Deep Brain Stimulation and Medication for Parkinsonian Tremor During Secondary Tasks
Identifieur interne : 001B90 ( Ncbi/Checkpoint ); précédent : 001B89; suivant : 001B91Deep Brain Stimulation and Medication for Parkinsonian Tremor During Secondary Tasks
Auteurs : Molly M. Sturman [États-Unis] ; David E. Vaillancourt [États-Unis] ; Leo Verhagen Metman [États-Unis] ; Diane K. Sierens [États-Unis] ; Roy A. E. Bakay [États-Unis] ; Daniel M. Corcos [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Combined Modality Therapy, Deep Brain Stimulation (methods), Electromyography, Female, Forearm, Humans, Male, Muscle, Skeletal (innervation), Parkinson Disease (drug therapy), Parkinson Disease (therapy), Subthalamic Nucleus (physiology), Wrist.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Cognition Disorders.
- drug therapy : Parkinson Disease.
- epidemiology : Cognition Disorders.
- innervation : Muscle, Skeletal.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Combined Modality Therapy, Electromyography, Female, Forearm, Humans, Male, Wrist.
Abstract
This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson’s disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.
Url:
DOI: 10.1002/mds.21518
PubMed: 17469210
PubMed Central: 2366974
Affiliations:
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Sturman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Movement Sciences, University of Illinois at Chicago, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Movement Sciences, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Movement Sciences, University of Illinois at Chicago, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Movement Sciences, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Bioengineering, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Neurosurgery, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Sierens, Diane K" sort="Sierens, Diane K" uniqKey="Sierens D" first="Diane K." last="Sierens">Diane K. Sierens</name><affiliation wicri:level="2"><nlm:aff id="A5"> Department of Neurological Surgery, Rockford Health System, Rockford, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Neurological Surgery, Rockford Health System, Rockford</wicri:cityArea></affiliation></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A4"> Department of Neurosurgery, Rush University Medical Center, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Neurosurgery, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Movement Sciences, University of Illinois at Chicago, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Movement Sciences, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Bioengineering, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A6"> Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea> Department of Physical Therapy, University of Illinois at Chicago, Chicago</wicri:cityArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation (methods)</term><term>Electromyography</term><term>Female</term><term>Forearm</term><term>Humans</term><term>Male</term><term>Muscle, Skeletal (innervation)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (physiology)</term><term>Wrist</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term><term>Electromyography</term><term>Female</term><term>Forearm</term><term>Humans</term><term>Male</term><term>Wrist</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson’s disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M." last="Sturman">Molly M. Sturman</name></region><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A. E." last="Bakay">Roy A. E. Bakay</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M." last="Corcos">Daniel M. Corcos</name><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name><name sortKey="Sierens, Diane K" sort="Sierens, Diane K" uniqKey="Sierens D" first="Diane K." last="Sierens">Diane K. Sierens</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E." last="Vaillancourt">David E. Vaillancourt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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