Impact of belief in neuroprotection on therapeutic intervention in Parkinson disease
Identifieur interne : 002A11 ( Ncbi/Checkpoint ); précédent : 002A10; suivant : 002A12Impact of belief in neuroprotection on therapeutic intervention in Parkinson disease
Auteurs : Rodger J. Elble ; Oksana Suchowersky [Canada] ; Stephanie Shaftman ; William J. Weiner ; Peng Huang ; Barbara TilleySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
- Adult, Aged, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Neuroprotective Agents (therapeutic use), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Randomized Controlled Trials as Topic, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome, Ubiquinone (therapeutic use).
- MESH :
- chemical , therapeutic use : Neuroprotective Agents, Ubiquinone.
- drug therapy : Parkinson Disease.
- psychology : Parkinson Disease.
- Adult, Aged, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Randomized Controlled Trials as Topic, Severity of Illness Index, Statistics, Nonparametric, Treatment Outcome.
Abstract
We explored the hypotheses that an investigator’s belief in a putative neuroprotective agent might influence the timing of symptomatic intervention and the assessment of signs and symptoms of Parkinson patients with the Unified Parkinson Disease Rating Scale (UPDRS). These hypotheses were tested with Cox and general linear modeling, using data from a previously published double-blind placebo-controlled futility trial of coenzyme Q10 and GPI-1485. We found the investigators’ level of confidence in these agents had no effect on the time to symptomatic therapy or on the change in UPDRS during 12 months of treatment.
Url:
DOI: 10.1002/mds.22997
PubMed: 20131372
PubMed Central: 2891220
Affiliations:
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PMC:2891220Le document en format XML
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<author><name sortKey="Weiner, William J" sort="Weiner, William J" uniqKey="Weiner W" first="William J." last="Weiner">William J. Weiner</name>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Parkinson Disease (psychology)</term>
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<term>Statistics, Nonparametric</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">We explored the hypotheses that an investigator’s belief in a putative neuroprotective agent might influence the timing of symptomatic intervention and the assessment of signs and symptoms of Parkinson patients with the Unified Parkinson Disease Rating Scale (UPDRS). These hypotheses were tested with Cox and general linear modeling, using data from a previously published double-blind placebo-controlled futility trial of coenzyme Q<sub>10</sub>
and GPI-1485. We found the investigators’ level of confidence in these agents had no effect on the time to symptomatic therapy or on the change in UPDRS during 12 months of treatment.</p>
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</front>
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<affiliations><list><country><li>Canada</li>
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<region><li>Alberta</li>
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<orgName><li>Université de Calgary</li>
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<tree><noCountry><name sortKey="Elble, Rodger J" sort="Elble, Rodger J" uniqKey="Elble R" first="Rodger J." last="Elble">Rodger J. Elble</name>
<name sortKey="Huang, Peng" sort="Huang, Peng" uniqKey="Huang P" first="Peng" last="Huang">Peng Huang</name>
<name sortKey="Shaftman, Stephanie" sort="Shaftman, Stephanie" uniqKey="Shaftman S" first="Stephanie" last="Shaftman">Stephanie Shaftman</name>
<name sortKey="Tilley, Barbara" sort="Tilley, Barbara" uniqKey="Tilley B" first="Barbara" last="Tilley">Barbara Tilley</name>
<name sortKey="Weiner, William J" sort="Weiner, William J" uniqKey="Weiner W" first="William J." last="Weiner">William J. Weiner</name>
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<country name="Canada"><region name="Alberta"><name sortKey="Suchowersky, Oksana" sort="Suchowersky, Oksana" uniqKey="Suchowersky O" first="Oksana" last="Suchowersky">Oksana Suchowersky</name>
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