End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation.
Identifieur interne : 001655 ( Ncbi/Curation ); précédent : 001654; suivant : 001656End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation.
Auteurs : Diana Apetauerova [États-Unis] ; R Kevin Ryan ; Susie I. Ro ; Jeffrey Arle ; Jay Shils ; Efstathios Papavassiliou ; Daniel TarsySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- etiology : Dyskinesias.
- therapy : Dyskinesias, Parkinson Disease.
- Deep Brain Stimulation, Female, Functional Laterality, Globus Pallidus, Humans, Middle Aged, Subthalamic Nucleus.
Abstract
We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was wearing off. Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia.
DOI: 10.1002/mds.20896
PubMed: 16637040
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pubmed:16637040Le document en format XML
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts</wicri:regionArea>
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<author><name sortKey="Ro, Susie I" sort="Ro, Susie I" uniqKey="Ro S" first="Susie I" last="Ro">Susie I. Ro</name>
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<author><name sortKey="Shils, Jay" sort="Shils, Jay" uniqKey="Shils J" first="Jay" last="Shils">Jay Shils</name>
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<author><name sortKey="Papavassiliou, Efstathios" sort="Papavassiliou, Efstathios" uniqKey="Papavassiliou E" first="Efstathios" last="Papavassiliou">Efstathios Papavassiliou</name>
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<front><div type="abstract" xml:lang="en">We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was wearing off. Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia.</div>
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