Neurofibrillary tangle parkinsonian disorders--tau pathology and tau genetics.
Identifieur interne : 000115 ( Ncbi/Curation ); précédent : 000114; suivant : 000116Neurofibrillary tangle parkinsonian disorders--tau pathology and tau genetics.
Auteurs : H R Morris [Royaume-Uni] ; A J Lees ; N W WoodSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1999.
English descriptors
- KwdEn :
- Brain (metabolism), Brain (pathology), Chromosome Aberrations (genetics), Chromosome Disorders, Chromosomes, Human, Pair 17 (genetics), Dementia (genetics), Genes (genetics), Humans, Neurofibrillary Tangles (genetics), Neurofibrillary Tangles (metabolism), Parkinsonian Disorders (genetics), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (pathology), Point Mutation (genetics), tau Proteins (genetics), tau Proteins (metabolism).
- MESH :
- chemical , genetics : tau Proteins.
- genetics : Chromosome Aberrations, Chromosomes, Human, Pair 17, Dementia, Genes, Neurofibrillary Tangles, Parkinsonian Disorders, Point Mutation.
- metabolism : Brain, Neurofibrillary Tangles, Parkinsonian Disorders, tau Proteins.
- pathology : Brain, Parkinsonian Disorders.
- Chromosome Disorders, Humans.
Abstract
A number of related conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration, Pick's disease, and the parkinsonism dementia complex of Guam, are characterized by the deposition of tau neurofibrillary tangles in the absence of amyloid pathology. These diseases share some overlap in their topography and clinical features but can be subdivided into three main groups according to the isoforms of the alternatively spliced tau gene that are deposited. The recent description of mutation in tau in frontotemporal dementia, and a common variant of tau that predisposes to PSP, and the relationship of these changes to the tau protein subgroups offers new insights into the pathogenesis of these disorders.
PubMed: 10495033
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :004136
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :004136
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :004163
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000115
Links to Exploration step
pubmed:10495033Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neurofibrillary tangle parkinsonian disorders--tau pathology and tau genetics.</title>
<author><name sortKey="Morris, H R" sort="Morris, H R" uniqKey="Morris H" first="H R" last="Morris">H R Morris</name>
<affiliation wicri:level="3"><nlm:affiliation>University Department of Clinical Neurology, Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University Department of Clinical Neurology, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A J" last="Lees">A J Lees</name>
</author>
<author><name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N W" last="Wood">N W Wood</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1999">1999</date>
<idno type="RBID">pubmed:10495033</idno>
<idno type="pmid">10495033</idno>
<idno type="wicri:Area/PubMed/Corpus">004136</idno>
<idno type="wicri:Area/PubMed/Curation">004136</idno>
<idno type="wicri:Area/PubMed/Checkpoint">004163</idno>
<idno type="wicri:Area/Ncbi/Merge">000115</idno>
<idno type="wicri:Area/Ncbi/Curation">000115</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Neurofibrillary tangle parkinsonian disorders--tau pathology and tau genetics.</title>
<author><name sortKey="Morris, H R" sort="Morris, H R" uniqKey="Morris H" first="H R" last="Morris">H R Morris</name>
<affiliation wicri:level="3"><nlm:affiliation>University Department of Clinical Neurology, Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University Department of Clinical Neurology, Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lees, A J" sort="Lees, A J" uniqKey="Lees A" first="A J" last="Lees">A J Lees</name>
</author>
<author><name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N W" last="Wood">N W Wood</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="1999" type="published">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (metabolism)</term>
<term>Brain (pathology)</term>
<term>Chromosome Aberrations (genetics)</term>
<term>Chromosome Disorders</term>
<term>Chromosomes, Human, Pair 17 (genetics)</term>
<term>Dementia (genetics)</term>
<term>Genes (genetics)</term>
<term>Humans</term>
<term>Neurofibrillary Tangles (genetics)</term>
<term>Neurofibrillary Tangles (metabolism)</term>
<term>Parkinsonian Disorders (genetics)</term>
<term>Parkinsonian Disorders (metabolism)</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>Point Mutation (genetics)</term>
<term>tau Proteins (genetics)</term>
<term>tau Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosome Aberrations</term>
<term>Chromosomes, Human, Pair 17</term>
<term>Dementia</term>
<term>Genes</term>
<term>Neurofibrillary Tangles</term>
<term>Parkinsonian Disorders</term>
<term>Point Mutation</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term>
<term>Neurofibrillary Tangles</term>
<term>Parkinsonian Disorders</term>
<term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Parkinsonian Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chromosome Disorders</term>
<term>Humans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">A number of related conditions, including progressive supranuclear palsy (PSP), corticobasal degeneration, Pick's disease, and the parkinsonism dementia complex of Guam, are characterized by the deposition of tau neurofibrillary tangles in the absence of amyloid pathology. These diseases share some overlap in their topography and clinical features but can be subdivided into three main groups according to the isoforms of the alternatively spliced tau gene that are deposited. The recent description of mutation in tau in frontotemporal dementia, and a common variant of tau that predisposes to PSP, and the relationship of these changes to the tau protein subgroups offers new insights into the pathogenesis of these disorders.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000115 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000115 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Ncbi |étape= Curation |type= RBID |clé= pubmed:10495033 |texte= Neurofibrillary tangle parkinsonian disorders--tau pathology and tau genetics. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:10495033" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
This area was generated with Dilib version V0.6.23. |