Impact of pramipexole on the onset of levodopa-related dyskinesias.
Identifieur interne : 002675 ( PubMed/Curation ); précédent : 002674; suivant : 002676Impact of pramipexole on the onset of levodopa-related dyskinesias.
Auteurs : Radu Constantinescu [États-Unis] ; Megan Romer ; Michael P. Mcdermott ; Cornelia Kamp ; Karl KieburtzSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Benzothiazoles, Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Akathisia, Drug-Induced.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Probability.
Abstract
Dyskinesias are a major complication of dopaminergic therapy in the long-term treatment of Parkinson's disease. In the CALM-PD trial, subjects were initially randomized to levodopa or pramipexole and could later add levodopa if needed. After adjusting for disease duration and daily levodopa dosage, the incidence of dyskinesias after initiating levodopa was not significantly different among subjects initially randomized to levodopa and those initially randomized to pramipexole.
DOI: 10.1002/mds.21292
PubMed: 17534955
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pubmed:17534955Le document en format XML
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<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA. radu.constantinescu@vgregion.se</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Mcdermott, Michael P" sort="Mcdermott, Michael P" uniqKey="Mcdermott M" first="Michael P" last="Mcdermott">Michael P. Mcdermott</name>
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<author><name sortKey="Kamp, Cornelia" sort="Kamp, Cornelia" uniqKey="Kamp C" first="Cornelia" last="Kamp">Cornelia Kamp</name>
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<author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name>
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<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
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<front><div type="abstract" xml:lang="en">Dyskinesias are a major complication of dopaminergic therapy in the long-term treatment of Parkinson's disease. In the CALM-PD trial, subjects were initially randomized to levodopa or pramipexole and could later add levodopa if needed. After adjusting for disease duration and daily levodopa dosage, the incidence of dyskinesias after initiating levodopa was not significantly different among subjects initially randomized to levodopa and those initially randomized to pramipexole.</div>
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<Abstract><AbstractText>Dyskinesias are a major complication of dopaminergic therapy in the long-term treatment of Parkinson's disease. In the CALM-PD trial, subjects were initially randomized to levodopa or pramipexole and could later add levodopa if needed. After adjusting for disease duration and daily levodopa dosage, the incidence of dyskinesias after initiating levodopa was not significantly different among subjects initially randomized to levodopa and those initially randomized to pramipexole.</AbstractText>
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