Metabolic Markers or Conditions Preceding Parkinson’s Disease: A Case-Control Study
Identifieur interne : 003688 ( Ncbi/Checkpoint ); précédent : 003687; suivant : 003689Metabolic Markers or Conditions Preceding Parkinson’s Disease: A Case-Control Study
Auteurs : Rodolfo Savica [États-Unis] ; Brandon R. Grossardt [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Walter A. Rocca [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Biological Markers, Body Mass Index, Case-Control Studies, Cholesterol (blood), Coffee, Data Interpretation, Statistical, Diabetes Mellitus (epidemiology), Female, Humans, Hypertension (complications), Male, Medical Record Linkage, Middle Aged, Minnesota (epidemiology), Odds Ratio, Parkinson Disease (complications), Parkinson Disease (epidemiology), Parkinson Disease (metabolism), Reproducibility of Results, Risk Assessment, Sex Factors, Smoking (epidemiology).
- MESH :
- chemical , blood : Cholesterol.
- chemical : Biological Markers, Coffee.
- geographic , epidemiology : Minnesota.
- complications : Hypertension, Parkinson Disease.
- epidemiology : Diabetes Mellitus, Parkinson Disease, Smoking.
- metabolism : Parkinson Disease.
- Aged, Body Mass Index, Case-Control Studies, Data Interpretation, Statistical, Female, Humans, Male, Medical Record Linkage, Middle Aged, Odds Ratio, Reproducibility of Results, Risk Assessment, Sex Factors.
Abstract
Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson’s disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design.
We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (± 1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol levels, hypertension, and diabetes mellitus preceding the onset of PD (or the index year).
There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cut-offs for BMI levels (BMI ≥ 25 or BMI ≥ 30 kg/m2) and 3 cut-offs for cholesterol levels (> 200, > 250, or > 300 mg/dl). A diagnosis of hypertension or the documented use of anti-hypertensive medications were not significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65–1.54;
Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol levels, hypertension, or diabetes mellitus and later development of PD.
Url:
DOI: 10.1002/mds.25016
PubMed: 22674432
PubMed Central: 3539719
Affiliations:
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Grossardt</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Biological Markers</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Cholesterol (blood)</term><term>Coffee</term><term>Data Interpretation, Statistical</term><term>Diabetes Mellitus (epidemiology)</term><term>Female</term><term>Humans</term><term>Hypertension (complications)</term><term>Male</term><term>Medical Record Linkage</term><term>Middle Aged</term><term>Minnesota (epidemiology)</term><term>Odds Ratio</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (metabolism)</term><term>Reproducibility of Results</term><term>Risk Assessment</term><term>Sex Factors</term><term>Smoking (epidemiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cholesterol</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biological Markers</term><term>Coffee</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Minnesota</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hypertension</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Diabetes Mellitus</term><term>Parkinson Disease</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Body Mass Index</term><term>Case-Control Studies</term><term>Data Interpretation, Statistical</term><term>Female</term><term>Humans</term><term>Male</term><term>Medical Record Linkage</term><term>Middle Aged</term><term>Odds Ratio</term><term>Reproducibility of Results</term><term>Risk Assessment</term><term>Sex Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson’s disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (± 1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol levels, hypertension, and diabetes mellitus preceding the onset of PD (or the index year).</p></sec><sec id="S3"><title>Results</title><p id="P3">There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cut-offs for BMI levels (BMI ≥ 25 or BMI ≥ 30 kg/m<sup>2</sup>) and 3 cut-offs for cholesterol levels (> 200, > 250, or > 300 mg/dl). A diagnosis of hypertension or the documented use of anti-hypertensive medications were not significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65–1.54; <italic>P</italic> = .99), nor was a diagnosis of diabetes mellitus or the use of glucose-lowering medications (OR, 0.77; 95% CI, 0.37–1.57; <italic>P</italic> =.47).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol levels, hypertension, or diabetes mellitus and later development of PD.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Savica, Rodolfo" sort="Savica, Rodolfo" uniqKey="Savica R" first="Rodolfo" last="Savica">Rodolfo Savica</name></region><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R." last="Grossardt">Brandon R. Grossardt</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Savica, Rodolfo" sort="Savica, Rodolfo" uniqKey="Savica R" first="Rodolfo" last="Savica">Rodolfo Savica</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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