MovDisordV3, Ncbi, Merge, bibRecord, 001369

Parkinson's disease: a broken nosology.

Identifieur interne : 001369 ( Ncbi/Merge ); précédent : 001368; suivant : 001370

Parkinson's disease: a broken nosology.

Auteurs : John Hardy [États-Unis] ; Andrew J. Lees

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.

RBID : pubmed:16092073

English descriptors

KwdEn :
- Humans, Lewy Bodies (pathology), Nerve Tissue Proteins (genetics), Nuclear Proteins, Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Repressor Proteins, Substantia Nigra (pathology), Ubiquitin-Protein Ligases (genetics), alpha-Synuclein (genetics).
MESH :
- chemical , genetics : Nerve Tissue Proteins, Ubiquitin-Protein Ligases, alpha-Synuclein.
- genetics : Parkinson Disease.
- pathology : Lewy Bodies, Parkinson Disease, Substantia Nigra.
- physiopathology : Parkinson Disease.
- Humans, Nuclear Proteins, Repressor Proteins.

Abstract

Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the alpha-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.

DOI: 10.1002/mds.20532
PubMed: 16092073

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pubmed:16092073

Le document en format XML

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<author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. hardyj@mail.nih.gov</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name>
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<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. hardyj@mail.nih.gov</nlm:affiliation>
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<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Repressor Proteins</term>
<term>Substantia Nigra (pathology)</term>
<term>Ubiquitin-Protein Ligases (genetics)</term>
<term>alpha-Synuclein (genetics)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term>
<term>Ubiquitin-Protein Ligases</term>
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<front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the alpha-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.</div>
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<Day>15</Day>
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<DateCompleted><Year>2005</Year>
<Month>12</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN>
<JournalIssue CitedMedium="Print"><Volume>20 Suppl 12</Volume>
<PubDate><Year>2005</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Parkinson's disease: a broken nosology.</ArticleTitle>
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<Abstract><AbstractText>Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the alpha-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.</AbstractText>
<CopyrightInformation>Copyright 2005 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hardy</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. hardyj@mail.nih.gov</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lees</LastName>
<ForeName>Andrew J</ForeName>
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<Language>eng</Language>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D051844">alpha-Synuclein</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName>
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<tree><noCountry><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name>
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<country name="États-Unis"><region name="Maryland"><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Parkinson's disease: a broken nosology.

Parkinson's disease: a broken nosology.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki