MovDisordV3, Ncbi, Curation, bibRecord, 001130

Task-dependent intracortical inhibition is impaired in focal hand dystonia

Identifieur interne : 001130 ( Ncbi/Curation ); précédent : 001129; suivant : 001131

Task-dependent intracortical inhibition is impaired in focal hand dystonia

Auteurs : Cathrin M. Bütefisch [États-Unis, Allemagne] ; Babak Boroojerdi [États-Unis] ; Robert Chen [États-Unis, Canada] ; Fortunato Battaglia [États-Unis] ; Mark Hallett [États-Unis]

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.

RBID : PMC:1457024

English descriptors

KwdEn :
- Dystonic Disorders (diagnosis), Dystonic Disorders (physiopathology), Dystonic Disorders (therapy), Electromyography, Feedback, Female, Functional Laterality (physiology), Hand (physiopathology), Humans, Magnetics (instrumentation), Male, Middle Aged, Neural Inhibition (physiology), Neural Pathways (physiopathology), Psychomotor Performance, Severity of Illness Index, Teaching (methods), Visual Perception.
MESH :
- diagnosis : Dystonic Disorders.
- instrumentation : Magnetics.
- methods : Teaching.
- physiology : Functional Laterality, Neural Inhibition.
- physiopathology : Dystonic Disorders, Hand, Neural Pathways.
- therapy : Dystonic Disorders.
- Electromyography, Feedback, Female, Humans, Male, Middle Aged, Psychomotor Performance, Severity of Illness Index, Visual Perception.

Abstract

We tested whether task-dependent modulation of inhibition within the motor cortex is impaired in patients with dystonia. Paired-pulse transcranial magnetic stimulation (TMS) at an interstimulus interval of 2 ms was used to measure the effect of two different tasks on cortical inhibition (SICI) in dystonic and normal subjects. In two experiments, SICI of the fourth dorsal interosseus (4DIO) and abductor pollicis brevis (APB) muscles were measured prior to and at the end of the training task. In the first experiment, subjects performed a nonselective task consisting of abducting the thumb, where the APB acted as agonist and the 4DIO as synergist. In the second experiment, the function of the 4DIO was changed as the subjects were asked to consciously inhibit this muscle while abducting the thumb (selective task). Therefore, while the APB was activated in both tasks, the 4DIO was activated in the nonselective task but was in the inhibitory surround in the selective task. We found that performance of the selective but not the nonselective task resulted in increased SICI in the 4DIO of normal but not in dystonic subjects. We conclude that task-dependent SICI is disturbed in patients with dystonia.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1457024

DOI: 10.1002/mds.20367
PubMed: 15641012
PubMed Central: 1457024

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PMC:1457024

Le document en format XML

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<author><name sortKey="Butefisch, Cathrin M" sort="Butefisch, Cathrin M" uniqKey="Butefisch C" first="Cathrin M." last="Bütefisch">Cathrin M. Bütefisch</name>
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<term>Electromyography</term>
<term>Feedback</term>
<term>Female</term>
<term>Functional Laterality (physiology)</term>
<term>Hand (physiopathology)</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">We tested whether task-dependent modulation of inhibition within the motor cortex is impaired in patients with dystonia. Paired-pulse transcranial magnetic stimulation (TMS) at an interstimulus interval of 2 ms was used to measure the effect of two different tasks on cortical inhibition (SICI) in dystonic and normal subjects. In two experiments, SICI of the fourth dorsal interosseus (4DIO) and abductor pollicis brevis (APB) muscles were measured prior to and at the end of the training task. In the first experiment, subjects performed a nonselective task consisting of abducting the thumb, where the APB acted as agonist and the 4DIO as synergist. In the second experiment, the function of the 4DIO was changed as the subjects were asked to consciously inhibit this muscle while abducting the thumb (selective task). Therefore, while the APB was activated in both tasks, the 4DIO was activated in the nonselective task but was in the inhibitory surround in the selective task. We found that performance of the selective but not the nonselective task resulted in increased SICI in the 4DIO of normal but not in dystonic subjects. We conclude that task-dependent SICI is disturbed in patients with dystonia.</p>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Task-dependent intracortical inhibition is impaired in focal hand dystonia

Task-dependent intracortical inhibition is impaired in focal hand dystonia

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Abstract

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