Reversal of head drop after discontinuation of olanzapine in a DLB patient.
Identifieur interne : 002137 ( PubMed/Curation ); précédent : 002136; suivant : 002138Reversal of head drop after discontinuation of olanzapine in a DLB patient.
Auteurs : Marcel J H. Aries [Belgique] ; Hans Debruyne ; Sebastiaan Engelborghs ; Nathalie Le Bastard ; Nore Somers ; Dagmar Gorissen ; Barbara A. Pickut ; Peter Paul De DeynSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Antipsychotic Agents (adverse effects), Benzodiazepines (adverse effects), Dopamine Antagonists (therapeutic use), Female, Hallucinations (complications), Hallucinations (drug therapy), Head Movements (drug effects), Humans, Kyphosis (drug therapy), Kyphosis (etiology), Lewy Body Disease (complications), Lewy Body Disease (drug therapy), Muscular Diseases (drug therapy), Muscular Diseases (etiology).
- MESH :
- chemical , adverse effects : Antipsychotic Agents, Benzodiazepines.
- chemical , therapeutic use : Dopamine Antagonists.
- complications : Hallucinations, Lewy Body Disease.
- drug effects : Head Movements.
- drug therapy : Hallucinations, Kyphosis, Lewy Body Disease, Muscular Diseases.
- etiology : Kyphosis, Muscular Diseases.
- Aged, Female, Humans.
Abstract
We present a 72-year-oldpatient with probable diffuse Lewy body disease and visual hallucinations, who developed subacute reversible "dropped head syndrome" and parkinsonian signs after the introduction of olanzapine at a total daily dose of 10 mg. One week after olanzapine was withdrawn, the patient's posture started to improve. Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade.
DOI: 10.1002/mds.22182
PubMed: 18661562
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pubmed:18661562Le document en format XML
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<front><div type="abstract" xml:lang="en">We present a 72-year-oldpatient with probable diffuse Lewy body disease and visual hallucinations, who developed subacute reversible "dropped head syndrome" and parkinsonian signs after the introduction of olanzapine at a total daily dose of 10 mg. One week after olanzapine was withdrawn, the patient's posture started to improve. Further improvement was achieved after dopaminergic substitution. Clinical and electrophysiological observations might indicate neck extensor myopathy due to axial rigidity or focal neck dystonia, induced by dopamine receptor blockade.</div>
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