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Movement Disorders (revue)

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Impact of belief in neuroprotection on therapeutic intervention in Parkinson disease

Identifieur interne : 000082 ( Pmc/Corpus ); précédent : 000081; suivant : 000083

Impact of belief in neuroprotection on therapeutic intervention in Parkinson disease

Auteurs : Rodger J. Elble ; Oksana Suchowersky ; Stephanie Shaftman ; William J. Weiner ; Peng Huang ; Barbara Tilley

Source :

RBID : PMC:2891220

Abstract

We explored the hypotheses that an investigator’s belief in a putative neuroprotective agent might influence the timing of symptomatic intervention and the assessment of signs and symptoms of Parkinson patients with the Unified Parkinson Disease Rating Scale (UPDRS). These hypotheses were tested with Cox and general linear modeling, using data from a previously published double-blind placebo-controlled futility trial of coenzyme Q10 and GPI-1485. We found the investigators’ level of confidence in these agents had no effect on the time to symptomatic therapy or on the change in UPDRS during 12 months of treatment.


Url:
DOI: 10.1002/mds.22997
PubMed: 20131372
PubMed Central: 2891220

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