Population-based case-control study of cigarette smoking and essential tremor.
Identifieur interne : 001F19 ( Ncbi/Checkpoint ); précédent : 001F18; suivant : 001F20Population-based case-control study of cigarette smoking and essential tremor.
Auteurs : Julián Benito-Le N [Espagne] ; Elan D. Louis ; Félix Bermejo-ParejaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- complications : Essential Tremor.
- epidemiology : Essential Tremor.
- Aged, Aged, 80 and over, Case-Control Studies, Community Health Planning, Female, Humans, Male, Odds Ratio, Questionnaires, Regression Analysis, Smoking.
Abstract
Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long-standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population-based, case-control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 +/- 7.1 years old) and 663 matched controls (74.6 +/- 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55-1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink-years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40-0.84, P = 0.004). There was a strong inverse association between pack-years and odds of ET (adjusted OR 0.991, 95% CI 0.984-0.997, P = 0.005, i.e., with every 10 pack-year increase, odds of ET were lowered 10%). Ever smokers in the highest pack-year tertile were one-third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22-0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect.
DOI: 10.1002/mds.21810
PubMed: 17999431
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Population-based case-control study of cigarette smoking and essential tremor.</title><author><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain. jbenitol@meditex.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Hospital 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1002/mds.21810</idno><idno type="RBID">pubmed:17999431</idno><idno type="pmid">17999431</idno><idno type="wicri:Area/PubMed/Corpus">002440</idno><idno type="wicri:Area/PubMed/Curation">002440</idno><idno type="wicri:Area/PubMed/Checkpoint">002137</idno><idno type="wicri:Area/Ncbi/Merge">001F19</idno><idno type="wicri:Area/Ncbi/Curation">001F19</idno><idno type="wicri:Area/Ncbi/Checkpoint">001F19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Population-based case-control study of cigarette smoking and essential tremor.</title><author><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Hospital 12 de Octubre, Madrid, Spain. jbenitol@meditex.es</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Neurology, University Hospital 12 de Octubre, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></author><author><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Community Health Planning</term><term>Essential Tremor (complications)</term><term>Essential Tremor (epidemiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Odds Ratio</term><term>Questionnaires</term><term>Regression Analysis</term><term>Smoking</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Essential Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Community Health Planning</term><term>Female</term><term>Humans</term><term>Male</term><term>Odds Ratio</term><term>Questionnaires</term><term>Regression Analysis</term><term>Smoking</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is inversely associated with smoking cigarettes. Despite long-standing clinical links between PD and essential tremor (ET), there are surprisingly few data on smoking in ET. We studied whether smoking cigarettes is inversely associated with ET. Using a population-based, case-control design, cigarette smoking habits were assessed in 221 prevalent ET cases (75.5 +/- 7.1 years old) and 663 matched controls (74.6 +/- 7.0 years old). In logistical regression analyses, diagnosis (ET vs. control) was the dependent variable, and cigarette smoking status, the independent variable. Ever smokers were marginally less likely to have ET than were never smokers (22.0% vs. 27.0%, odds ratio [OR] 0.76, 95% confidence interval [CI] 0.55-1.04, P = 0.09). In an analysis that adjusted for confounding factors (drink-years and depressive symptoms), ever smokers were nearly half less likely to have ET than the never smokers (OR 0.58, 95% CI 0.40-0.84, P = 0.004). There was a strong inverse association between pack-years and odds of ET (adjusted OR 0.991, 95% CI 0.984-0.997, P = 0.005, i.e., with every 10 pack-year increase, odds of ET were lowered 10%). Ever smokers in the highest pack-year tertile were one-third as likely to have ET than the never smokers (adjusted OR 0.39, 95% CI 0.22-0.69, P = 0.001). We demonstrated an inverse association between ever smoking and ET. Additional studies are needed to reproduce these findings and assess whether this association is due to a biologically protective effect.</div></front></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Communauté de Madrid</li></region><settlement><li>Madrid</li></settlement></list><tree><noCountry><name sortKey="Bermejo Pareja, Felix" sort="Bermejo Pareja, Felix" uniqKey="Bermejo Pareja F" first="Félix" last="Bermejo-Pareja">Félix Bermejo-Pareja</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D" last="Louis">Elan D. Louis</name></noCountry><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Benito Le N, Julian" sort="Benito Le N, Julian" uniqKey="Benito Le N J" first="Julián" last="Benito-Le N">Julián Benito-Le N</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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