Rodent models for dystonia research: characteristics, evaluation, and utility.
Identifieur interne : 001129 ( Ncbi/Curation ); précédent : 001128; suivant : 001130Rodent models for dystonia research: characteristics, evaluation, and utility.
Auteurs : H A Jinnah [États-Unis] ; Ellen J. Hess ; Mark S. Ledoux ; Nutan Sharma ; Mark G. Baxter ; Mahlon R. DelongSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Dystonia (drug therapy), Dystonia (genetics), Dystonia (physiopathology), Evaluation Studies as Topic, Gene Expression (genetics), Gene Library, Mice, Mice, Knockout, Mice, Transgenic, Muscle, Skeletal (physiopathology), Neurodegenerative Diseases (genetics), Phenotype.
- MESH :
- drug therapy : Dystonia.
- genetics : Dystonia, Gene Expression, Neurodegenerative Diseases.
- physiopathology : Dystonia, Muscle, Skeletal.
- Animals, Disease Models, Animal, Evaluation Studies as Topic, Gene Library, Mice, Mice, Knockout, Mice, Transgenic, Phenotype.
Abstract
A large number of different genetic and acquired disorders of the nervous system may be associated with dystonia. To elucidate its pathogenesis and to facilitate the discovery of potential novel treatments, there has been a growing interest in the development of animal models and particularly rodent models. Multiple animal models for dystonia have now been developed and partially characterized. The results obtained from studies of these models often lead in very different directions, in part because the different models target different aspects of a very heterogeneous disorder. A recent workshop addressed four main issues affecting those who conduct dystonia research with animal models, including the different ways in which dystonic disorders can be modeled in rodents, key features that constitute a useful model, methods used in the evaluation of these models, and recommendations for future research. This review summarizes the main outcomes of this conference. 2005 Movement Disorder Society.
DOI: 10.1002/mds.20364
PubMed: 15641011
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :003172
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :003172
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002F74
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001129
Links to Exploration step
pubmed:15641011Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rodent models for dystonia research: characteristics, evaluation, and utility.</title><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H A" last="Jinnah">H A Jinnah</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA. hjinnah@jhmi.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287</wicri:regionArea><wicri:noRegion>Maryland 21287</wicri:noRegion></affiliation></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J" last="Hess">Ellen J. Hess</name></author><author><name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S" last="Ledoux">Mark S. Ledoux</name></author><author><name sortKey="Sharma, Nutan" sort="Sharma, Nutan" uniqKey="Sharma N" first="Nutan" last="Sharma">Nutan Sharma</name></author><author><name sortKey="Baxter, Mark G" sort="Baxter, Mark G" uniqKey="Baxter M" first="Mark G" last="Baxter">Mark G. Baxter</name></author><author><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R" last="Delong">Mahlon R. Delong</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20364</idno><idno type="RBID">pubmed:15641011</idno><idno type="pmid">15641011</idno><idno type="wicri:Area/PubMed/Corpus">003172</idno><idno type="wicri:Area/PubMed/Curation">003172</idno><idno type="wicri:Area/PubMed/Checkpoint">002F74</idno><idno type="wicri:Area/Ncbi/Merge">001129</idno><idno type="wicri:Area/Ncbi/Curation">001129</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rodent models for dystonia research: characteristics, evaluation, and utility.</title><author><name sortKey="Jinnah, H A" sort="Jinnah, H A" uniqKey="Jinnah H" first="H A" last="Jinnah">H A Jinnah</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA. hjinnah@jhmi.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287</wicri:regionArea><wicri:noRegion>Maryland 21287</wicri:noRegion></affiliation></author><author><name sortKey="Hess, Ellen J" sort="Hess, Ellen J" uniqKey="Hess E" first="Ellen J" last="Hess">Ellen J. Hess</name></author><author><name sortKey="Ledoux, Mark S" sort="Ledoux, Mark S" uniqKey="Ledoux M" first="Mark S" last="Ledoux">Mark S. Ledoux</name></author><author><name sortKey="Sharma, Nutan" sort="Sharma, Nutan" uniqKey="Sharma N" first="Nutan" last="Sharma">Nutan Sharma</name></author><author><name sortKey="Baxter, Mark G" sort="Baxter, Mark G" uniqKey="Baxter M" first="Mark G" last="Baxter">Mark G. Baxter</name></author><author><name sortKey="Delong, Mahlon R" sort="Delong, Mahlon R" uniqKey="Delong M" first="Mahlon R" last="Delong">Mahlon R. Delong</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Dystonia (drug therapy)</term><term>Dystonia (genetics)</term><term>Dystonia (physiopathology)</term><term>Evaluation Studies as Topic</term><term>Gene Expression (genetics)</term><term>Gene Library</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Muscle, Skeletal (physiopathology)</term><term>Neurodegenerative Diseases (genetics)</term><term>Phenotype</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dystonia</term><term>Gene Expression</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Evaluation Studies as Topic</term><term>Gene Library</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Phenotype</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A large number of different genetic and acquired disorders of the nervous system may be associated with dystonia. To elucidate its pathogenesis and to facilitate the discovery of potential novel treatments, there has been a growing interest in the development of animal models and particularly rodent models. Multiple animal models for dystonia have now been developed and partially characterized. The results obtained from studies of these models often lead in very different directions, in part because the different models target different aspects of a very heterogeneous disorder. A recent workshop addressed four main issues affecting those who conduct dystonia research with animal models, including the different ways in which dystonic disorders can be modeled in rodents, key features that constitute a useful model, methods used in the evaluation of these models, and recommendations for future research. This review summarizes the main outcomes of this conference. 2005 Movement Disorder Society.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001129 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 001129 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:15641011
|texte= Rodent models for dystonia research: characteristics, evaluation, and utility.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:15641011" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |