The prodromal phase of sporadic Parkinson's disease: does it exist and if so how long is it?
Identifieur interne : 002294 ( Ncbi/Checkpoint ); précédent : 002293; suivant : 002295The prodromal phase of sporadic Parkinson's disease: does it exist and if so how long is it?
Auteurs : Christopher H. Hawkes [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Humans, Olfaction Disorders (complications), Olfaction Disorders (pathology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Primary Dysautonomias (complications), Primary Dysautonomias (pathology), Risk Factors, Severity of Illness Index, Sleep Disorders (complications), Sleep Disorders (pathology).
- MESH :
- complications : Olfaction Disorders, Parkinson Disease, Primary Dysautonomias, Sleep Disorders.
- diagnosis : Parkinson Disease.
- pathology : Olfaction Disorders, Primary Dysautonomias, Sleep Disorders.
- Humans, Risk Factors, Severity of Illness Index.
Abstract
It is frequently assumed that idiopathic Parkinson's disease starts with several nonmotor symptoms and signs, but the evidence for this stage in the disease process is of variable quality. This review evaluates the more robust prospective or pathologically confirmed publications to establish whether there is a premotor period and if so what is its duration. The most informative studies are considered to be those concerned with olfaction, dysautonomia, and sleep disorder. Estimates for the duration of the prodromal phase vary from months to decades. It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established.
DOI: 10.1002/mds.22242
PubMed: 18759359
Affiliations:
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pubmed:18759359Le document en format XML
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Hawkes</name><affiliation wicri:level="3"><nlm:affiliation>Neuroscience Centre, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, United Kingdom. chrishawkes@msn.com</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Neuroscience Centre, Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Olfaction Disorders (complications)</term><term>Olfaction Disorders (pathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Primary Dysautonomias (complications)</term><term>Primary Dysautonomias (pathology)</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Sleep Disorders (complications)</term><term>Sleep Disorders (pathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Olfaction Disorders</term><term>Parkinson Disease</term><term>Primary Dysautonomias</term><term>Sleep Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Olfaction Disorders</term><term>Primary Dysautonomias</term><term>Sleep Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Risk Factors</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is frequently assumed that idiopathic Parkinson's disease starts with several nonmotor symptoms and signs, but the evidence for this stage in the disease process is of variable quality. This review evaluates the more robust prospective or pathologically confirmed publications to establish whether there is a premotor period and if so what is its duration. The most informative studies are considered to be those concerned with olfaction, dysautonomia, and sleep disorder. Estimates for the duration of the prodromal phase vary from months to decades. It is concluded that there probably is an early phase in the disease where a variety of nonmotor features develop, but the sequence and time of onset of such features is not well established.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hawkes, Christopher H" sort="Hawkes, Christopher H" uniqKey="Hawkes C" first="Christopher H" last="Hawkes">Christopher H. 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