Manganic encephalopathy due to "ephedrone" abuse.
Identifieur interne : 002637 ( PubMed/Curation ); précédent : 002636; suivant : 002638Manganic encephalopathy due to "ephedrone" abuse.
Auteurs : Yanush Sanotsky [Ukraine] ; Roman Lesyk ; Lyudmyla Fedoryshyn ; Iryna Komnatska ; Yuriy Matviyenko ; Stanley FahnSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Basal Ganglia (pathology), Brain Diseases (etiology), Brain Diseases (pathology), Humans, Magnetic Resonance Imaging, Male, Manganese Poisoning (complications), Middle Aged, Propiophenones (adverse effects), Retrospective Studies, Substance-Related Disorders (complications), Substance-Related Disorders (etiology).
- MESH :
- chemical , adverse effects : Propiophenones.
- complications : Manganese Poisoning, Substance-Related Disorders.
- etiology : Brain Diseases, Substance-Related Disorders.
- pathology : Basal Ganglia, Brain Diseases.
- Adult, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies.
Abstract
We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.
DOI: 10.1002/mds.21378
PubMed: 17566121
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002637
Links to Exploration step
pubmed:17566121Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Manganic encephalopathy due to "ephedrone" abuse.</title>
<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lviv Regional Clinical Hospital, Lviv, Ukraine. janush_s@yahoo.com</nlm:affiliation>
<country xml:lang="fr">Ukraine</country>
<wicri:regionArea>Department of Neurology, Lviv Regional Clinical Hospital, Lviv</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
</author>
<author><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
</author>
<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
</author>
<author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2007">2007</date>
<idno type="doi">10.1002/mds.21378</idno>
<idno type="RBID">pubmed:17566121</idno>
<idno type="pmid">17566121</idno>
<idno type="wicri:Area/PubMed/Corpus">002637</idno>
<idno type="wicri:Area/PubMed/Curation">002637</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Manganic encephalopathy due to "ephedrone" abuse.</title>
<author><name sortKey="Sanotsky, Yanush" sort="Sanotsky, Yanush" uniqKey="Sanotsky Y" first="Yanush" last="Sanotsky">Yanush Sanotsky</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Lviv Regional Clinical Hospital, Lviv, Ukraine. janush_s@yahoo.com</nlm:affiliation>
<country xml:lang="fr">Ukraine</country>
<wicri:regionArea>Department of Neurology, Lviv Regional Clinical Hospital, Lviv</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lesyk, Roman" sort="Lesyk, Roman" uniqKey="Lesyk R" first="Roman" last="Lesyk">Roman Lesyk</name>
</author>
<author><name sortKey="Fedoryshyn, Lyudmyla" sort="Fedoryshyn, Lyudmyla" uniqKey="Fedoryshyn L" first="Lyudmyla" last="Fedoryshyn">Lyudmyla Fedoryshyn</name>
</author>
<author><name sortKey="Komnatska, Iryna" sort="Komnatska, Iryna" uniqKey="Komnatska I" first="Iryna" last="Komnatska">Iryna Komnatska</name>
</author>
<author><name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
</author>
<author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2007" type="published">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Basal Ganglia (pathology)</term>
<term>Brain Diseases (etiology)</term>
<term>Brain Diseases (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Manganese Poisoning (complications)</term>
<term>Middle Aged</term>
<term>Propiophenones (adverse effects)</term>
<term>Retrospective Studies</term>
<term>Substance-Related Disorders (complications)</term>
<term>Substance-Related Disorders (etiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Propiophenones</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Manganese Poisoning</term>
<term>Substance-Related Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Diseases</term>
<term>Substance-Related Disorders</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Brain Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17566121</PMID>
<DateCreated><Year>2007</Year>
<Month>07</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted><Year>2008</Year>
<Month>04</Month>
<Day>16</Day>
</DateCompleted>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<Issue>9</Issue>
<PubDate><Year>2007</Year>
<Month>Jul</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Manganic encephalopathy due to "ephedrone" abuse.</ArticleTitle>
<Pagination><MedlinePgn>1337-43</MedlinePgn>
</Pagination>
<Abstract><AbstractText>We describe the clinical and neuroimaging features of 6 drug-abuse patients with self-inflicted manganese poisoning. The patients injected a home-brewed mixture called "ephedrone" (slang term) that contained manganese to produce an amphetamine-like euphoria. The desired chemical product, phenylpropanoneamine (also called methcathinone), was synthesized from a common-cold-remedy compound using permanganate as the catalyst. Manganese was a by-product in the ephedrone mixture. After months of self-injections, a clinical picture emerged, consisting of apathy, bradykinesia, gait disorder with postural instability, and spastic-hypokinetic dysarthria. There was no response to levodopa. The MRI revealed symmetric hyperintense T1-weighted signals in the basal ganglia, typical of manganese accumulation.</AbstractText>
<CopyrightInformation>2007 Movement Disorder Society</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sanotsky</LastName>
<ForeName>Yanush</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Lviv Regional Clinical Hospital, Lviv, Ukraine. janush_s@yahoo.com</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lesyk</LastName>
<ForeName>Roman</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fedoryshyn</LastName>
<ForeName>Lyudmyla</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Komnatska</LastName>
<ForeName>Iryna</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Matviyenko</LastName>
<ForeName>Yuriy</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fahn</LastName>
<ForeName>Stanley</ForeName>
<Initials>S</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011427">Propiophenones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>5650-44-2</RegistryNumber>
<NameOfSubstance UI="C047806">monomethylpropion</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001479">Basal Ganglia</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D001927">Brain Diseases</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020149">Manganese Poisoning</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D011427">Propiophenones</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000009">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D012189">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D019966">Substance-Related Disorders</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000150">complications</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000209">etiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year>
<Month>6</Month>
<Day>15</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2008</Year>
<Month>4</Month>
<Day>17</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2007</Year>
<Month>6</Month>
<Day>15</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="doi">10.1002/mds.21378</ArticleId>
<ArticleId IdType="pubmed">17566121</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002637 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 002637 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:17566121 |texte= Manganic encephalopathy due to "ephedrone" abuse. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:17566121" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |