Reversal of head drop after discontinuation of olanzapine in a DLB patient.
Identifieur interne : 002226 ( Ncbi/Checkpoint ); précédent : 002225; suivant : 002227Reversal of head drop after discontinuation of olanzapine in a DLB patient.
Auteurs : Marcel J H. Aries [Belgique] ; Hans Debruyne ; Sebastiaan Engelborghs ; Nathalie Le Bastard ; Nore Somers ; Dagmar Gorissen ; Barbara A. Pickut ; Peter Paul De DeynSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Antipsychotic Agents (adverse effects), Benzodiazepines (adverse effects), Dopamine Antagonists (therapeutic use), Female, Hallucinations (complications), Hallucinations (drug therapy), Head Movements (drug effects), Humans, Kyphosis (drug therapy), Kyphosis (etiology), Lewy Body Disease (complications), Lewy Body Disease (drug therapy), Muscular Diseases (drug therapy), Muscular Diseases (etiology).
- MESH :
- chemical , adverse effects : Antipsychotic Agents, Benzodiazepines.
- chemical , therapeutic use : Dopamine Antagonists.
- complications : Hallucinations, Lewy Body Disease.
- drug effects : Head Movements.
- drug therapy : Hallucinations, Kyphosis, Lewy Body Disease, Muscular Diseases.
- etiology : Kyphosis, Muscular Diseases.
- Aged, Female, Humans.
Abstract
We present a 72-year-oldpatient with probable diffuse Lewy body disease and visual hallucinations, who developed subacute reversible "dropped head syndrome" and parkinsonian signs after the introduction of olanzapine at a total daily dose of 10 mg. One week after olanzapine was withdrawn, the patient's posture started to improve. Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade.
DOI: 10.1002/mds.22182
PubMed: 18661562
Affiliations:
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Aries</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Memory Clinic, ZNA-Middelheim and ZNA-Hoge Beuken, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology and Memory Clinic, ZNA-Middelheim and ZNA-Hoge Beuken, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Debruyne, Hans" sort="Debruyne, Hans" uniqKey="Debruyne H" first="Hans" last="Debruyne">Hans Debruyne</name></author><author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name></author><author><name sortKey="Le Bastard, Nathalie" sort="Le Bastard, Nathalie" uniqKey="Le Bastard N" first="Nathalie" last="Le Bastard">Nathalie Le Bastard</name></author><author><name sortKey="Somers, Nore" sort="Somers, Nore" uniqKey="Somers N" first="Nore" last="Somers">Nore Somers</name></author><author><name sortKey="Gorissen, Dagmar" sort="Gorissen, Dagmar" uniqKey="Gorissen D" first="Dagmar" last="Gorissen">Dagmar Gorissen</name></author><author><name sortKey="Pickut, Barbara A" sort="Pickut, Barbara A" uniqKey="Pickut B" first="Barbara A" last="Pickut">Barbara A. Pickut</name></author><author><name sortKey="De Deyn, Peter Paul" sort="De Deyn, Peter Paul" uniqKey="De Deyn P" first="Peter Paul" last="De Deyn">Peter Paul De Deyn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.22182</idno><idno type="RBID">pubmed:18661562</idno><idno type="pmid">18661562</idno><idno type="wicri:Area/PubMed/Corpus">002137</idno><idno type="wicri:Area/PubMed/Curation">002137</idno><idno type="wicri:Area/PubMed/Checkpoint">002100</idno><idno type="wicri:Area/Ncbi/Merge">002226</idno><idno type="wicri:Area/Ncbi/Curation">002226</idno><idno type="wicri:Area/Ncbi/Checkpoint">002226</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reversal of head drop after discontinuation of olanzapine in a DLB patient.</title><author><name sortKey="Aries, Marcel J H" sort="Aries, Marcel J H" uniqKey="Aries M" first="Marcel J H" last="Aries">Marcel J H. Aries</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Memory Clinic, ZNA-Middelheim and ZNA-Hoge Beuken, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Neurology and Memory Clinic, ZNA-Middelheim and ZNA-Hoge Beuken, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author><author><name sortKey="Debruyne, Hans" sort="Debruyne, Hans" uniqKey="Debruyne H" first="Hans" last="Debruyne">Hans Debruyne</name></author><author><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name></author><author><name sortKey="Le Bastard, Nathalie" sort="Le Bastard, Nathalie" uniqKey="Le Bastard N" first="Nathalie" last="Le Bastard">Nathalie Le Bastard</name></author><author><name sortKey="Somers, Nore" sort="Somers, Nore" uniqKey="Somers N" first="Nore" last="Somers">Nore Somers</name></author><author><name sortKey="Gorissen, Dagmar" sort="Gorissen, Dagmar" uniqKey="Gorissen D" first="Dagmar" last="Gorissen">Dagmar Gorissen</name></author><author><name sortKey="Pickut, Barbara A" sort="Pickut, Barbara A" uniqKey="Pickut B" first="Barbara A" last="Pickut">Barbara A. Pickut</name></author><author><name sortKey="De Deyn, Peter Paul" sort="De Deyn, Peter Paul" uniqKey="De Deyn P" first="Peter Paul" last="De Deyn">Peter Paul De Deyn</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antipsychotic Agents (adverse effects)</term><term>Benzodiazepines (adverse effects)</term><term>Dopamine Antagonists (therapeutic use)</term><term>Female</term><term>Hallucinations (complications)</term><term>Hallucinations (drug therapy)</term><term>Head Movements (drug effects)</term><term>Humans</term><term>Kyphosis (drug therapy)</term><term>Kyphosis (etiology)</term><term>Lewy Body Disease (complications)</term><term>Lewy Body Disease (drug therapy)</term><term>Muscular Diseases (drug therapy)</term><term>Muscular Diseases (etiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antipsychotic Agents</term><term>Benzodiazepines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Antagonists</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Hallucinations</term><term>Lewy Body Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Head Movements</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hallucinations</term><term>Kyphosis</term><term>Lewy Body Disease</term><term>Muscular Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Kyphosis</term><term>Muscular Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We present a 72-year-oldpatient with probable diffuse Lewy body disease and visual hallucinations, who developed subacute reversible "dropped head syndrome" and parkinsonian signs after the introduction of olanzapine at a total daily dose of 10 mg. One week after olanzapine was withdrawn, the patient's posture started to improve. Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade.</div></front></TEI><affiliations><list><country><li>Belgique</li></country></list><tree><noCountry><name sortKey="De Deyn, Peter Paul" sort="De Deyn, Peter Paul" uniqKey="De Deyn P" first="Peter Paul" last="De Deyn">Peter Paul De Deyn</name><name sortKey="Debruyne, Hans" sort="Debruyne, Hans" uniqKey="Debruyne H" first="Hans" last="Debruyne">Hans Debruyne</name><name sortKey="Engelborghs, Sebastiaan" sort="Engelborghs, Sebastiaan" uniqKey="Engelborghs S" first="Sebastiaan" last="Engelborghs">Sebastiaan Engelborghs</name><name sortKey="Gorissen, Dagmar" sort="Gorissen, Dagmar" uniqKey="Gorissen D" first="Dagmar" last="Gorissen">Dagmar Gorissen</name><name sortKey="Le Bastard, Nathalie" sort="Le Bastard, Nathalie" uniqKey="Le Bastard N" first="Nathalie" last="Le Bastard">Nathalie Le Bastard</name><name sortKey="Pickut, Barbara A" sort="Pickut, Barbara A" uniqKey="Pickut B" first="Barbara A" last="Pickut">Barbara A. Pickut</name><name sortKey="Somers, Nore" sort="Somers, Nore" uniqKey="Somers N" first="Nore" last="Somers">Nore Somers</name></noCountry><country name="Belgique"><noRegion><name sortKey="Aries, Marcel J H" sort="Aries, Marcel J H" uniqKey="Aries M" first="Marcel J H" last="Aries">Marcel J H. Aries</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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