Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: clinicopathological case.
Identifieur interne : 003087 ( Ncbi/Checkpoint ); précédent : 003086; suivant : 003088Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: clinicopathological case.
Auteurs : Giovanni Fabbrini [Italie] ; Marcello Merello ; Andrew H. Evans ; Andrew J. Lees ; Janice Holton ; David R. WilliamsSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2011.
English descriptors
- KwdEn :
- Autonomic Nervous System Diseases (complications), Autonomic Nervous System Diseases (pathology), Disease Progression, Female, Humans, Inclusion Bodies (pathology), Middle Aged, Ocular Motility Disorders (complications), Ocular Motility Disorders (pathology), Parkinsonian Disorders (complications), Parkinsonian Disorders (pathology), Putamen (pathology).
- MESH :
Abstract
A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.
DOI: 10.1002/mds.23302
PubMed: 21462257
Affiliations:
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pubmed:21462257Le document en format XML
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<author><name sortKey="Merello, Marcello" sort="Merello, Marcello" uniqKey="Merello M" first="Marcello" last="Merello">Marcello Merello</name>
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<author><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H" last="Evans">Andrew H. Evans</name>
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<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name>
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<author><name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R" last="Williams">David R. Williams</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
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<term>Humans</term>
<term>Inclusion Bodies (pathology)</term>
<term>Middle Aged</term>
<term>Ocular Motility Disorders (complications)</term>
<term>Ocular Motility Disorders (pathology)</term>
<term>Parkinsonian Disorders (complications)</term>
<term>Parkinsonian Disorders (pathology)</term>
<term>Putamen (pathology)</term>
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<term>Inclusion Bodies</term>
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<term>Parkinsonian Disorders</term>
<term>Putamen</term>
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<front><div type="abstract" xml:lang="en">A 59-year-old woman presented with asymmetric parkinsonism that was not-responsive to Levodopa therapy. She developed early falls, postural instability, and moderately severe autonomic dysfunction. Eye movement abnormalities were reported 2 years after her first symptoms, and she eventually developed anterocollis. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered.</div>
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<affiliations><list><country><li>Italie</li>
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<tree><noCountry><name sortKey="Evans, Andrew H" sort="Evans, Andrew H" uniqKey="Evans A" first="Andrew H" last="Evans">Andrew H. Evans</name>
<name sortKey="Holton, Janice" sort="Holton, Janice" uniqKey="Holton J" first="Janice" last="Holton">Janice Holton</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name>
<name sortKey="Merello, Marcello" sort="Merello, Marcello" uniqKey="Merello M" first="Marcello" last="Merello">Marcello Merello</name>
<name sortKey="Williams, David R" sort="Williams, David R" uniqKey="Williams D" first="David R" last="Williams">David R. Williams</name>
</noCountry>
<country name="Italie"><noRegion><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name>
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