Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease.
Identifieur interne : 001740 ( Ncbi/Curation ); précédent : 001739; suivant : 001741Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease.
Auteurs : Michela Barichella [Italie] ; Agnieszka Marczewska ; Roberta De Notaris ; Antonella Vairo ; Cinzia Baldo ; Andrea Mauri ; Chiara Savardi ; Gianni PezzoliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Combined Modality Therapy, Cross-Over Studies, Diet, Protein-Restricted (adverse effects), Drug Therapy, Combination, Female, Food-Drug Interactions, Humans, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Middle Aged, Neurologic Examination, Parkinson Disease (diet therapy), Parkinson Disease (physiopathology), Patient Satisfaction, Pilot Projects, Postprandial Period (physiology), Single-Blind Method.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Levodopa.
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- adverse effects : Diet, Protein-Restricted.
- diet therapy : Parkinson Disease.
- physiology : Postprandial Period.
- physiopathology : Parkinson Disease.
- Aged, Combined Modality Therapy, Cross-Over Studies, Drug Therapy, Combination, Female, Food-Drug Interactions, Humans, Male, Middle Aged, Neurologic Examination, Patient Satisfaction, Pilot Projects, Single-Blind Method.
Abstract
Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low-protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross-over, single-blind, pilot clinical trial comparing a 2-month balanced diet with a 2-month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 +/- 73 min vs. 79 +/- 72 min and total off, 164 +/- 148 min vs. 271 +/- 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 +/- 2.7 hr vs. 4.7 +/- 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, -1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed.
DOI: 10.1002/mds.21003
PubMed: 16773618
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<front><div type="abstract" xml:lang="en">Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low-protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross-over, single-blind, pilot clinical trial comparing a 2-month balanced diet with a 2-month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 +/- 73 min vs. 79 +/- 72 min and total off, 164 +/- 148 min vs. 271 +/- 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 +/- 2.7 hr vs. 4.7 +/- 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, -1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed.</div>
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