Myoclonus of peripheral origin: two case reports.
Identifieur interne : 002458 ( Ncbi/Checkpoint ); précédent : 002457; suivant : 002459Myoclonus of peripheral origin: two case reports.
Auteurs : Louise Tyvaert [France] ; Pierre Krystkowiak ; Francois Cassim ; Elise Houdayer ; Alexandre Kreisler ; Alain Destée [France] ; Luc Defebvre [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adolescent, Amputation Stumps (physiopathology), Anterior Horn Cells (physiology), Anti-Dyskinesia Agents (therapeutic use), Arm Injuries (surgery), Botulinum Toxins, Type A (therapeutic use), Brachial Plexus (injuries), Brachial Plexus (physiopathology), Cervical Vertebrae, Cicatrix (physiopathology), Elbow (injuries), Electromyography, Female, Humans, Lidocaine (therapeutic use), Male, Middle Aged, Myoclonus (drug therapy), Myoclonus (etiology), Neural Conduction, Paresthesia (etiology), Phantom Limb (complications), Physical Stimulation (adverse effects), Spinal Osteophytosis (complications), Ulnar Nerve (injuries), Ulnar Nerve (physiopathology).
- MESH :
- chemical , therapeutic use : Anti-Dyskinesia Agents, Botulinum Toxins, Type A, Lidocaine.
- adverse effects : Physical Stimulation.
- complications : Phantom Limb, Spinal Osteophytosis.
- drug therapy : Myoclonus.
- etiology : Myoclonus, Paresthesia.
- injuries : Brachial Plexus, Elbow, Ulnar Nerve.
- physiology : Anterior Horn Cells.
- physiopathology : Amputation Stumps, Brachial Plexus, Cicatrix, Ulnar Nerve.
- surgery : Arm Injuries.
- Adolescent, Cervical Vertebrae, Electromyography, Female, Humans, Male, Middle Aged, Neural Conduction.
Abstract
The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause-and-effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom-limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back-averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity.
DOI: 10.1002/mds.21998
PubMed: 19086086
Affiliations:
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Cassim</name></author><author><name sortKey="Houdayer, Elise" sort="Houdayer, Elise" uniqKey="Houdayer E" first="Elise" last="Houdayer">Elise Houdayer</name></author><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name><affiliation><country>France</country><placeName><settlement type="city">Lille</settlement><region type="region" nuts="2">Nord-Pas-de-Calais</region></placeName><orgName type="university" n="3">Université Lille 2</orgName><orgName type="institution" wicri:auto="newGroup">Université Lille Nord de France</orgName></affiliation></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><affiliation><country>France</country><placeName><settlement 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France</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Amputation Stumps (physiopathology)</term><term>Anterior Horn Cells (physiology)</term><term>Anti-Dyskinesia Agents (therapeutic use)</term><term>Arm Injuries (surgery)</term><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Brachial Plexus (injuries)</term><term>Brachial Plexus (physiopathology)</term><term>Cervical Vertebrae</term><term>Cicatrix (physiopathology)</term><term>Elbow (injuries)</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Lidocaine (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Myoclonus (drug therapy)</term><term>Myoclonus (etiology)</term><term>Neural Conduction</term><term>Paresthesia (etiology)</term><term>Phantom Limb (complications)</term><term>Physical Stimulation (adverse effects)</term><term>Spinal Osteophytosis (complications)</term><term>Ulnar Nerve (injuries)</term><term>Ulnar Nerve (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins, Type A</term><term>Lidocaine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Physical Stimulation</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Phantom Limb</term><term>Spinal Osteophytosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Myoclonus</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Myoclonus</term><term>Paresthesia</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Brachial Plexus</term><term>Elbow</term><term>Ulnar Nerve</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Anterior Horn Cells</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Amputation Stumps</term><term>Brachial Plexus</term><term>Cicatrix</term><term>Ulnar Nerve</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Arm Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Cervical Vertebrae</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neural Conduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause-and-effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom-limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back-averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement><orgName><li>Université Lille 2</li><li>Université Lille Nord de France</li></orgName></list><tree><noCountry><name sortKey="Cassim, Francois" sort="Cassim, Francois" uniqKey="Cassim F" first="Francois" last="Cassim">Francois Cassim</name><name sortKey="Houdayer, Elise" sort="Houdayer, Elise" uniqKey="Houdayer E" first="Elise" last="Houdayer">Elise Houdayer</name><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name><name sortKey="Krystkowiak, Pierre" sort="Krystkowiak, Pierre" uniqKey="Krystkowiak P" first="Pierre" last="Krystkowiak">Pierre Krystkowiak</name></noCountry><country name="France"><noRegion><name sortKey="Tyvaert, Louise" sort="Tyvaert, Louise" uniqKey="Tyvaert L" first="Louise" last="Tyvaert">Louise Tyvaert</name></noRegion><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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