Metabolic Markers or Conditions Preceding Parkinson’s Disease: A Case-Control Study
Identifieur interne : 000178 ( Pmc/Checkpoint ); précédent : 000177; suivant : 000179Metabolic Markers or Conditions Preceding Parkinson’s Disease: A Case-Control Study
Auteurs : Rodolfo Savica [États-Unis] ; Brandon R. Grossardt [États-Unis] ; J. Eric Ahlskog [États-Unis] ; Walter A. Rocca [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2012.
Abstract
Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson’s disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design.
We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (± 1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol levels, hypertension, and diabetes mellitus preceding the onset of PD (or the index year).
There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cut-offs for BMI levels (BMI ≥ 25 or BMI ≥ 30 kg/m2) and 3 cut-offs for cholesterol levels (> 200, > 250, or > 300 mg/dl). A diagnosis of hypertension or the documented use of anti-hypertensive medications were not significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65–1.54;
Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol levels, hypertension, or diabetes mellitus and later development of PD.
Url:
DOI: 10.1002/mds.25016
PubMed: 22674432
PubMed Central: 3539719
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Grossardt</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22674432</idno><idno type="pmc">3539719</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539719</idno><idno type="RBID">PMC:3539719</idno><idno type="doi">10.1002/mds.25016</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000267</idno><idno type="wicri:Area/Pmc/Curation">000267</idno><idno type="wicri:Area/Pmc/Checkpoint">000178</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Metabolic Markers or Conditions Preceding Parkinson’s Disease: A Case-Control Study</title><author><name sortKey="Savica, Rodolfo" sort="Savica, Rodolfo" uniqKey="Savica R" first="Rodolfo" last="Savica">Rodolfo Savica</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R." last="Grossardt">Brandon R. Grossardt</name><affiliation wicri:level="2"><nlm:aff id="A3">Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson’s disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (± 1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol levels, hypertension, and diabetes mellitus preceding the onset of PD (or the index year).</p></sec><sec id="S3"><title>Results</title><p id="P3">There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cut-offs for BMI levels (BMI ≥ 25 or BMI ≥ 30 kg/m<sup>2</sup>) and 3 cut-offs for cholesterol levels (> 200, > 250, or > 300 mg/dl). A diagnosis of hypertension or the documented use of anti-hypertensive medications were not significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65–1.54; <italic>P</italic> = .99), nor was a diagnosis of diabetes mellitus or the use of glucose-lowering medications (OR, 0.77; 95% CI, 0.37–1.57; <italic>P</italic> =.47).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol levels, hypertension, or diabetes mellitus and later development of PD.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8610688</journal-id><journal-id journal-id-type="pubmed-jr-id">5937</journal-id><journal-id journal-id-type="nlm-ta">Mov Disord</journal-id><journal-id journal-id-type="iso-abbrev">Mov. Disord.</journal-id><journal-title-group><journal-title>Movement disorders : official journal of the Movement Disorder Society</journal-title></journal-title-group><issn pub-type="ppub">0885-3185</issn><issn pub-type="epub">1531-8257</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22674432</article-id><article-id pub-id-type="pmc">3539719</article-id><article-id pub-id-type="doi">10.1002/mds.25016</article-id><article-id pub-id-type="manuscript">NIHMS431433</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Metabolic Markers or Conditions Preceding Parkinson’s Disease: A Case-Control Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Savica</surname><given-names>Rodolfo</given-names></name><degrees>MD, MSc</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Grossardt</surname><given-names>Brandon R.</given-names></name><degrees>MS</degrees><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Ahlskog</surname><given-names>J. Eric</given-names></name><degrees>PhD, MD</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rocca</surname><given-names>Walter A.</given-names></name><degrees>MD, MPH</degrees><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="CR1">*</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A2"><label>2</label>Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</aff><aff id="A3"><label>3</label>Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA</aff><author-notes><corresp id="CR1"><label>*</label><bold>Correspondence to:</bold> Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; [telephone: (507) 284-3568; fax: (507) 284-1516; <email>rocca@mayo.edu</email>].
</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>01</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2013</year></pub-date><volume>27</volume><issue>8</issue><fpage>974</fpage><lpage>979</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Several metabolic markers or conditions have been explored as possible risk or protective factors for Parkinson’s disease (PD); however, results remain conflicting. We further investigated these associations using a case-control study design.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We used the medical records-linkage system of the Rochester Epidemiology Project to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched by age (± 1 year) and sex to a general population control. We reviewed the complete medical records of cases and controls in the medical records-linkage system to abstract information about body mass index (BMI), cholesterol levels, hypertension, and diabetes mellitus preceding the onset of PD (or the index year).</p></sec><sec id="S3"><title>Results</title><p id="P3">There were no significant differences between cases and controls for the metabolic markers or conditions investigated. No significant associations were found using 2 cut-offs for BMI levels (BMI ≥ 25 or BMI ≥ 30 kg/m<sup>2</sup>) and 3 cut-offs for cholesterol levels (> 200, > 250, or > 300 mg/dl). A diagnosis of hypertension or the documented use of anti-hypertensive medications were not significantly associated with the subsequent risk of PD (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.65–1.54; <italic>P</italic> = .99), nor was a diagnosis of diabetes mellitus or the use of glucose-lowering medications (OR, 0.77; 95% CI, 0.37–1.57; <italic>P</italic> =.47).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Our study, based on historical information from a records-linkage system, does not support an association between BMI, cholesterol levels, hypertension, or diabetes mellitus and later development of PD.</p></sec></abstract><kwd-group><kwd>Parkinson’s disease</kwd><kwd>body mass index</kwd><kwd>cholesterol level</kwd><kwd>hypertension</kwd><kwd>diabetes mellitus</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source><award-id>R01 NS033978 || NS</award-id></award-group><award-group><funding-source country="United States">National Institute on Aging : NIA</funding-source><award-id>R01 AG034676 || AG</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Minnesota</li></region></list><tree><country name="États-Unis"><region name="Minnesota"><name sortKey="Savica, Rodolfo" sort="Savica, Rodolfo" uniqKey="Savica R" first="Rodolfo" last="Savica">Rodolfo Savica</name></region><name sortKey="Ahlskog, J Eric" sort="Ahlskog, J Eric" uniqKey="Ahlskog J" first="J. Eric" last="Ahlskog">J. Eric Ahlskog</name><name sortKey="Grossardt, Brandon R" sort="Grossardt, Brandon R" uniqKey="Grossardt B" first="Brandon R." last="Grossardt">Brandon R. Grossardt</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Rocca, Walter A" sort="Rocca, Walter A" uniqKey="Rocca W" first="Walter A." last="Rocca">Walter A. Rocca</name><name sortKey="Savica, Rodolfo" sort="Savica, Rodolfo" uniqKey="Savica R" first="Rodolfo" last="Savica">Rodolfo Savica</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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