Perceived imbalance and risk of Parkinson’s disease
Identifieur interne : 002023 ( Ncbi/Curation ); précédent : 002022; suivant : 002024Perceived imbalance and risk of Parkinson’s disease
Auteurs : Xiang Gao ; Honglei Chen ; Michael A. Schwarzschild ; Giancarlo Logroscino ; Alberto AscherioSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease.
- physiology : Postural Balance.
- physiopathology : Parkinson Disease.
- Adult, Attitude to Health, Awareness, Diagnosis, Differential, Female, Follow-Up Studies, Health Status, Humans, Male, Middle Aged, Prospective Studies, Questionnaires, Risk Factors.
Abstract
We prospectively examined associations between perceived imbalance and Parkinson’s disease (PD) risk in the Health Professional Follow-up Study (HPFS), and Nurses’ Health Study (NHS). We included 39,087 men and 82,299 women free of PD at baseline (1990) in the current analyses. We documented 449 incident PD cases during 12 years follow-up. Subjects who reported difficulty with balance before 1990 (baseline) were 1.8 more times likely to develop PD, relative to those who reported no balance difficulty (pooled multivariate RR=1.8; 95%CI: 1.3, 2.5; P<0.0001). When we further examined associations between perceived imbalance at baseline and PD onset during different time periods, we found a significant elevation of PD risk only during the first 4 years of follow-up. This result suggests that the imbalance may in some cases be an early sign of PD, and may represent the onset of motor symptoms although they have not been clinically recognized.
Url:
DOI: 10.1002/mds.21919
PubMed: 18181208
PubMed Central: 2385782
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PMC:2385782Le document en format XML
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<author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
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<author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael A." last="Schwarzschild">Michael A. Schwarzschild</name>
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<author><name sortKey="Logroscino, Giancarlo" sort="Logroscino, Giancarlo" uniqKey="Logroscino G" first="Giancarlo" last="Logroscino">Giancarlo Logroscino</name>
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<term>Attitude to Health</term>
<term>Awareness</term>
<term>Diagnosis, Differential</term>
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<term>Follow-Up Studies</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">We prospectively examined associations between perceived imbalance and Parkinson’s disease (PD) risk in the Health Professional Follow-up Study (HPFS), and Nurses’ Health Study (NHS). We included 39,087 men and 82,299 women free of PD at baseline (1990) in the current analyses. We documented 449 incident PD cases during 12 years follow-up. Subjects who reported difficulty with balance before 1990 (baseline) were 1.8 more times likely to develop PD, relative to those who reported no balance difficulty (pooled multivariate RR=1.8; 95%CI: 1.3, 2.5; P<0.0001). When we further examined associations between perceived imbalance at baseline and PD onset during different time periods, we found a significant elevation of PD risk only during the first 4 years of follow-up. This result suggests that the imbalance may in some cases be an early sign of PD, and may represent the onset of motor symptoms although they have not been clinically recognized.</p>
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