123I-IBZM binding compared with long-term clinical follow up in patients with de novo parkinsonism.
Identifieur interne : 004E62 ( Ncbi/Checkpoint ); précédent : 004E61; suivant : 004E63123I-IBZM binding compared with long-term clinical follow up in patients with de novo parkinsonism.
Auteurs : J. Schwarz [Allemagne] ; K. Tatsch ; T. Gasser ; G. Arnold ; O. Pogarell ; G. Künig ; W H OertelSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Apomorphine (diagnostic use), Basal Ganglia Diseases (drug therapy), Basal Ganglia Diseases (metabolism), Benzamides (diagnostic use), Benzamides (metabolism), Chi-Square Distribution, Disease Progression, Dopamine Agonists (therapeutic use), Follow-Up Studies, Humans, Iodine Radioisotopes (diagnostic use), Iodine Radioisotopes (metabolism), Levodopa (therapeutic use), Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Prognosis, Prospective Studies, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Treatment Outcome.
- MESH :
- chemical , diagnostic use : Apomorphine, Benzamides, Iodine Radioisotopes.
- drug therapy : Basal Ganglia Diseases, Parkinson Disease.
- metabolism : Basal Ganglia Diseases, Benzamides, Iodine Radioisotopes, Parkinson Disease.
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- Adult, Aged, Aged, 80 and over, Chi-Square Distribution, Disease Progression, Follow-Up Studies, Humans, Middle Aged, Prognosis, Prospective Studies, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Treatment Outcome.
Abstract
We performed a prospective clinical follow up (mean follow up, 36 months; range, 24-56 months) of 65 patients with de novo parkinsonism in whom imaging of dopamine D2 receptors was performed before the initiation of dopaminomimetic therapy by means of 123I-iodobenzamide-single-photon-emission computed tomography (IBZM-SPECT). The results of IBZM-SPECT were compared with the long-term response to dopaminomimetic drugs, the development of motor fluctuations, and the development of clinical signs incompatible with Parkinson's disease (PD). A total of 55 patients had normal and 10 patients had reduced IBZM binding; 45 patients showed a good response to levodopa (L-dopa), 11 showed an equivocal response, and nine did not respond; 31 patients developed a fluctuating response to dopaminomimetic drugs and seven patients developed clinical signs indicative of multiple-system atrophy (n = 5), progressive supranuclear palsy (n = 1), or corticobasal ganglionic degeneration (n = 1). Chi-squared analysis showed a significant correlation of the results of IBZM-SPECT with the long-term response to dopaminomimetic therapy (p < 0.0001) and the development of motor fluctuations (p < 0.001) or clinical signs incompatible with PD (p < 0.0001). We conclude that IBZM-SPECT can help to differentiate between patients who will show a good response to L-dopa and will develop motor fluctuations (most likely patients with PD) and those patients who will not respond to L-dopa and might develop clinical signs compatible with another hypokinetic disorder of the basal ganglia.
DOI: 10.1002/mds.870130107
PubMed: 9452320
Affiliations:
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Tatsch</name></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name></author><author><name sortKey="Arnold, G" sort="Arnold, G" uniqKey="Arnold G" first="G" last="Arnold">G. Arnold</name></author><author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O" last="Pogarell">O. Pogarell</name></author><author><name sortKey="Kunig, G" sort="Kunig, G" uniqKey="Kunig G" first="G" last="Künig">G. Künig</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1998">1998</date><idno type="RBID">pubmed:9452320</idno><idno type="pmid">9452320</idno><idno type="doi">10.1002/mds.870130107</idno><idno type="wicri:Area/PubMed/Corpus">004523</idno><idno type="wicri:Area/PubMed/Curation">004523</idno><idno type="wicri:Area/PubMed/Checkpoint">004524</idno><idno type="wicri:Area/Ncbi/Merge">004E62</idno><idno type="wicri:Area/Ncbi/Curation">004E62</idno><idno type="wicri:Area/Ncbi/Checkpoint">004E62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">123I-IBZM binding compared with long-term clinical follow up in patients with de novo parkinsonism.</title><author><name sortKey="Schwarz, J" sort="Schwarz, J" uniqKey="Schwarz J" first="J" last="Schwarz">J. Schwarz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Tatsch, K" sort="Tatsch, K" uniqKey="Tatsch K" first="K" last="Tatsch">K. Tatsch</name></author><author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name></author><author><name sortKey="Arnold, G" sort="Arnold, G" uniqKey="Arnold G" first="G" last="Arnold">G. Arnold</name></author><author><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O" last="Pogarell">O. Pogarell</name></author><author><name sortKey="Kunig, G" sort="Kunig, G" uniqKey="Kunig G" first="G" last="Künig">G. Künig</name></author><author><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1998" type="published">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Apomorphine (diagnostic use)</term><term>Basal Ganglia Diseases (drug therapy)</term><term>Basal Ganglia Diseases (metabolism)</term><term>Benzamides (diagnostic use)</term><term>Benzamides (metabolism)</term><term>Chi-Square Distribution</term><term>Disease Progression</term><term>Dopamine Agonists (therapeutic use)</term><term>Follow-Up Studies</term><term>Humans</term><term>Iodine Radioisotopes (diagnostic use)</term><term>Iodine Radioisotopes (metabolism)</term><term>Levodopa (therapeutic use)</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (metabolism)</term><term>Prognosis</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Apomorphine</term><term>Benzamides</term><term>Iodine Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Benzamides</term><term>Iodine Radioisotopes</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Chi-Square Distribution</term><term>Disease Progression</term><term>Follow-Up Studies</term><term>Humans</term><term>Middle Aged</term><term>Prognosis</term><term>Prospective Studies</term><term>Severity of Illness Index</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a prospective clinical follow up (mean follow up, 36 months; range, 24-56 months) of 65 patients with de novo parkinsonism in whom imaging of dopamine D2 receptors was performed before the initiation of dopaminomimetic therapy by means of 123I-iodobenzamide-single-photon-emission computed tomography (IBZM-SPECT). The results of IBZM-SPECT were compared with the long-term response to dopaminomimetic drugs, the development of motor fluctuations, and the development of clinical signs incompatible with Parkinson's disease (PD). A total of 55 patients had normal and 10 patients had reduced IBZM binding; 45 patients showed a good response to levodopa (L-dopa), 11 showed an equivocal response, and nine did not respond; 31 patients developed a fluctuating response to dopaminomimetic drugs and seven patients developed clinical signs indicative of multiple-system atrophy (n = 5), progressive supranuclear palsy (n = 1), or corticobasal ganglionic degeneration (n = 1). Chi-squared analysis showed a significant correlation of the results of IBZM-SPECT with the long-term response to dopaminomimetic therapy (p < 0.0001) and the development of motor fluctuations (p < 0.001) or clinical signs incompatible with PD (p < 0.0001). We conclude that IBZM-SPECT can help to differentiate between patients who will show a good response to L-dopa and will develop motor fluctuations (most likely patients with PD) and those patients who will not respond to L-dopa and might develop clinical signs compatible with another hypokinetic disorder of the basal ganglia.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><noCountry><name sortKey="Arnold, G" sort="Arnold, G" uniqKey="Arnold G" first="G" last="Arnold">G. Arnold</name><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T" last="Gasser">T. Gasser</name><name sortKey="Kunig, G" sort="Kunig, G" uniqKey="Kunig G" first="G" last="Künig">G. Künig</name><name sortKey="Oertel, W H" sort="Oertel, W H" uniqKey="Oertel W" first="W H" last="Oertel">W H Oertel</name><name sortKey="Pogarell, O" sort="Pogarell, O" uniqKey="Pogarell O" first="O" last="Pogarell">O. Pogarell</name><name sortKey="Tatsch, K" sort="Tatsch, K" uniqKey="Tatsch K" first="K" last="Tatsch">K. Tatsch</name></noCountry><country name="Allemagne"><region name="Bavière"><name sortKey="Schwarz, J" sort="Schwarz, J" uniqKey="Schwarz J" first="J" last="Schwarz">J. Schwarz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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