Manganic encephalopathy due to "ephedrone" abuse.
Identifieur interne : 001D02 ( Ncbi/Checkpoint ); précédent : 001D01; suivant : 001D03Manganic encephalopathy due to "ephedrone" abuse.
Auteurs : Yanush Sanotsky [Ukraine] ; Roman Lesyk ; Lyudmyla Fedoryshyn ; Iryna Komnatska ; Yuriy Matviyenko ; Stanley FahnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Basal Ganglia (pathology), Brain Diseases (etiology), Brain Diseases (pathology), Humans, Magnetic Resonance Imaging, Male, Manganese Poisoning (complications), Middle Aged, Propiophenones (adverse effects), Retrospective Studies, Substance-Related Disorders (complications), Substance-Related Disorders (etiology).
- MESH :
- chemical , adverse effects : Propiophenones.
- complications : Manganese Poisoning, Substance-Related Disorders.
- etiology : Brain Diseases, Substance-Related Disorders.
- pathology : Basal Ganglia, Brain Diseases.
- Adult, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies.
Abstract
We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.
DOI: 10.1002/mds.21378
PubMed: 17566121
Affiliations:
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The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.</div></front></TEI><affiliations><list><country><li>Ukraine</li></country></list><tree><noCountry><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name></noCountry><country name="Ukraine"><noRegion><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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