Movement Disorders (revue)

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Age at menopause predicts age at onset of Parkinson's disease.

Identifieur interne : 001883 ( Ncbi/Curation ); précédent : 001882; suivant : 001884

Age at menopause predicts age at onset of Parkinson's disease.

Auteurs : Paolo Ragonese [Italie] ; Marco D'Amelio ; Graziella Callari ; Giuseppe Salemi ; Letterio Morgante ; Giovanni Savettieri

Source :

RBID : pubmed:17029261

English descriptors

Abstract

We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.

DOI: 10.1002/mds.21127
PubMed: 17029261

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<nlm:affiliation>Dipartimento di Neuroscienze Cliniche, University of Palermo, Palermo, Italy.</nlm:affiliation>
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<term>Aging (physiology)</term>
<term>Female</term>
<term>Humans</term>
<term>Linear Models</term>
<term>Menopause (physiology)</term>
<term>Middle Aged</term>
<term>Parkinson Disease</term>
<term>Pregnancy</term>
<term>Risk Assessment</term>
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<term>Aging</term>
<term>Menopause</term>
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<term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
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<term>Female</term>
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<term>Linear Models</term>
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<div type="abstract" xml:lang="en">We investigated the association between age at onset of Parkinson's disease (PD) and fertile life characteristics in 145 women. Linear regression analyses showed a significant correlation between age at PD onset and age at menopause (P = 0.003), between age at PD onset and fertile life duration (P = 0.008), and a nonsignificant correlation between PD onset and cumulative duration of pregnancies (P = 0.23). These results support the possible role of estrogens in PD.</div>
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