Cortical motor activation in akinetic schizophrenic patients: a pilot functional MRI study.
Identifieur interne : 000C92 ( Ncbi/Curation ); précédent : 000C91; suivant : 000C93Cortical motor activation in akinetic schizophrenic patients: a pilot functional MRI study.
Auteurs : Pierre Payoux [France] ; Kader Boulanouar ; Christine Sarramon ; Nelly Fabre ; Sylvie Descombes ; Monique Galitsky ; Claire Thalamas ; Christine Brefel-Courbon ; Umberto Sabatini ; Claude Manelfe ; François Chollet ; Laurent Schmitt ; Olivier RascolSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Brain Mapping, Dominance, Cerebral (physiology), Functional Laterality (physiology), Gyrus Cinguli (physiopathology), Hand (innervation), Humans, Hypokinesia (diagnosis), Hypokinesia (physiopathology), Hypokinesia (psychology), Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Motor Activity (physiology), Motor Cortex (physiopathology), Parietal Lobe (physiopathology), Pilot Projects, Psychiatric Status Rating Scales, Reaction Time (physiology), Reference Values, Schizophrenia (diagnosis), Schizophrenia (physiopathology), Schizophrenic Psychology, Serial Learning (physiology), Somatosensory Cortex (physiopathology).
- MESH :
- diagnosis : Hypokinesia, Schizophrenia.
- innervation : Hand.
- physiology : Dominance, Cerebral, Functional Laterality, Motor Activity, Reaction Time, Serial Learning.
- physiopathology : Gyrus Cinguli, Hypokinesia, Motor Cortex, Parietal Lobe, Schizophrenia, Somatosensory Cortex.
- psychology : Hypokinesia.
- Adult, Brain Mapping, Humans, Image Processing, Computer-Assisted, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Pilot Projects, Psychiatric Status Rating Scales, Reference Values, Schizophrenic Psychology.
Abstract
Akinesia is associated with supplementary motor area (SMA) dysfunction in Parkinson's disease. We looked for a similar association in patients with schizophrenia. Using functional magnetic resonance imaging (fMRI), we compared motor activation in 6 akinetic neuroleptic-treated schizophrenic patients and 6 normal subjects. Schizophrenic patients had a defective activation in the SMA, left primary sensorimotor cortex, bilateral lateral premotor and inferior parietal cortices, whereas the right primary sensorimotor cortex and a mesial frontal area were hyperactive. SMA was hypoactive in akinetic schizophrenic patients, emphasizing the role of this area in motor slowness. Other abnormal signals likely reflect schizophrenia-related abnormal intracortical connections.
DOI: 10.1002/mds.10598
PubMed: 14743365
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pubmed:14743365Le document en format XML
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<term>Functional Laterality (physiology)</term>
<term>Gyrus Cinguli (physiopathology)</term>
<term>Hand (innervation)</term>
<term>Humans</term>
<term>Hypokinesia (diagnosis)</term>
<term>Hypokinesia (physiopathology)</term>
<term>Hypokinesia (psychology)</term>
<term>Image Processing, Computer-Assisted</term>
<term>Imaging, Three-Dimensional</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Motor Activity (physiology)</term>
<term>Motor Cortex (physiopathology)</term>
<term>Parietal Lobe (physiopathology)</term>
<term>Pilot Projects</term>
<term>Psychiatric Status Rating Scales</term>
<term>Reaction Time (physiology)</term>
<term>Reference Values</term>
<term>Schizophrenia (diagnosis)</term>
<term>Schizophrenia (physiopathology)</term>
<term>Schizophrenic Psychology</term>
<term>Serial Learning (physiology)</term>
<term>Somatosensory Cortex (physiopathology)</term>
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<term>Schizophrenia</term>
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<term>Functional Laterality</term>
<term>Motor Activity</term>
<term>Reaction Time</term>
<term>Serial Learning</term>
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<term>Hypokinesia</term>
<term>Motor Cortex</term>
<term>Parietal Lobe</term>
<term>Schizophrenia</term>
<term>Somatosensory Cortex</term>
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<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Imaging, Three-Dimensional</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Pilot Projects</term>
<term>Psychiatric Status Rating Scales</term>
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<front><div type="abstract" xml:lang="en">Akinesia is associated with supplementary motor area (SMA) dysfunction in Parkinson's disease. We looked for a similar association in patients with schizophrenia. Using functional magnetic resonance imaging (fMRI), we compared motor activation in 6 akinetic neuroleptic-treated schizophrenic patients and 6 normal subjects. Schizophrenic patients had a defective activation in the SMA, left primary sensorimotor cortex, bilateral lateral premotor and inferior parietal cortices, whereas the right primary sensorimotor cortex and a mesial frontal area were hyperactive. SMA was hypoactive in akinetic schizophrenic patients, emphasizing the role of this area in motor slowness. Other abnormal signals likely reflect schizophrenia-related abnormal intracortical connections.</div>
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