Mirror movements in patients with Parkinson's disease.
Identifieur interne : 001F20 ( Ncbi/Checkpoint ); précédent : 001F19; suivant : 001F21Mirror movements in patients with Parkinson's disease.
Auteurs : Donatella Ottaviani [Italie] ; Dorina Tiple ; Antonio Suppa ; Carlo Colosimo ; Giovanni Fabbrini ; Massimo Cincotta ; Giovanni Defazio ; Alfredo BerardelliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- methods : Electromyography.
- physiology : Functional Laterality, Movement.
- physiopathology : Hand, Parkinson Disease.
- Aged, Analysis of Variance, Case-Control Studies, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Mirror movements (MM) refer to ipsilateral involuntary movements that appear during voluntary activity in contralateral homologous body regions. This study aimed to compare the frequency and distribution of MM in an unselected sample of 274 patients with Parkinson's disease (PD) and 100 healthy subjects, and to check a possible relationship between MM and parkinsonian features. MM of the hand were scored according to the Woods and Teuber scale. The frequency of MM was lower in PD patients than in healthy subjects (29% vs. 71%, P < 0.0001). The distribution of MM also differed in the two groups being often bilateral in healthy subjects, invariably unilateral in PD patients. When parkinsonian signs were unilateral, MM always manifested on the unaffected side; when parkinsonian signs were bilateral, MM manifested on the less affected side. PD patients manifesting MM scored significantly lower on Hohen and Yahr staging than patients without MM. Likewise, there was a significant inverse correlation between the intensity of MM as rated by the Woods and Teuber score and HY staging (r = -0.16, P < 0.01). The low frequency of MM in PD probably relates to the complex interactions between the pathophysiological mechanisms leading to parkinsonian signs and the mechanisms responsible for movement lateralization.
DOI: 10.1002/mds.21825
PubMed: 17999432
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mirror movements in patients with Parkinson's disease.</title><author><name sortKey="Ottaviani, Donatella" sort="Ottaviani, Donatella" uniqKey="Ottaviani D" first="Donatella" last="Ottaviani">Donatella Ottaviani</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurological Sciences and Neuromed Institute (IRCCS), La Sapienza University of Rome, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences and Neuromed Institute (IRCCS), La Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tiple, Dorina" sort="Tiple, Dorina" uniqKey="Tiple D" first="Dorina" last="Tiple">Dorina Tiple</name></author><author><name sortKey="Suppa, Antonio" sort="Suppa, Antonio" uniqKey="Suppa A" first="Antonio" last="Suppa">Antonio Suppa</name></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name></author><author><name sortKey="Cincotta, Massimo" sort="Cincotta, Massimo" uniqKey="Cincotta M" first="Massimo" last="Cincotta">Massimo Cincotta</name></author><author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21825</idno><idno type="RBID">pubmed:17999432</idno><idno 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Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Tiple, Dorina" sort="Tiple, Dorina" uniqKey="Tiple D" first="Dorina" last="Tiple">Dorina Tiple</name></author><author><name sortKey="Suppa, Antonio" sort="Suppa, Antonio" uniqKey="Suppa A" first="Antonio" last="Suppa">Antonio Suppa</name></author><author><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name></author><author><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name></author><author><name sortKey="Cincotta, Massimo" sort="Cincotta, Massimo" uniqKey="Cincotta M" first="Massimo" last="Cincotta">Massimo Cincotta</name></author><author><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Electromyography (methods)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Hand (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Movement</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hand</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mirror movements (MM) refer to ipsilateral involuntary movements that appear during voluntary activity in contralateral homologous body regions. This study aimed to compare the frequency and distribution of MM in an unselected sample of 274 patients with Parkinson's disease (PD) and 100 healthy subjects, and to check a possible relationship between MM and parkinsonian features. MM of the hand were scored according to the Woods and Teuber scale. The frequency of MM was lower in PD patients than in healthy subjects (29% vs. 71%, P < 0.0001). The distribution of MM also differed in the two groups being often bilateral in healthy subjects, invariably unilateral in PD patients. When parkinsonian signs were unilateral, MM always manifested on the unaffected side; when parkinsonian signs were bilateral, MM manifested on the less affected side. PD patients manifesting MM scored significantly lower on Hohen and Yahr staging than patients without MM. Likewise, there was a significant inverse correlation between the intensity of MM as rated by the Woods and Teuber score and HY staging (r = -0.16, P < 0.01). The low frequency of MM in PD probably relates to the complex interactions between the pathophysiological mechanisms leading to parkinsonian signs and the mechanisms responsible for movement lateralization.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Cincotta, Massimo" sort="Cincotta, Massimo" uniqKey="Cincotta M" first="Massimo" last="Cincotta">Massimo Cincotta</name><name sortKey="Colosimo, Carlo" sort="Colosimo, Carlo" uniqKey="Colosimo C" first="Carlo" last="Colosimo">Carlo Colosimo</name><name sortKey="Defazio, Giovanni" sort="Defazio, Giovanni" uniqKey="Defazio G" first="Giovanni" last="Defazio">Giovanni Defazio</name><name sortKey="Fabbrini, Giovanni" sort="Fabbrini, Giovanni" uniqKey="Fabbrini G" first="Giovanni" last="Fabbrini">Giovanni Fabbrini</name><name sortKey="Suppa, Antonio" sort="Suppa, Antonio" uniqKey="Suppa A" first="Antonio" last="Suppa">Antonio Suppa</name><name sortKey="Tiple, Dorina" sort="Tiple, Dorina" uniqKey="Tiple D" first="Dorina" last="Tiple">Dorina Tiple</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Ottaviani, Donatella" sort="Ottaviani, Donatella" uniqKey="Ottaviani D" first="Donatella" last="Ottaviani">Donatella Ottaviani</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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