="Devoto">Johnna Devoto</name>
<affiliation><nlm:affiliation>Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, Ohio, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rosenthal, Liana S" sort="Rosenthal, Liana S" uniqKey="Rosenthal L" first="Liana S" last="Rosenthal">Liana S. Rosenthal</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dawson, Ted M" sort="Dawson, Ted M" uniqKey="Dawson T" first="Ted M" last="Dawson">Ted M. Dawson</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Albert, Marilyn S" sort="Albert, Marilyn S" uniqKey="Albert M" first="Marilyn S" last="Albert">Marilyn S. Albert</name>
<affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tsuang, Debby" sort="Tsuang, Debby" uniqKey="Tsuang D" first="Debby" last="Tsuang">Debby Tsuang</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Huston, Haley" sort="Huston, Haley" uniqKey="Huston H" first="Haley" last="Huston">Haley Huston</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hu, Shu Ching" sort="Hu, Shu Ching" uniqKey="Hu S" first="Shu-Ching" last="Hu">Shu-Ching Hu</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cholerton, Brenna A" sort="Cholerton, Brenna A" uniqKey="Cholerton B" first="Brenna A" last="Cholerton">Brenna A. Cholerton</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas J" last="Montine">Thomas J. Montine</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Edwards, Karen L" sort="Edwards, Karen L" uniqKey="Edwards K" first="Karen L" last="Edwards">Karen L. Edwards</name>
<affiliation><nlm:affiliation>Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P" last="Zabetian">Cyrus P. Zabetian</name>
<affiliation><nlm:affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">26296077</PMID>
<DateCreated><Year>2015</Year>
<Month>8</Month>
<Day>21</Day>
</DateCreated>
<DateRevised><Year>2015</Year>
<Month>9</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><PubDate><Year>2015</Year>
<Month>Aug</Month>
<Day>21</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn></MedlinePgn>
</Pagination>
<ELocationID EIdType="doi">10.1002/mds.26359</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We screened the GBA coding region for mutations and the E326K polymorphism in 1,369 PD patients enrolled at eight sites from the PD Cognitive Genetics Consortium. Participants underwent assessments of learning and memory (Hopkins Verbal Learning Test-Revised), working memory/executive function (Letter-Number Sequencing Test and Trail Making Test A and B), language processing (semantic and phonemic verbal fluency), visuospatial abilities (Benton Judgment of Line Orientation), and global cognitive function (MoCA). We used linear regression to test for association between genotype and cognitive performance with adjustment for important covariates and accounted for multiple testing using Bonferroni's corrections.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Mutation carriers (n = 60; 4.4%) and E326K carriers (n = 65; 4.7%) had a higher prevalence of dementia (mutations, odds ratio = 5.1; P = 9.7 × 10(-6) ; E326K, odds ratio = 6.4; P = 5.7 × 10(-7) ) and lower performance on Letter-Number Sequencing (mutations, corrected P[Pc ] = 9.0 × 10(-4) ; E326K, Pc = 0.036), Trail Making B-A (mutations, Pc = 0.018; E326K, Pc = 0.018), and Benton Judgment of Line Orientation (mutations, Pc = 0.0045; E326K, Pc = 0.0013).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Both GBA mutations and E326K are associated with a distinct cognitive profile characterized by greater impairment in working memory/executive function and visuospatial abilities in PD patients. The discovery that E326K negatively impacts cognitive performance approximately doubles the proportion of PD patients we now recognize are at risk for more severe GBA-related cognitive deficits. © 2015 International Parkinson and Movement Disorder Society.</AbstractText>
<CopyrightInformation>© 2015 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList><Author><LastName>Mata</LastName>
<ForeName>Ignacio F</ForeName>
<Initials>IF</Initials>
<AffiliationInfo><Affiliation>Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Leverenz</LastName>
<ForeName>James B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo><Affiliation>Lou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Weintraub</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Trojanowski</LastName>
<ForeName>John Q</ForeName>
<Initials>JQ</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Chen-Plotkin</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author><LastName>Van Deerlin</LastName>
<ForeName>Vivianna M</ForeName>
<Initials>VM</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.</Affiliation>
</AffiliationInfo>
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<AffiliationInfo><Affiliation>Department of Environmental Health Sciences, School of Public Health, University of California Los Angeles, Los Angeles, California, USA.</Affiliation>
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