123I-IBZM binding compared with long-term clinical follow up in patients with de novo parkinsonism.
Identifieur interne : 004524 ( PubMed/Checkpoint ); précédent : 004523; suivant : 004525123I-IBZM binding compared with long-term clinical follow up in patients with de novo parkinsonism.
Auteurs : J. Schwarz [Allemagne] ; K. Tatsch ; T. Gasser ; G. Arnold ; O. Pogarell ; G. Künig ; W H OertelSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 1998.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Apomorphine (diagnostic use), Basal Ganglia Diseases (drug therapy), Basal Ganglia Diseases (metabolism), Benzamides (diagnostic use), Benzamides (metabolism), Chi-Square Distribution, Disease Progression, Dopamine Agonists (therapeutic use), Follow-Up Studies, Humans, Iodine Radioisotopes (diagnostic use), Iodine Radioisotopes (metabolism), Levodopa (therapeutic use), Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Prognosis, Prospective Studies, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Treatment Outcome.
- MESH :
- chemical , diagnostic use : Apomorphine, Benzamides, Iodine Radioisotopes.
- drug therapy : Basal Ganglia Diseases, Parkinson Disease.
- metabolism : Basal Ganglia Diseases, Benzamides, Iodine Radioisotopes, Parkinson Disease.
- chemical , therapeutic use : Dopamine Agonists, Levodopa.
- Adult, Aged, Aged, 80 and over, Chi-Square Distribution, Disease Progression, Follow-Up Studies, Humans, Middle Aged, Prognosis, Prospective Studies, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon, Treatment Outcome.
Abstract
We performed a prospective clinical follow up (mean follow up, 36 months; range, 24-56 months) of 65 patients with de novo parkinsonism in whom imaging of dopamine D2 receptors was performed before the initiation of dopaminomimetic therapy by means of 123I-iodobenzamide-single-photon-emission computed tomography (IBZM-SPECT). The results of IBZM-SPECT were compared with the long-term response to dopaminomimetic drugs, the development of motor fluctuations, and the development of clinical signs incompatible with Parkinson's disease (PD). A total of 55 patients had normal and 10 patients had reduced IBZM binding; 45 patients showed a good response to levodopa (L-dopa), 11 showed an equivocal response, and nine did not respond; 31 patients developed a fluctuating response to dopaminomimetic drugs and seven patients developed clinical signs indicative of multiple-system atrophy (n = 5), progressive supranuclear palsy (n = 1), or corticobasal ganglionic degeneration (n = 1). Chi-squared analysis showed a significant correlation of the results of IBZM-SPECT with the long-term response to dopaminomimetic therapy (p < 0.0001) and the development of motor fluctuations (p < 0.001) or clinical signs incompatible with PD (p < 0.0001). We conclude that IBZM-SPECT can help to differentiate between patients who will show a good response to L-dopa and will develop motor fluctuations (most likely patients with PD) and those patients who will not respond to L-dopa and might develop clinical signs compatible with another hypokinetic disorder of the basal ganglia.
DOI: 10.1002/mds.870130107
PubMed: 9452320
Affiliations:
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pubmed:9452320Le document en format XML
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<author><name sortKey="Arnold, G" sort="Arnold, G" uniqKey="Arnold G" first="G" last="Arnold">G. Arnold</name>
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<term>Aged</term>
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<term>Apomorphine (diagnostic use)</term>
<term>Basal Ganglia Diseases (drug therapy)</term>
<term>Basal Ganglia Diseases (metabolism)</term>
<term>Benzamides (diagnostic use)</term>
<term>Benzamides (metabolism)</term>
<term>Chi-Square Distribution</term>
<term>Disease Progression</term>
<term>Dopamine Agonists (therapeutic use)</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Iodine Radioisotopes (diagnostic use)</term>
<term>Iodine Radioisotopes (metabolism)</term>
<term>Levodopa (therapeutic use)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Prognosis</term>
<term>Prospective Studies</term>
<term>Severity of Illness Index</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Apomorphine</term>
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<term>Benzamides</term>
<term>Iodine Radioisotopes</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term>
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<front><div type="abstract" xml:lang="en">We performed a prospective clinical follow up (mean follow up, 36 months; range, 24-56 months) of 65 patients with de novo parkinsonism in whom imaging of dopamine D2 receptors was performed before the initiation of dopaminomimetic therapy by means of 123I-iodobenzamide-single-photon-emission computed tomography (IBZM-SPECT). The results of IBZM-SPECT were compared with the long-term response to dopaminomimetic drugs, the development of motor fluctuations, and the development of clinical signs incompatible with Parkinson's disease (PD). A total of 55 patients had normal and 10 patients had reduced IBZM binding; 45 patients showed a good response to levodopa (L-dopa), 11 showed an equivocal response, and nine did not respond; 31 patients developed a fluctuating response to dopaminomimetic drugs and seven patients developed clinical signs indicative of multiple-system atrophy (n = 5), progressive supranuclear palsy (n = 1), or corticobasal ganglionic degeneration (n = 1). Chi-squared analysis showed a significant correlation of the results of IBZM-SPECT with the long-term response to dopaminomimetic therapy (p < 0.0001) and the development of motor fluctuations (p < 0.001) or clinical signs incompatible with PD (p < 0.0001). We conclude that IBZM-SPECT can help to differentiate between patients who will show a good response to L-dopa and will develop motor fluctuations (most likely patients with PD) and those patients who will not respond to L-dopa and might develop clinical signs compatible with another hypokinetic disorder of the basal ganglia.</div>
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<ArticleTitle>123I-IBZM binding compared with long-term clinical follow up in patients with de novo parkinsonism.</ArticleTitle>
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<Abstract><AbstractText>We performed a prospective clinical follow up (mean follow up, 36 months; range, 24-56 months) of 65 patients with de novo parkinsonism in whom imaging of dopamine D2 receptors was performed before the initiation of dopaminomimetic therapy by means of 123I-iodobenzamide-single-photon-emission computed tomography (IBZM-SPECT). The results of IBZM-SPECT were compared with the long-term response to dopaminomimetic drugs, the development of motor fluctuations, and the development of clinical signs incompatible with Parkinson's disease (PD). A total of 55 patients had normal and 10 patients had reduced IBZM binding; 45 patients showed a good response to levodopa (L-dopa), 11 showed an equivocal response, and nine did not respond; 31 patients developed a fluctuating response to dopaminomimetic drugs and seven patients developed clinical signs indicative of multiple-system atrophy (n = 5), progressive supranuclear palsy (n = 1), or corticobasal ganglionic degeneration (n = 1). Chi-squared analysis showed a significant correlation of the results of IBZM-SPECT with the long-term response to dopaminomimetic therapy (p < 0.0001) and the development of motor fluctuations (p < 0.001) or clinical signs incompatible with PD (p < 0.0001). We conclude that IBZM-SPECT can help to differentiate between patients who will show a good response to L-dopa and will develop motor fluctuations (most likely patients with PD) and those patients who will not respond to L-dopa and might develop clinical signs compatible with another hypokinetic disorder of the basal ganglia.</AbstractText>
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