Bowel movement frequency in late-life and incidental Lewy bodies.
Identifieur interne : 001C48 ( Ncbi/Checkpoint ); précédent : 001C47; suivant : 001C49Bowel movement frequency in late-life and incidental Lewy bodies.
Auteurs : Robert D. Abbott [États-Unis] ; G Webster Ross ; Helen Petrovitch ; Caroline M. Tanner ; Daron G. Davis ; Kamal H. Masaki ; Lenore J. Launer ; J David Curb ; Lon R. WhiteSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Hawaii.
- epidemiology : Constipation.
- pathology : Brain, Constipation, Lewy Bodies.
- Aged, Aged, 80 and over, Asian Americans, Humans, Incidence, Male, Postmortem Changes, Retrospective Studies.
Abstract
It is not known if constipation is associated with the preclinical phase of Parkinson's disease (PD), often characterized by the presence of incidental Lewy bodies (ILB). Such an association could provide evidence that constipation is an early symptom of PD. The purpose of this report is to examine the association between late-life bowel movement frequency and ILB. Bowel movement frequency was assessed from 1991 to 1993 in 245 men aged 71 to 93 years in the Honolulu-Asia Aging Study who later received postmortem examinations. All were without clinical PD and dementia. Brains were examined for ILB in the substantia nigra and locus ceruleus. Among the decedents, 30 men had ILB (12.2%). After age-adjustment, the percent of brains with ILB declined with increasing bowel movement frequency (P=0.013). For men with <1, 1, and >1 bowel movement/day, corresponding percents were 24.1, 13.5, and 6.5%. Findings persisted after additional adjustment for time to death, mid-life pack-years of smoking and coffee intake, physical activity, and cognitive function. Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes.
DOI: 10.1002/mds.21560
PubMed: 17523195
Affiliations:
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Abbott</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA. rda3e@virginia.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name></author><author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name></author><author><name sortKey="Davis, Daron G" sort="Davis, Daron G" uniqKey="Davis D" first="Daron G" last="Davis">Daron G. Davis</name></author><author><name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H" last="Masaki">Kamal H. Masaki</name></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name></author><author><name sortKey="Curb, J David" sort="Curb, J David" uniqKey="Curb J" first="J David" last="Curb">J David Curb</name></author><author><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R" last="White">Lon R. 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Abbott</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA. rda3e@virginia.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biostatistics and Epidemiology, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0717, and Veterans Affairs Pacific Islands Health Care System, Honolulu, HI</wicri:regionArea><placeName><region type="state">Hawaï</region></placeName></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name></author><author><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. 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White</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Asian Americans</term><term>Brain (pathology)</term><term>Constipation (epidemiology)</term><term>Constipation (pathology)</term><term>Hawaii (epidemiology)</term><term>Humans</term><term>Incidence</term><term>Lewy Bodies (pathology)</term><term>Male</term><term>Postmortem Changes</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Hawaii</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Constipation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Constipation</term><term>Lewy Bodies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Asian Americans</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Postmortem Changes</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is not known if constipation is associated with the preclinical phase of Parkinson's disease (PD), often characterized by the presence of incidental Lewy bodies (ILB). Such an association could provide evidence that constipation is an early symptom of PD. The purpose of this report is to examine the association between late-life bowel movement frequency and ILB. Bowel movement frequency was assessed from 1991 to 1993 in 245 men aged 71 to 93 years in the Honolulu-Asia Aging Study who later received postmortem examinations. All were without clinical PD and dementia. Brains were examined for ILB in the substantia nigra and locus ceruleus. Among the decedents, 30 men had ILB (12.2%). After age-adjustment, the percent of brains with ILB declined with increasing bowel movement frequency (P=0.013). For men with <1, 1, and >1 bowel movement/day, corresponding percents were 24.1, 13.5, and 6.5%. Findings persisted after additional adjustment for time to death, mid-life pack-years of smoking and coffee intake, physical activity, and cognitive function. Infrequent bowel movements are associated with ILB. Findings provide evidence that constipation can predate the extrapyramidal signs of PD. Constipation could be one of the earliest markers of the beginning of PD processes.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Hawaï</li></region></list><tree><noCountry><name sortKey="Curb, J David" sort="Curb, J David" uniqKey="Curb J" first="J David" last="Curb">J David Curb</name><name sortKey="Davis, Daron G" sort="Davis, Daron G" uniqKey="Davis D" first="Daron G" last="Davis">Daron G. Davis</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><name sortKey="Masaki, Kamal H" sort="Masaki, Kamal H" uniqKey="Masaki K" first="Kamal H" last="Masaki">Kamal H. Masaki</name><name sortKey="Petrovitch, Helen" sort="Petrovitch, Helen" uniqKey="Petrovitch H" first="Helen" last="Petrovitch">Helen Petrovitch</name><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G Webster" last="Ross">G Webster Ross</name><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline M" last="Tanner">Caroline M. Tanner</name><name sortKey="White, Lon R" sort="White, Lon R" uniqKey="White L" first="Lon R" last="White">Lon R. White</name></noCountry><country name="États-Unis"><region name="Hawaï"><name sortKey="Abbott, Robert D" sort="Abbott, Robert D" uniqKey="Abbott R" first="Robert D" last="Abbott">Robert D. Abbott</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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