Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.
Identifieur interne : 002C31 ( Ncbi/Curation ); précédent : 002C30; suivant : 002C32Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.
Auteurs : Sigurd D. Süssmuth [Allemagne] ; Ingo Uttner ; Bernhard Landwehrmeyer ; Elmar H. Pinkhardt ; Johannes Brettschneider ; Axel Petzold ; Bernd Kramer ; Jörg B. Schulz ; Christian Palm ; Markus Otto ; Albert C. Ludolph ; Jan Kassubek ; Hayrettin TumaniSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Amyloid beta-Peptides (cerebrospinal fluid), Female, Glial Fibrillary Acidic Protein (cerebrospinal fluid), Humans, Male, Middle Aged, Parkinsonian Disorders (cerebrospinal fluid), Peptide Fragments (cerebrospinal fluid), Statistics, Nonparametric, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Amyloid beta-Peptides, Glial Fibrillary Acidic Protein, Peptide Fragments, tau Proteins.
- cerebrospinal fluid : Parkinsonian Disorders.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (Abeta1-42), Abeta1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P
DOI: 10.1002/mds.22895
PubMed: 20589870
DOI: 10.1002/mds.22895
PubMed: 20589870
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pubmed:20589870Le document en format XML
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Süssmuth</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Uttner, Ingo" sort="Uttner, Ingo" uniqKey="Uttner I" first="Ingo" last="Uttner">Ingo Uttner</name></author><author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name></author><author><name sortKey="Pinkhardt, Elmar H" sort="Pinkhardt, Elmar H" uniqKey="Pinkhardt E" first="Elmar H" last="Pinkhardt">Elmar H. Pinkhardt</name></author><author><name sortKey="Brettschneider, Johannes" sort="Brettschneider, Johannes" uniqKey="Brettschneider J" first="Johannes" last="Brettschneider">Johannes Brettschneider</name></author><author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name></author><author><name sortKey="Kramer, Bernd" sort="Kramer, Bernd" uniqKey="Kramer B" first="Bernd" last="Kramer">Bernd Kramer</name></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B" last="Schulz">Jörg B. Schulz</name></author><author><name sortKey="Palm, Christian" sort="Palm, Christian" uniqKey="Palm C" first="Christian" last="Palm">Christian Palm</name></author><author><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name></author><author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name></author><author><name sortKey="Tumani, Hayrettin" sort="Tumani, Hayrettin" uniqKey="Tumani H" first="Hayrettin" last="Tumani">Hayrettin Tumani</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22895</idno><idno type="RBID">pubmed:20589870</idno><idno type="pmid">20589870</idno><idno type="wicri:Area/PubMed/Corpus">001786</idno><idno type="wicri:Area/PubMed/Curation">001786</idno><idno type="wicri:Area/PubMed/Checkpoint">001940</idno><idno type="wicri:Area/Ncbi/Merge">002C31</idno><idno type="wicri:Area/Ncbi/Curation">002C31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.</title><author><name sortKey="Sussmuth, Sigurd D" sort="Sussmuth, Sigurd D" uniqKey="Sussmuth S" first="Sigurd D" last="Süssmuth">Sigurd D. Süssmuth</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, University of Ulm, Ulm, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, University of Ulm, Ulm</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Ulm</settlement></placeName><orgName type="university">Université d'Ulm</orgName></affiliation></author><author><name sortKey="Uttner, Ingo" sort="Uttner, Ingo" uniqKey="Uttner I" first="Ingo" last="Uttner">Ingo Uttner</name></author><author><name sortKey="Landwehrmeyer, Bernhard" sort="Landwehrmeyer, Bernhard" uniqKey="Landwehrmeyer B" first="Bernhard" last="Landwehrmeyer">Bernhard Landwehrmeyer</name></author><author><name sortKey="Pinkhardt, Elmar H" sort="Pinkhardt, Elmar H" uniqKey="Pinkhardt E" first="Elmar H" last="Pinkhardt">Elmar H. Pinkhardt</name></author><author><name sortKey="Brettschneider, Johannes" sort="Brettschneider, Johannes" uniqKey="Brettschneider J" first="Johannes" last="Brettschneider">Johannes Brettschneider</name></author><author><name sortKey="Petzold, Axel" sort="Petzold, Axel" uniqKey="Petzold A" first="Axel" last="Petzold">Axel Petzold</name></author><author><name sortKey="Kramer, Bernd" sort="Kramer, Bernd" uniqKey="Kramer B" first="Bernd" last="Kramer">Bernd Kramer</name></author><author><name sortKey="Schulz, Jorg B" sort="Schulz, Jorg B" uniqKey="Schulz J" first="Jörg B" last="Schulz">Jörg B. Schulz</name></author><author><name sortKey="Palm, Christian" sort="Palm, Christian" uniqKey="Palm C" first="Christian" last="Palm">Christian Palm</name></author><author><name sortKey="Otto, Markus" sort="Otto, Markus" uniqKey="Otto M" first="Markus" last="Otto">Markus Otto</name></author><author><name sortKey="Ludolph, Albert C" sort="Ludolph, Albert C" uniqKey="Ludolph A" first="Albert C" last="Ludolph">Albert C. Ludolph</name></author><author><name sortKey="Kassubek, Jan" sort="Kassubek, Jan" uniqKey="Kassubek J" first="Jan" last="Kassubek">Jan Kassubek</name></author><author><name sortKey="Tumani, Hayrettin" sort="Tumani, Hayrettin" uniqKey="Tumani H" first="Hayrettin" last="Tumani">Hayrettin Tumani</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Amyloid beta-Peptides (cerebrospinal fluid)</term><term>Female</term><term>Glial Fibrillary Acidic Protein (cerebrospinal fluid)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinsonian Disorders (cerebrospinal fluid)</term><term>Peptide Fragments (cerebrospinal fluid)</term><term>Statistics, Nonparametric</term><term>tau Proteins (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Amyloid beta-Peptides</term><term>Glial Fibrillary Acidic Protein</term><term>Peptide Fragments</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (Abeta1-42), Abeta1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P </div> </front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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