Parkinson's disease: a broken nosology.
Identifieur interne : 001369 ( Ncbi/Curation ); précédent : 001368; suivant : 001370Parkinson's disease: a broken nosology.
Auteurs : John Hardy [États-Unis] ; Andrew J. LeesSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Nerve Tissue Proteins, Ubiquitin-Protein Ligases, alpha-Synuclein.
- genetics : Parkinson Disease.
- pathology : Lewy Bodies, Parkinson Disease, Substantia Nigra.
- physiopathology : Parkinson Disease.
- Humans, Nuclear Proteins, Repressor Proteins.
Abstract
Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the alpha-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.
DOI: 10.1002/mds.20532
PubMed: 16092073
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