Increase in body weight after pramipexole treatment in Parkinson's disease.
Identifieur interne : 001843 ( Ncbi/Curation ); précédent : 001842; suivant : 001844Increase in body weight after pramipexole treatment in Parkinson's disease.
Auteurs : Hatice Kumru [Espagne] ; Joan Santamaria ; Francesc Valldeoriola ; Maria J. Marti ; Eduardo TolosaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Affect (drug effects), Aged, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Benzothiazoles (pharmacology), Benzothiazoles (therapeutic use), Body Mass Index, Body Weight (drug effects), Female, Follow-Up Studies, Humans, Male, Middle Aged, Movement (drug effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Severity of Illness Index.
- MESH :
- chemical , pharmacology : Antiparkinson Agents, Benzothiazoles.
- drug effects : Affect, Body Weight, Movement.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Antiparkinson Agents, Benzothiazoles.
- Aged, Body Mass Index, Female, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS-III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D(3) receptors involved in the control of feeding may be responsible for weight gain in PD.
DOI: 10.1002/mds.21086
PubMed: 16972276
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pubmed:16972276Le document en format XML
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Marti</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.21086</idno><idno type="RBID">pubmed:16972276</idno><idno type="pmid">16972276</idno><idno type="wicri:Area/PubMed/Corpus">002A96</idno><idno type="wicri:Area/PubMed/Curation">002A96</idno><idno type="wicri:Area/PubMed/Checkpoint">002C72</idno><idno type="wicri:Area/Ncbi/Merge">001843</idno><idno type="wicri:Area/Ncbi/Curation">001843</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Increase in body weight after pramipexole treatment in Parkinson's disease.</title><author><name sortKey="Kumru, Hatice" sort="Kumru, Hatice" uniqKey="Kumru H" first="Hatice" last="Kumru">Hatice Kumru</name><affiliation wicri:level="3"><nlm:affiliation>Neurology Service, Hospital Clínic de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer , Universitat de Barcelona, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurology Service, Hospital Clínic de Barcelona and Institut d'Investigacions Biomèdiques August Pi i Sunyer , Universitat de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Santamaria, Joan" sort="Santamaria, Joan" uniqKey="Santamaria J" first="Joan" last="Santamaria">Joan Santamaria</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Marti, Maria J" sort="Marti, Maria J" uniqKey="Marti M" first="Maria J" last="Marti">Maria J. Marti</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Affect (drug effects)</term><term>Aged</term><term>Antiparkinson Agents (pharmacology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Benzothiazoles (pharmacology)</term><term>Benzothiazoles (therapeutic use)</term><term>Body Mass Index</term><term>Body Weight (drug effects)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement (drug effects)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiparkinson Agents</term><term>Benzothiazoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Affect</term><term>Body Weight</term><term>Movement</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Benzothiazoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Body Mass Index</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Body weight changes occur during the clinical course of Parkinson's disease (PD) and with surgical treatment, but the effect of dopaminergic treatment on weight is unknown. Body mass index (BMI), Hamilton depression scale score (HDS), and Unified Parkinson's Disease Rating Scale III (UPRS-III) were measured before and 3 months after starting pramipexole in 28 PD patients. Pramipexole produced a significant weight increase, as well as motor and mood improvement (P <0.001). HDS and BMI changes were mildly related (P = 0.05). A direct effect of pramipexole on limbic D(3) receptors involved in the control of feeding may be responsible for weight gain in PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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