Bilateral pedunculopontine nuclei strokes presenting as freezing of gait.
Identifieur interne : 002022 ( Ncbi/Curation ); précédent : 002021; suivant : 002023Bilateral pedunculopontine nuclei strokes presenting as freezing of gait.
Auteurs : Sheng-Han Kuo [États-Unis] ; Christopher Kenney ; Joseph Jankovic [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Freezing Reaction, Cataleptic (physiology), Functional Laterality (physiology), Gait (physiology), Humans, Locomotion (physiology), Magnetic Resonance Imaging, Male, Neuropsychological Tests, Parkinson Disease (diagnosis), Parkinson Disease (etiology), Parkinson Disease (physiopathology), Pedunculopontine Tegmental Nucleus (blood supply), Pedunculopontine Tegmental Nucleus (pathology), Pedunculopontine Tegmental Nucleus (physiopathology), Stroke (complications), Stroke (pathology), Stroke (physiopathology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (etiology), Supranuclear Palsy, Progressive (physiopathology), Videotape Recording.
- MESH :
- blood supply : Pedunculopontine Tegmental Nucleus.
- complications : Stroke.
- diagnosis : Cognition Disorders, Parkinson Disease, Supranuclear Palsy, Progressive.
- etiology : Cognition Disorders, Parkinson Disease, Supranuclear Palsy, Progressive.
- pathology : Pedunculopontine Tegmental Nucleus, Stroke.
- physiology : Freezing Reaction, Cataleptic, Functional Laterality, Gait, Locomotion.
- physiopathology : Parkinson Disease, Pedunculopontine Tegmental Nucleus, Stroke, Supranuclear Palsy, Progressive.
- Aged, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Videotape Recording.
Abstract
The penduculopontine nucleus (PPN) has been suggested to play an important role in locomotion, based on animal studies, but its function in humans has not been well defined. Autopsy studies have suggested that PPN pathology correlates with gait dysfunction in Parkinson's disease and in progressive supranuclear palsy but direct clinical evidence is lacking. We report a patient with bilateral PPN infarcts whose dominant clinical feature was freezing of gait, thus providing evidence that PPN is involved in human locomotion and that damage to the PPN may lead to abnormal gait.
DOI: 10.1002/mds.21917
PubMed: 18181207
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pubmed:18181207Le document en format XML
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<author><name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas 77030</wicri:regionArea>
<wicri:noRegion>Texas 77030</wicri:noRegion>
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<author><name sortKey="Kenney, Christopher" sort="Kenney, Christopher" uniqKey="Kenney C" first="Christopher" last="Kenney">Christopher Kenney</name>
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Bilateral pedunculopontine nuclei strokes presenting as freezing of gait.</title>
<author><name sortKey="Kuo, Sheng Han" sort="Kuo, Sheng Han" uniqKey="Kuo S" first="Sheng-Han" last="Kuo">Sheng-Han Kuo</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, Texas 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Kenney, Christopher" sort="Kenney, Christopher" uniqKey="Kenney C" first="Christopher" last="Kenney">Christopher Kenney</name>
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
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<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (etiology)</term>
<term>Freezing Reaction, Cataleptic (physiology)</term>
<term>Functional Laterality (physiology)</term>
<term>Gait (physiology)</term>
<term>Humans</term>
<term>Locomotion (physiology)</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Pedunculopontine Tegmental Nucleus (blood supply)</term>
<term>Pedunculopontine Tegmental Nucleus (pathology)</term>
<term>Pedunculopontine Tegmental Nucleus (physiopathology)</term>
<term>Stroke (complications)</term>
<term>Stroke (pathology)</term>
<term>Stroke (physiopathology)</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>Supranuclear Palsy, Progressive (etiology)</term>
<term>Supranuclear Palsy, Progressive (physiopathology)</term>
<term>Videotape Recording</term>
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</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pedunculopontine Tegmental Nucleus</term>
<term>Stroke</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Freezing Reaction, Cataleptic</term>
<term>Functional Laterality</term>
<term>Gait</term>
<term>Locomotion</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
<term>Pedunculopontine Tegmental Nucleus</term>
<term>Stroke</term>
<term>Supranuclear Palsy, Progressive</term>
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<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Neuropsychological Tests</term>
<term>Videotape Recording</term>
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<front><div type="abstract" xml:lang="en">The penduculopontine nucleus (PPN) has been suggested to play an important role in locomotion, based on animal studies, but its function in humans has not been well defined. Autopsy studies have suggested that PPN pathology correlates with gait dysfunction in Parkinson's disease and in progressive supranuclear palsy but direct clinical evidence is lacking. We report a patient with bilateral PPN infarcts whose dominant clinical feature was freezing of gait, thus providing evidence that PPN is involved in human locomotion and that damage to the PPN may lead to abnormal gait.</div>
</front>
</TEI>
</record>
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