Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?
Identifieur interne : 002E43 ( PubMed/Checkpoint ); précédent : 002E42; suivant : 002E44Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?
Auteurs : Stefanie Klaffke [Royaume-Uni] ; Inke R. König ; Fritz Poustka ; Andreas Ziegler ; Johannes Hebebrand ; Oliver BandmannSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Adolescent, Amino Acid Substitution, Brain-Derived Neurotrophic Factor (genetics), Child, DNA (blood), DNA (isolation & purification), European Continental Ancestry Group (genetics), Humans, Linkage Disequilibrium, Methionine, Obsessive-Compulsive Disorder (genetics), Polymorphism, Single Nucleotide, Risk Factors, Tourette Syndrome (genetics), Valine.
- MESH :
- chemical , blood : DNA.
- chemical , genetics : Brain-Derived Neurotrophic Factor.
- chemical , isolation & purification : DNA.
- genetics : European Continental Ancestry Group, Obsessive-Compulsive Disorder, Tourette Syndrome.
- Adolescent, Amino Acid Substitution, Child, Humans, Linkage Disequilibrium, Methionine, Polymorphism, Single Nucleotide, Risk Factors, Valine.
Abstract
A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported. Patients with Gilles de la Tourette's syndrome (GTS) often develop OCD as well, suggesting a shared genetic susceptibility for OCD and GTS. We investigated whether BNDF is associated not only with OCD but also with GTS. The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios. The extended transmission/disequilibrium test was applied. The transmission rates for both alleles did not differ from the expected transmission rates. This finding suggests that GTS and OCD may have distinct genetic risk factors.
DOI: 10.1002/mds.20849
PubMed: 16541456
Affiliations:
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König</name></author><author><name sortKey="Poustka, Fritz" sort="Poustka, Fritz" uniqKey="Poustka F" first="Fritz" last="Poustka">Fritz Poustka</name></author><author><name sortKey="Ziegler, Andreas" sort="Ziegler, Andreas" uniqKey="Ziegler A" first="Andreas" last="Ziegler">Andreas Ziegler</name></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name></author><author><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="doi">10.1002/mds.20849</idno><idno type="RBID">pubmed:16541456</idno><idno type="pmid">16541456</idno><idno type="wicri:Area/PubMed/Corpus">002D25</idno><idno type="wicri:Area/PubMed/Curation">002D25</idno><idno type="wicri:Area/PubMed/Checkpoint">002E43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?</title><author><name sortKey="Klaffke, Stefanie" sort="Klaffke, Stefanie" uniqKey="Klaffke S" first="Stefanie" last="Klaffke">Stefanie Klaffke</name><affiliation wicri:level="1"><nlm:affiliation>Academic Neurology Unit, Division of Genomic Medicine, University of Sheffield, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Academic Neurology Unit, Division of Genomic Medicine, University of Sheffield</wicri:regionArea><wicri:noRegion>University of Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R" last="König">Inke R. König</name></author><author><name sortKey="Poustka, Fritz" sort="Poustka, Fritz" uniqKey="Poustka F" first="Fritz" last="Poustka">Fritz Poustka</name></author><author><name sortKey="Ziegler, Andreas" sort="Ziegler, Andreas" uniqKey="Ziegler A" first="Andreas" last="Ziegler">Andreas Ziegler</name></author><author><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name></author><author><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Amino Acid Substitution</term><term>Brain-Derived Neurotrophic Factor (genetics)</term><term>Child</term><term>DNA (blood)</term><term>DNA (isolation & purification)</term><term>European Continental Ancestry Group (genetics)</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Methionine</term><term>Obsessive-Compulsive Disorder (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Tourette Syndrome (genetics)</term><term>Valine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>DNA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>DNA</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term><term>Obsessive-Compulsive Disorder</term><term>Tourette Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Amino Acid Substitution</term><term>Child</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Methionine</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Valine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported. Patients with Gilles de la Tourette's syndrome (GTS) often develop OCD as well, suggesting a shared genetic susceptibility for OCD and GTS. We investigated whether BNDF is associated not only with OCD but also with GTS. The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios. The extended transmission/disequilibrium test was applied. The transmission rates for both alleles did not differ from the expected transmission rates. This finding suggests that GTS and OCD may have distinct genetic risk factors.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16541456</PMID><DateCreated><Year>2006</Year><Month>06</Month><Day>13</Day></DateCreated><DateCompleted><Year>2006</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>6</Issue><PubDate><Year>2006</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Brain-derived neurotrophic factor: a genetic risk factor for obsessive-compulsive disorder and Tourette syndrome?</ArticleTitle><Pagination><MedlinePgn>881-3</MedlinePgn></Pagination><Abstract><AbstractText>A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported. Patients with Gilles de la Tourette's syndrome (GTS) often develop OCD as well, suggesting a shared genetic susceptibility for OCD and GTS. We investigated whether BNDF is associated not only with OCD but also with GTS. The G196A polymorphism of the BNDF gene was genotyped in 88 GTS trios. The extended transmission/disequilibrium test was applied. The transmission rates for both alleles did not differ from the expected transmission rates. This finding suggests that GTS and OCD may have distinct genetic risk factors.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Klaffke</LastName><ForeName>Stefanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Academic Neurology Unit, Division of Genomic Medicine, University of Sheffield, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>König</LastName><ForeName>Inke R</ForeName><Initials>IR</Initials></Author><Author ValidYN="Y"><LastName>Poustka</LastName><ForeName>Fritz</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Ziegler</LastName><ForeName>Andreas</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Hebebrand</LastName><ForeName>Johannes</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Bandmann</LastName><ForeName>Oliver</ForeName><Initials>O</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>9007-49-2</RegistryNumber><NameOfSubstance UI="D004247">DNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>AE28F7PNPL</RegistryNumber><NameOfSubstance UI="D008715">Methionine</NameOfSubstance></Chemical><Chemical><RegistryNumber>HG18B9YRS7</RegistryNumber><NameOfSubstance UI="D014633">Valine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019943">Amino Acid Substitution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019208">Brain-Derived Neurotrophic Factor</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002648">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004247">DNA</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000302">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D044465">European Continental Ancestry Group</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015810">Linkage Disequilibrium</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008715">Methionine</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009771">Obsessive-Compulsive Disorder</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005879">Tourette Syndrome</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014633">Valine</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>3</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>11</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>3</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.20849</ArticleId><ArticleId IdType="pubmed">16541456</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Bandmann, Oliver" sort="Bandmann, Oliver" uniqKey="Bandmann O" first="Oliver" last="Bandmann">Oliver Bandmann</name><name sortKey="Hebebrand, Johannes" sort="Hebebrand, Johannes" uniqKey="Hebebrand J" first="Johannes" last="Hebebrand">Johannes Hebebrand</name><name sortKey="Konig, Inke R" sort="Konig, Inke R" uniqKey="Konig I" first="Inke R" last="König">Inke R. König</name><name sortKey="Poustka, Fritz" sort="Poustka, Fritz" uniqKey="Poustka F" first="Fritz" last="Poustka">Fritz Poustka</name><name sortKey="Ziegler, Andreas" sort="Ziegler, Andreas" uniqKey="Ziegler A" first="Andreas" last="Ziegler">Andreas Ziegler</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Klaffke, Stefanie" sort="Klaffke, Stefanie" uniqKey="Klaffke S" first="Stefanie" last="Klaffke">Stefanie Klaffke</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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