Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?
Identifieur interne : 001606 ( Ncbi/Curation ); précédent : 001605; suivant : 001607Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?
Auteurs : Stefanie Klaffke [Royaume-Uni] ; Inke R. König ; Fritz Poustka ; Andreas Ziegler ; Johannes Hebebrand ; Oliver BandmannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adolescent, Amino Acid Substitution, Brain-Derived Neurotrophic Factor (genetics), Child, DNA (blood), DNA (isolation & purification), European Continental Ancestry Group (genetics), Humans, Linkage Disequilibrium, Methionine, Obsessive-Compulsive Disorder (genetics), Polymorphism, Single Nucleotide, Risk Factors, Tourette Syndrome (genetics), Valine.
- MESH :
- chemical , blood : DNA.
- chemical , genetics : Brain-Derived Neurotrophic Factor.
- chemical , isolation & purification : DNA.
- genetics : European Continental Ancestry Group, Obsessive-Compulsive Disorder, Tourette Syndrome.
- Adolescent, Amino Acid Substitution, Child, Humans, Linkage Disequilibrium, Methionine, Polymorphism, Single Nucleotide, Risk Factors, Valine.
Abstract
A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported. Patients with Gilles de la Tourette's syndrome (GTS) often develop OCD as well, suggesting a shared genetic susceptibility for OCD and GTS. We investigated whether BNDF is associated not only with OCD but also with GTS. The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios. The extended transmission/disequilibrium test was applied. The transmission rates for both alleles did not differ from the expected transmission rates. This finding suggests that GTS and OCD may have distinct genetic risk factors.
DOI: 10.1002/mds.20849
PubMed: 16541456
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<author><name sortKey="Klaffke, Stefanie" sort="Klaffke, Stefanie" uniqKey="Klaffke S" first="Stefanie" last="Klaffke">Stefanie Klaffke</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<wicri:noRegion>University of Sheffield</wicri:noRegion>
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<author><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R" last="König">Inke R. König</name>
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<author><name sortKey="Poustka, Fritz" sort="Poustka, Fritz" uniqKey="Poustka F" first="Fritz" last="Poustka">Fritz Poustka</name>
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<author><name sortKey="Ziegler, Andreas" sort="Ziegler, Andreas" uniqKey="Ziegler A" first="Andreas" last="Ziegler">Andreas Ziegler</name>
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<author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name>
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<author><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?</title>
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<author><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R" last="König">Inke R. König</name>
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<author><name sortKey="Poustka, Fritz" sort="Poustka, Fritz" uniqKey="Poustka F" first="Fritz" last="Poustka">Fritz Poustka</name>
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<author><name sortKey="Ziegler, Andreas" sort="Ziegler, Andreas" uniqKey="Ziegler A" first="Andreas" last="Ziegler">Andreas Ziegler</name>
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<author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Child</term>
<term>DNA (blood)</term>
<term>DNA (isolation & purification)</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Methionine</term>
<term>Obsessive-Compulsive Disorder (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk Factors</term>
<term>Tourette Syndrome (genetics)</term>
<term>Valine</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term>
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<term>Linkage Disequilibrium</term>
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<front><div type="abstract" xml:lang="en">A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported. Patients with Gilles de la Tourette's syndrome (GTS) often develop OCD as well, suggesting a shared genetic susceptibility for OCD and GTS. We investigated whether BNDF is associated not only with OCD but also with GTS. The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios. The extended transmission/disequilibrium test was applied. The transmission rates for both alleles did not differ from the expected transmission rates. This finding suggests that GTS and OCD may have distinct genetic risk factors.</div>
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