Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life.
Identifieur interne : 001654 ( Ncbi/Curation ); précédent : 001653; suivant : 001655Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life.
Auteurs : Angelo Antonini [Italie] ; Silvana Tesei ; Anna Zecchinelli ; Paolo Barone ; Danilo De Gaspari ; Margherita Canesi ; Giorgio Sacilotto ; Nicoletta Meucci ; Claudio Mariani ; Gianni PezzoliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Amitriptyline (therapeutic use), Antidepressive Agents (therapeutic use), Depression (etiology), Depression (prevention & control), Female, Humans, Male, Middle Aged, Parkinson Disease (psychology), Quality of Life, Serotonin Uptake Inhibitors (therapeutic use), Sertraline (therapeutic use), Single-Blind Method.
- MESH :
- chemical , therapeutic use : Amitriptyline, Antidepressive Agents, Serotonin Uptake Inhibitors, Sertraline.
- etiology : Depression.
- prevention & control : Depression.
- psychology : Parkinson Disease.
- Female, Humans, Male, Middle Aged, Quality of Life, Single-Blind Method.
Abstract
We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study. Both drugs significantly reduced the Hamilton Depression Rating Scale (HDRS-17) score. Completion rate was 75% for sertraline (12 of 16) and 73% for amitriptyline (11 of 15). Responder rate (HDRS-17 score reduction >/= 50%) was 83.3% for sertraline and 72.7% for amitriptyline. Sertraline but not amitriptyline treatment determined a significant benefit on quality of life (PDQ-39 scale). We found no change in Unified Parkinson's Disease Rating Scale scores. However, the improvement in specific PDQ-39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self-perception of motor function and further emphasizes the need for its treatment.
DOI: 10.1002/mds.20895
PubMed: 16637039
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pubmed:16637039Le document en format XML
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<term>Parkinson Disease (psychology)</term>
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<front><div type="abstract" xml:lang="en">We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study. Both drugs significantly reduced the Hamilton Depression Rating Scale (HDRS-17) score. Completion rate was 75% for sertraline (12 of 16) and 73% for amitriptyline (11 of 15). Responder rate (HDRS-17 score reduction >/= 50%) was 83.3% for sertraline and 72.7% for amitriptyline. Sertraline but not amitriptyline treatment determined a significant benefit on quality of life (PDQ-39 scale). We found no change in Unified Parkinson's Disease Rating Scale scores. However, the improvement in specific PDQ-39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self-perception of motor function and further emphasizes the need for its treatment.</div>
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