Movement Disorders (revue)

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Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: clinicopathological case.

Identifieur interne : 003087 ( Ncbi/Checkpoint ); précédent : 003086; suivant : 003088

Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: clinicopathological case.

Auteurs : Giovanni Fabbrini [Italie] ; Marcello Merello ; Andrew H. Evans ; Andrew J. Lees ; Janice Holton ; David R. Williams

Source :

RBID : pubmed:21462257

English descriptors

Abstract

A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.

DOI: 10.1002/mds.23302
PubMed: 21462257


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pubmed:21462257

Le document en format XML

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<nlm:affiliation>Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Italy.</nlm:affiliation>
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<name sortKey="Merello, Marcello" sort="Merello, Marcello" uniqKey="Merello M" first="Marcello" last="Merello">Marcello Merello</name>
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<term>Female</term>
<term>Humans</term>
<term>Inclusion Bodies (pathology)</term>
<term>Middle Aged</term>
<term>Ocular Motility Disorders (complications)</term>
<term>Ocular Motility Disorders (pathology)</term>
<term>Parkinsonian Disorders (complications)</term>
<term>Parkinsonian Disorders (pathology)</term>
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<div type="abstract" xml:lang="en">A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.</div>
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<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name>
<name sortKey="Merello, Marcello" sort="Merello, Marcello" uniqKey="Merello M" first="Marcello" last="Merello">Marcello Merello</name>
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