Myoclonus of peripheral origin: two case reports.
Identifieur interne : 001F07 ( PubMed/Corpus ); précédent : 001F06; suivant : 001F08Myoclonus of peripheral origin: two case reports.
Auteurs : Louise Tyvaert ; Pierre Krystkowiak ; Francois Cassim ; Elise Houdayer ; Alexandre Kreisler ; Alain Destée ; Luc DefebvreSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adolescent, Amputation Stumps (physiopathology), Anterior Horn Cells (physiology), Anti-Dyskinesia Agents (therapeutic use), Arm Injuries (surgery), Botulinum Toxins, Type A (therapeutic use), Brachial Plexus (injuries), Brachial Plexus (physiopathology), Cervical Vertebrae, Cicatrix (physiopathology), Elbow (injuries), Electromyography, Female, Humans, Lidocaine (therapeutic use), Male, Middle Aged, Myoclonus (drug therapy), Myoclonus (etiology), Neural Conduction, Paresthesia (etiology), Phantom Limb (complications), Physical Stimulation (adverse effects), Spinal Osteophytosis (complications), Ulnar Nerve (injuries), Ulnar Nerve (physiopathology).
- MESH :
- chemical , therapeutic use : Anti-Dyskinesia Agents, Botulinum Toxins, Type A, Lidocaine.
- adverse effects : Physical Stimulation.
- complications : Phantom Limb, Spinal Osteophytosis.
- drug therapy : Myoclonus.
- etiology : Myoclonus, Paresthesia.
- injuries : Brachial Plexus, Elbow, Ulnar Nerve.
- physiology : Anterior Horn Cells.
- physiopathology : Amputation Stumps, Brachial Plexus, Cicatrix, Ulnar Nerve.
- surgery : Arm Injuries.
- Adolescent, Cervical Vertebrae, Electromyography, Female, Humans, Male, Middle Aged, Neural Conduction.
Abstract
The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause-and-effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom-limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back-averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity.
DOI: 10.1002/mds.21998
PubMed: 19086086
Links to Exploration step
pubmed:19086086Le document en format XML
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last="Kreisler">Alexandre Kreisler</name></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1002/mds.21998</idno><idno type="RBID">pubmed:19086086</idno><idno type="pmid">19086086</idno><idno type="wicri:Area/PubMed/Corpus">001F07</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Myoclonus of peripheral origin: two case reports.</title><author><name sortKey="Tyvaert, Louise" sort="Tyvaert, Louise" uniqKey="Tyvaert L" first="Louise" last="Tyvaert">Louise Tyvaert</name><affiliation><nlm:affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Krystkowiak, Pierre" sort="Krystkowiak, Pierre" uniqKey="Krystkowiak P" first="Pierre" last="Krystkowiak">Pierre Krystkowiak</name></author><author><name sortKey="Cassim, Francois" sort="Cassim, Francois" uniqKey="Cassim F" first="Francois" last="Cassim">Francois Cassim</name></author><author><name sortKey="Houdayer, Elise" sort="Houdayer, Elise" uniqKey="Houdayer E" first="Elise" last="Houdayer">Elise Houdayer</name></author><author><name sortKey="Kreisler, Alexandre" sort="Kreisler, Alexandre" uniqKey="Kreisler A" first="Alexandre" last="Kreisler">Alexandre Kreisler</name></author><author><name sortKey="Destee, Alain" sort="Destee, Alain" uniqKey="Destee A" first="Alain" last="Destée">Alain Destée</name></author><author><name sortKey="Defebvre, Luc" sort="Defebvre, Luc" uniqKey="Defebvre L" first="Luc" last="Defebvre">Luc Defebvre</name></author></analytic><series><title level="j">Movement disorders : official 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Limb (complications)</term><term>Physical Stimulation (adverse effects)</term><term>Spinal Osteophytosis (complications)</term><term>Ulnar Nerve (injuries)</term><term>Ulnar Nerve (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Dyskinesia Agents</term><term>Botulinum Toxins, Type A</term><term>Lidocaine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Physical Stimulation</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Phantom Limb</term><term>Spinal Osteophytosis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Myoclonus</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Myoclonus</term><term>Paresthesia</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Brachial Plexus</term><term>Elbow</term><term>Ulnar Nerve</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Anterior Horn Cells</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Amputation Stumps</term><term>Brachial Plexus</term><term>Cicatrix</term><term>Ulnar Nerve</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Arm Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Cervical Vertebrae</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neural Conduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause-and-effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom-limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back-averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19086086</PMID><DateCreated><Year>2009</Year><Month>02</Month><Day>02</Day></DateCreated><DateCompleted><Year>2009</Year><Month>06</Month><Day>08</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>2</Issue><PubDate><Year>2009</Year><Month>Jan</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Myoclonus of peripheral origin: two case reports.</ArticleTitle><Pagination><MedlinePgn>274-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.21998</ELocationID><Abstract><AbstractText>The concept of peripheral myoclonus is not yet fully accepted by the medical community because of the difficulty in establishing a cause-and-effect relationship between trauma and subsequent movement disorders. Here, we report two cases of patients suffering from peripheral myoclonus after nerve injury. The first patient experienced myoclonus of the 4th dorsal interosseous muscle several days after trauma to the elbow. The second patient presented myoclonus of the arm stump (combined with phantom-limb pain) 1 year after amputation. In both cases, central nervous system function (spine and brain imaging, somesthetic evoked potentials, EEG back-averaging) was normal. For the second patient, local infiltration of xylocaine and botulinum toxin into the stump scar rapidly stopped myoclonus and pain. Nerve injury induces ephaptic transmission and ectopic excitation. The physiopathological mechanisms of this type of myoclonus involve a peripheral generator that induces central (spinal) generator activity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tyvaert</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Neurology and Movement Disorders, Lille University Hospital, Lille Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krystkowiak</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Cassim</LastName><ForeName>Francois</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Houdayer</LastName><ForeName>Elise</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Kreisler</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Destée</LastName><ForeName>Alain</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Defebvre</LastName><ForeName>Luc</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018726">Anti-Dyskinesia Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>98PI200987</RegistryNumber><NameOfSubstance UI="D008012">Lidocaine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.24.69</RegistryNumber><NameOfSubstance UI="D019274">Botulinum Toxins, Type A</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000672">Amputation Stumps</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000870">Anterior Horn Cells</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018726">Anti-Dyskinesia Agents</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001134">Arm Injuries</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019274">Botulinum Toxins, Type A</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001917">Brachial Plexus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000293">injuries</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002574">Cervical Vertebrae</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002921">Cicatrix</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004550">Elbow</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000293">injuries</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008012">Lidocaine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009207">Myoclonus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009431">Neural Conduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010292">Paresthesia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010591">Phantom Limb</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010812">Physical Stimulation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013128">Spinal Osteophytosis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014459">Ulnar Nerve</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000293">injuries</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>12</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>12</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>6</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21998</ArticleId><ArticleId IdType="pubmed">19086086</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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