Altered movement trajectories and force control during object transport in Huntington's disease.
Identifieur interne : 000505 ( Ncbi/Curation ); précédent : 000504; suivant : 000506Altered movement trajectories and force control during object transport in Huntington's disease.
Auteurs : L. Quinn [États-Unis] ; R. Reilmann ; K. Marder ; A M GordonSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2001.
English descriptors
- KwdEn :
- MESH :
- complications : Huntington Disease.
- etiology : Hypokinesia.
- physiopathology : Huntington Disease, Movement Disorders.
- Adult, Aged, Biomechanical Phenomena, Case-Control Studies, Female, Hand Strength, Humans, Male, Middle Aged, Movement.
Abstract
Individuals with Huntington's Disease (HD) have difficulty grasping and transporting objects, however, the extent to which specific impairments affect their performance is unknown. The present study examined the kinematics and force coordination during transport of an object in 12 subjects with HD and 12 age-matched controls. Subjects grasped an object between their thumb and index finger, transported it 25 cm forward, replaced and released it while their fingertip forces and the object's position were recorded. Five trials were performed with each of three weights (200 g, 400 g, and 800 g). While bradykinesia was evident in subjects with HD, this slowness was not consistently observed in all phases of the movement. The slowness of movement seen during the task appears to be due to impairments in sequencing and the movement strategies selected by the subjects. Compared to control subjects, subjects with HD produced highly curvilinear hand paths and more variable grip forces that were dependent on the weight of the object. Isometric force development and movement speed during transport were unaffected by the disease. The results suggest that prolonged task durations in subjects with HD are not necessarily due to slowness of movement, per se. These findings have clinical implications for understanding the task-specific nature of movement impairments in HD and developing effective intervention strategies.
PubMed: 11391741
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Altered movement trajectories and force control during object transport in Huntington's disease.</title><author><name sortKey="Quinn, L" sort="Quinn, L" uniqKey="Quinn L" first="L" last="Quinn">L. Quinn</name><affiliation wicri:level="2"><nlm:affiliation>Program in Physical Therapy, Graduate School of Health Sciences, New York Medical College, Valhalla, NY 10595, USA. lori_quinn@nymc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Physical Therapy, Graduate School of Health Sciences, New York Medical College, Valhalla, NY 10595</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Reilmann, R" sort="Reilmann, R" uniqKey="Reilmann R" first="R" last="Reilmann">R. Reilmann</name></author><author><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K" last="Marder">K. Marder</name></author><author><name sortKey="Gordon, A M" sort="Gordon, A M" uniqKey="Gordon A" first="A M" last="Gordon">A M Gordon</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11391741</idno><idno type="pmid">11391741</idno><idno type="wicri:Area/PubMed/Corpus">003D46</idno><idno type="wicri:Area/PubMed/Curation">003D46</idno><idno type="wicri:Area/PubMed/Checkpoint">003E18</idno><idno type="wicri:Area/Ncbi/Merge">000505</idno><idno type="wicri:Area/Ncbi/Curation">000505</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Altered movement trajectories and force control during object transport in Huntington's disease.</title><author><name sortKey="Quinn, L" sort="Quinn, L" uniqKey="Quinn L" first="L" last="Quinn">L. Quinn</name><affiliation wicri:level="2"><nlm:affiliation>Program in Physical Therapy, Graduate School of Health Sciences, New York Medical College, Valhalla, NY 10595, USA. lori_quinn@nymc.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Physical Therapy, Graduate School of Health Sciences, New York Medical College, Valhalla, NY 10595</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Reilmann, R" sort="Reilmann, R" uniqKey="Reilmann R" first="R" last="Reilmann">R. Reilmann</name></author><author><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K" last="Marder">K. Marder</name></author><author><name sortKey="Gordon, A M" sort="Gordon, A M" uniqKey="Gordon A" first="A M" last="Gordon">A M Gordon</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomechanical Phenomena</term><term>Case-Control Studies</term><term>Female</term><term>Hand Strength</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (physiopathology)</term><term>Hypokinesia (etiology)</term><term>Male</term><term>Middle Aged</term><term>Movement</term><term>Movement Disorders (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypokinesia</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Biomechanical Phenomena</term><term>Case-Control Studies</term><term>Female</term><term>Hand Strength</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Individuals with Huntington's Disease (HD) have difficulty grasping and transporting objects, however, the extent to which specific impairments affect their performance is unknown. The present study examined the kinematics and force coordination during transport of an object in 12 subjects with HD and 12 age-matched controls. Subjects grasped an object between their thumb and index finger, transported it 25 cm forward, replaced and released it while their fingertip forces and the object's position were recorded. Five trials were performed with each of three weights (200 g, 400 g, and 800 g). While bradykinesia was evident in subjects with HD, this slowness was not consistently observed in all phases of the movement. The slowness of movement seen during the task appears to be due to impairments in sequencing and the movement strategies selected by the subjects. Compared to control subjects, subjects with HD produced highly curvilinear hand paths and more variable grip forces that were dependent on the weight of the object. Isometric force development and movement speed during transport were unaffected by the disease. The results suggest that prolonged task durations in subjects with HD are not necessarily due to slowness of movement, per se. These findings have clinical implications for understanding the task-specific nature of movement impairments in HD and developing effective intervention strategies.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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