Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study.
Identifieur interne : 001739 ( Ncbi/Curation ); précédent : 001738; suivant : 001740Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study.
Auteurs : Isaac Shpirer [Israël] ; Ala Miniovitz ; Colin Klein ; Richard Goldstein ; Tatiana Prokhorov ; Jack Theitler ; Lea Pollak ; Jose Martin RabeySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Benzodiazepines (therapeutic use), Clonazepam (therapeutic use), Cohort Studies, Comorbidity, Disorders of Excessive Somnolence (diagnosis), Disorders of Excessive Somnolence (drug therapy), Disorders of Excessive Somnolence (epidemiology), Dopamine Agonists (therapeutic use), Drug Therapy, Combination, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Polysomnography, Reference Values, Restless Legs Syndrome (diagnosis), Restless Legs Syndrome (drug therapy), Restless Legs Syndrome (epidemiology), Sleep Stages (drug effects), Wakefulness (drug effects).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Benzodiazepines, Clonazepam, Dopamine Agonists, Levodopa.
- diagnosis : Disorders of Excessive Somnolence, Parkinson Disease, Restless Legs Syndrome.
- drug effects : Sleep Stages, Wakefulness.
- drug therapy : Disorders of Excessive Somnolence, Parkinson Disease, Restless Legs Syndrome.
- epidemiology : Disorders of Excessive Somnolence, Parkinson Disease, Restless Legs Syndrome.
- Aged, Aged, 80 and over, Cohort Studies, Comorbidity, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Polysomnography, Reference Values.
Abstract
To investigate excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD), the reasons for which have not yet been clarified, polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT) were performed in 46 patients with PD, and, in addition, PSG was performed in 30 healthy controls. Assessment included Epworth Sleepiness Score (ESS), Mini-Mental State Examination (MMSE), and Hamilton Test (HT) for depression. Fifty percent of PD patients reported EDS (ESS, 10 +/- 4.5 vs. 6.9 +/- 3.7; P = 0.01). Compared with controls, PD patients as a group had lower sleep efficiency (65 +/- 22 vs. 77 +/- 14; P = 0.03), a longer Stage 2 (73 +/- 12 vs. 67 +/- 12; P = 0.03), and a shorter rapid eye movement stage (8 +/- 8 vs. 17 +/- 8; P < 0.001). Clinical data and sleep characteristics were similar in PD with/without EDS. Of interest, patients treated with clonazepam (CLNZ) had lower EDS than those without CLNZ (ESS, 7.9 +/- 4.7 vs. 11.3 +/- 4.0; P = 0.03). These patients suffered less periodic leg movement during sleep (2.1 +/- 2.7 vs. 12.4 +/- 28; P = 0.04), which might explain the finding. No correlation was found between ESS, MSLT, and all other clinical features analyzed. In PD patients, according to the data obtained, severity of EDS does not depend on any specific clinical factor and the etiology is probably multifactorial. Paradoxically, PD patients treated with CLNZ were less sleepy than patients not treated with CLNZ.
DOI: 10.1002/mds.21002
PubMed: 16773617
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study.</title><author><name sortKey="Shpirer, Isaac" sort="Shpirer, Isaac" uniqKey="Shpirer I" first="Isaac" last="Shpirer">Isaac Shpirer</name><affiliation wicri:level="1"><nlm:affiliation>Sleep Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel, affiliated to Sackler School of Medicine, Tel Aviv University, Israel. i_shpirer@yahoo.com</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Sleep Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel, affiliated to Sackler School of Medicine, Tel Aviv University</wicri:regionArea><wicri:noRegion>Tel Aviv University</wicri:noRegion></affiliation></author><author><name sortKey="Miniovitz, Ala" sort="Miniovitz, Ala" uniqKey="Miniovitz A" first="Ala" last="Miniovitz">Ala Miniovitz</name></author><author><name sortKey="Klein, Colin" sort="Klein, Colin" uniqKey="Klein C" first="Colin" last="Klein">Colin Klein</name></author><author><name sortKey="Goldstein, Richard" sort="Goldstein, Richard" uniqKey="Goldstein R" first="Richard" last="Goldstein">Richard Goldstein</name></author><author><name sortKey="Prokhorov, Tatiana" sort="Prokhorov, Tatiana" uniqKey="Prokhorov T" first="Tatiana" last="Prokhorov">Tatiana Prokhorov</name></author><author><name sortKey="Theitler, Jack" sort="Theitler, Jack" uniqKey="Theitler J" first="Jack" last="Theitler">Jack Theitler</name></author><author><name sortKey="Pollak, Lea" sort="Pollak, Lea" uniqKey="Pollak L" first="Lea" last="Pollak">Lea Pollak</name></author><author><name sortKey="Rabey, Jose Martin" sort="Rabey, Jose Martin" uniqKey="Rabey J" first="Jose Martin" last="Rabey">Jose Martin Rabey</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.21002</idno><idno type="RBID">pubmed:16773617</idno><idno type="pmid">16773617</idno><idno type="wicri:Area/PubMed/Corpus">002B97</idno><idno type="wicri:Area/PubMed/Curation">002B97</idno><idno type="wicri:Area/PubMed/Checkpoint">002D30</idno><idno type="wicri:Area/Ncbi/Merge">001739</idno><idno type="wicri:Area/Ncbi/Curation">001739</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Excessive daytime sleepiness in patients with Parkinson's disease: a polysomnography study.</title><author><name sortKey="Shpirer, Isaac" sort="Shpirer, Isaac" uniqKey="Shpirer I" first="Isaac" last="Shpirer">Isaac Shpirer</name><affiliation wicri:level="1"><nlm:affiliation>Sleep Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel, affiliated to Sackler School of Medicine, Tel Aviv University, Israel. i_shpirer@yahoo.com</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Sleep Laboratory, Assaf Harofeh Medical Center, Zerifin, Israel, affiliated to Sackler School of Medicine, Tel Aviv University</wicri:regionArea><wicri:noRegion>Tel Aviv University</wicri:noRegion></affiliation></author><author><name sortKey="Miniovitz, Ala" sort="Miniovitz, Ala" uniqKey="Miniovitz A" first="Ala" last="Miniovitz">Ala Miniovitz</name></author><author><name sortKey="Klein, Colin" sort="Klein, Colin" uniqKey="Klein C" first="Colin" last="Klein">Colin Klein</name></author><author><name sortKey="Goldstein, Richard" sort="Goldstein, Richard" uniqKey="Goldstein R" first="Richard" last="Goldstein">Richard Goldstein</name></author><author><name sortKey="Prokhorov, Tatiana" sort="Prokhorov, Tatiana" uniqKey="Prokhorov T" first="Tatiana" last="Prokhorov">Tatiana Prokhorov</name></author><author><name sortKey="Theitler, Jack" sort="Theitler, Jack" uniqKey="Theitler J" first="Jack" last="Theitler">Jack Theitler</name></author><author><name sortKey="Pollak, Lea" sort="Pollak, Lea" uniqKey="Pollak L" first="Lea" last="Pollak">Lea Pollak</name></author><author><name sortKey="Rabey, Jose Martin" sort="Rabey, Jose Martin" uniqKey="Rabey J" first="Jose Martin" last="Rabey">Jose Martin Rabey</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (therapeutic use)</term><term>Benzodiazepines (therapeutic use)</term><term>Clonazepam (therapeutic use)</term><term>Cohort Studies</term><term>Comorbidity</term><term>Disorders of Excessive Somnolence (diagnosis)</term><term>Disorders of Excessive Somnolence (drug therapy)</term><term>Disorders of Excessive Somnolence (epidemiology)</term><term>Dopamine Agonists (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Polysomnography</term><term>Reference Values</term><term>Restless Legs Syndrome (diagnosis)</term><term>Restless Legs Syndrome (drug therapy)</term><term>Restless Legs Syndrome (epidemiology)</term><term>Sleep Stages (drug effects)</term><term>Wakefulness (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Benzodiazepines</term><term>Clonazepam</term><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Sleep Stages</term><term>Wakefulness</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Disorders of Excessive Somnolence</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Comorbidity</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polysomnography</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD), the reasons for which have not yet been clarified, polysomnography (PSG) and the Multiple Sleep Latency Test (MSLT) were performed in 46 patients with PD, and, in addition, PSG was performed in 30 healthy controls. Assessment included Epworth Sleepiness Score (ESS), Mini-Mental State Examination (MMSE), and Hamilton Test (HT) for depression. Fifty percent of PD patients reported EDS (ESS, 10 +/- 4.5 vs. 6.9 +/- 3.7; P = 0.01). Compared with controls, PD patients as a group had lower sleep efficiency (65 +/- 22 vs. 77 +/- 14; P = 0.03), a longer Stage 2 (73 +/- 12 vs. 67 +/- 12; P = 0.03), and a shorter rapid eye movement stage (8 +/- 8 vs. 17 +/- 8; P < 0.001). Clinical data and sleep characteristics were similar in PD with/without EDS. Of interest, patients treated with clonazepam (CLNZ) had lower EDS than those without CLNZ (ESS, 7.9 +/- 4.7 vs. 11.3 +/- 4.0; P = 0.03). These patients suffered less periodic leg movement during sleep (2.1 +/- 2.7 vs. 12.4 +/- 28; P = 0.04), which might explain the finding. No correlation was found between ESS, MSLT, and all other clinical features analyzed. In PD patients, according to the data obtained, severity of EDS does not depend on any specific clinical factor and the etiology is probably multifactorial. Paradoxically, PD patients treated with CLNZ were less sleepy than patients not treated with CLNZ.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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