Impact of pramipexole on the onset of levodopa-related dyskinesias.
Identifieur interne : 001C64 ( Ncbi/Curation ); précédent : 001C63; suivant : 001C65Impact of pramipexole on the onset of levodopa-related dyskinesias.
Auteurs : Radu Constantinescu [États-Unis] ; Megan Romer ; Michael P. Mcdermott ; Cornelia Kamp ; Karl KieburtzSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Benzothiazoles, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Akathisia, Drug-Induced.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Probability.
Abstract
Dyskinesias are a major complication of dopaminergic therapy in the long-term treatment of Parkinson's disease. In the CALM-PD trial, subjects were initially randomized to levodopa or pramipexole and could later add levodopa if needed. After adjusting for disease duration and daily levodopa dosage, the incidence of dyskinesias after initiating levodopa was not significantly different among subjects initially randomized to levodopa and those initially randomized to pramipexole.
DOI: 10.1002/mds.21292
PubMed: 17534955
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Mcdermott</name></author><author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name></author><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21292</idno><idno type="RBID">pubmed:17534955</idno><idno type="pmid">17534955</idno><idno type="wicri:Area/PubMed/Corpus">002675</idno><idno type="wicri:Area/PubMed/Curation">002675</idno><idno type="wicri:Area/PubMed/Checkpoint">002778</idno><idno type="wicri:Area/Ncbi/Merge">001C64</idno><idno type="wicri:Area/Ncbi/Curation">001C64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of pramipexole on the onset of levodopa-related dyskinesias.</title><author><name sortKey="Constantinescu, Radu" sort="Constantinescu, Radu" uniqKey="Constantinescu R" first="Radu" last="Constantinescu">Radu Constantinescu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA. radu.constantinescu@vgregion.se</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Romer, Megan" sort="Romer, Megan" uniqKey="Romer M" first="Megan" last="Romer">Megan Romer</name></author><author><name sortKey="Mcdermott, Michael P" sort="Mcdermott, Michael P" uniqKey="Mcdermott M" first="Michael P" last="Mcdermott">Michael P. Mcdermott</name></author><author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name></author><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Akathisia, Drug-Induced (etiology)</term><term>Antiparkinson Agents (adverse effects)</term><term>Benzothiazoles (adverse effects)</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Probability</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Benzothiazoles</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Akathisia, Drug-Induced</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Probability</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dyskinesias are a major complication of dopaminergic therapy in the long-term treatment of Parkinson's disease. In the CALM-PD trial, subjects were initially randomized to levodopa or pramipexole and could later add levodopa if needed. After adjusting for disease duration and daily levodopa dosage, the incidence of dyskinesias after initiating levodopa was not significantly different among subjects initially randomized to levodopa and those initially randomized to pramipexole.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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