Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.
Identifieur interne : 001940 ( PubMed/Checkpoint ); précédent : 001939; suivant : 001941Differential pattern of brain-specific CSF proteins tau and amyloid-β in Parkinsonian syndromes.
Auteurs : Sigurd D. Süssmuth [Allemagne] ; Ingo Uttner ; Bernhard Landwehrmeyer ; Elmar H. Pinkhardt ; Johannes Brettschneider ; Axel Petzold ; Bernd Kramer ; Jörg B. Schulz ; Christian Palm ; Markus Otto ; Albert C. Ludolph ; Jan Kassubek ; Hayrettin TumaniSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Amyloid beta-Peptides (cerebrospinal fluid), Female, Glial Fibrillary Acidic Protein (cerebrospinal fluid), Humans, Male, Middle Aged, Parkinsonian Disorders (cerebrospinal fluid), Peptide Fragments (cerebrospinal fluid), Statistics, Nonparametric, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Amyloid beta-Peptides, Glial Fibrillary Acidic Protein, Peptide Fragments, tau Proteins.
- cerebrospinal fluid : Parkinsonian Disorders.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Statistics, Nonparametric.
Abstract
To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (Abeta1-42), Abeta1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P
DOI: 10.1002/mds.22895
PubMed: 20589870
DOI: 10.1002/mds.22895
PubMed: 20589870
Affiliations:
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Links to Exploration step
pubmed:20589870Le document en format XML
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<front><div type="abstract" xml:lang="en">To evaluate cerebrospinal fluid (CSF) proteins reflecting processes of neurodegeneration and glial activation in progressive supranuclear palsy (PSP; Richardson's syndrome, n = 20; PSP-Parkinsonism, n = 7) and multiple system atrophy (MSA, n = 25), we analyzed tau, phosphorylated tau, amyloid-beta(1-42) (Abeta1-42), Abeta1-40, glial fibrillary acidic protein (GFAP), and CSF routine variables. Individuals with PSP-Parkinsonism and MSA had elevated tau levels when compared with Richardson's syndrome, Parkinson's disease (PD), and age-matched controls (P </div>
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