Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment.
Identifieur interne : 002963 ( Ncbi/Checkpoint ); précédent : 002962; suivant : 002964Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment.
Auteurs : Raquel Duran [Espagne] ; Francisco J. Barrero ; Blas Morales ; Juan D. Luna ; Manuel Ramirez ; Francisco VivesSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Drug Therapy (statistics & numerical data), Enzyme-Linked Immunosorbent Assay, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), alpha-Synuclein (blood).
- MESH :
- chemical , blood : alpha-Synuclein.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood : Parkinson Disease.
- drug therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- statistics & numerical data : Drug Therapy.
- Aged, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged.
Abstract
Alpha-synuclein (alpha-syn) is an intracellular protein with a high tendency to aggregation. It is the major component of Lewy bodies and may play a key role in the pathogenesis of Parkinson's disease (PD). alpha-Syn is also released by neurons and can be detected in biological fluids, such as plasma. The purpose of this study was to determine whether plasma alpha-syn concentrations are elevated in newly diagnosed PD patients before treatment (nontreated PD group, ntPD; n = 53) and to compare them with concentrations in PD patients with at least 1 year of specific treatment (tPD; n = 42) and in healthy controls (n = 60). Plasma alpha-syn concentrations in the ntPD and tPD groups were similar and significantly higher than in healthy controls. In conclusion, alpha-syn was elevated early in the development of PD and specific PD treatment did not change plasma alpha-syn levels.
DOI: 10.1002/mds.22928
PubMed: 20063406
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment.</title><author><name sortKey="Duran, Raquel" sort="Duran, Raquel" uniqKey="Duran R" first="Raquel" last="Duran">Raquel Duran</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology and Institute of Neurosciences, Centro de Investigaciones Biomedicas (CIBM), University of Granada, Granada, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Physiology and Institute of Neurosciences, Centro de Investigaciones Biomedicas (CIBM), University of Granada, Granada</wicri:regionArea><orgName type="university">Université de Grenade</orgName><placeName><settlement type="city">Grenade (Espagne)</settlement><region nuts="2" type="region">Andalousie</region></placeName></affiliation></author><author><name sortKey="Barrero, Francisco J" sort="Barrero, Francisco J" uniqKey="Barrero F" first="Francisco J" last="Barrero">Francisco J. Barrero</name></author><author><name sortKey="Morales, Blas" sort="Morales, Blas" uniqKey="Morales B" first="Blas" last="Morales">Blas Morales</name></author><author><name sortKey="Luna, Juan D" sort="Luna, Juan D" uniqKey="Luna J" first="Juan D" last="Luna">Juan D. Luna</name></author><author><name sortKey="Ramirez, Manuel" sort="Ramirez, Manuel" uniqKey="Ramirez M" first="Manuel" last="Ramirez">Manuel Ramirez</name></author><author><name sortKey="Vives, Francisco" sort="Vives, Francisco" uniqKey="Vives F" first="Francisco" last="Vives">Francisco Vives</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1002/mds.22928</idno><idno type="RBID">pubmed:20063406</idno><idno type="pmid">20063406</idno><idno type="wicri:Area/PubMed/Corpus">001A39</idno><idno type="wicri:Area/PubMed/Curation">001A39</idno><idno type="wicri:Area/PubMed/Checkpoint">001701</idno><idno type="wicri:Area/Ncbi/Merge">002963</idno><idno type="wicri:Area/Ncbi/Curation">002963</idno><idno type="wicri:Area/Ncbi/Checkpoint">002963</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment.</title><author><name sortKey="Duran, Raquel" sort="Duran, Raquel" uniqKey="Duran R" first="Raquel" last="Duran">Raquel Duran</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology and Institute of Neurosciences, Centro de Investigaciones Biomedicas (CIBM), University of Granada, Granada, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Physiology and Institute of Neurosciences, Centro de Investigaciones Biomedicas (CIBM), University of Granada, Granada</wicri:regionArea><orgName type="university">Université de Grenade</orgName><placeName><settlement type="city">Grenade (Espagne)</settlement><region nuts="2" type="region">Andalousie</region></placeName></affiliation></author><author><name sortKey="Barrero, Francisco J" sort="Barrero, Francisco J" uniqKey="Barrero F" first="Francisco J" last="Barrero">Francisco J. Barrero</name></author><author><name sortKey="Morales, Blas" sort="Morales, Blas" uniqKey="Morales B" first="Blas" last="Morales">Blas Morales</name></author><author><name sortKey="Luna, Juan D" sort="Luna, Juan D" uniqKey="Luna J" first="Juan D" last="Luna">Juan D. Luna</name></author><author><name sortKey="Ramirez, Manuel" sort="Ramirez, Manuel" uniqKey="Ramirez M" first="Manuel" last="Ramirez">Manuel Ramirez</name></author><author><name sortKey="Vives, Francisco" sort="Vives, Francisco" uniqKey="Vives F" first="Francisco" last="Vives">Francisco Vives</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Drug Therapy (statistics & numerical data)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>alpha-Synuclein (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Drug Therapy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alpha-synuclein (alpha-syn) is an intracellular protein with a high tendency to aggregation. It is the major component of Lewy bodies and may play a key role in the pathogenesis of Parkinson's disease (PD). alpha-Syn is also released by neurons and can be detected in biological fluids, such as plasma. The purpose of this study was to determine whether plasma alpha-syn concentrations are elevated in newly diagnosed PD patients before treatment (nontreated PD group, ntPD; n = 53) and to compare them with concentrations in PD patients with at least 1 year of specific treatment (tPD; n = 42) and in healthy controls (n = 60). Plasma alpha-syn concentrations in the ntPD and tPD groups were similar and significantly higher than in healthy controls. In conclusion, alpha-syn was elevated early in the development of PD and specific PD treatment did not change plasma alpha-syn levels.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Andalousie</li></region><settlement><li>Grenade (Espagne)</li></settlement><orgName><li>Université de Grenade</li></orgName></list><tree><noCountry><name sortKey="Barrero, Francisco J" sort="Barrero, Francisco J" uniqKey="Barrero F" first="Francisco J" last="Barrero">Francisco J. Barrero</name><name sortKey="Luna, Juan D" sort="Luna, Juan D" uniqKey="Luna J" first="Juan D" last="Luna">Juan D. Luna</name><name sortKey="Morales, Blas" sort="Morales, Blas" uniqKey="Morales B" first="Blas" last="Morales">Blas Morales</name><name sortKey="Ramirez, Manuel" sort="Ramirez, Manuel" uniqKey="Ramirez M" first="Manuel" last="Ramirez">Manuel Ramirez</name><name sortKey="Vives, Francisco" sort="Vives, Francisco" uniqKey="Vives F" first="Francisco" last="Vives">Francisco Vives</name></noCountry><country name="Espagne"><region name="Andalousie"><name sortKey="Duran, Raquel" sort="Duran, Raquel" uniqKey="Duran R" first="Raquel" last="Duran">Raquel Duran</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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