Deep brain stimulation and medication for parkinsonian tremor during secondary tasks.
Identifieur interne : 002749 ( PubMed/Corpus ); précédent : 002748; suivant : 002750Deep brain stimulation and medication for parkinsonian tremor during secondary tasks.
Auteurs : Molly M. Sturman ; David E. Vaillancourt ; Leo Verhagen Metman ; Diane K. Sierens ; Roy A E. Bakay ; Daniel M. CorcosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Antiparkinson Agents (therapeutic use), Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Combined Modality Therapy, Deep Brain Stimulation (methods), Electromyography, Female, Forearm, Humans, Male, Muscle, Skeletal (innervation), Parkinson Disease (drug therapy), Parkinson Disease (therapy), Subthalamic Nucleus (physiology), Wrist.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- diagnosis : Cognition Disorders.
- drug therapy : Parkinson Disease.
- epidemiology : Cognition Disorders.
- innervation : Muscle, Skeletal.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Combined Modality Therapy, Electromyography, Female, Forearm, Humans, Male, Wrist.
Abstract
This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.
DOI: 10.1002/mds.21518
PubMed: 17469210
Links to Exploration step
pubmed:17469210Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Deep brain stimulation and medication for parkinsonian tremor during secondary tasks.</title><author><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M" last="Sturman">Molly M. Sturman</name><affiliation><nlm:affiliation>Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA. msturm3@uic.edu</nlm:affiliation></affiliation></author><author><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E" last="Vaillancourt">David E. Vaillancourt</name></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name></author><author><name sortKey="Sierens, Diane K" sort="Sierens, Diane K" uniqKey="Sierens D" first="Diane K" last="Sierens">Diane K. Sierens</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A E" last="Bakay">Roy A E. Bakay</name></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M" last="Corcos">Daniel M. Corcos</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21518</idno><idno type="RBID">pubmed:17469210</idno><idno type="pmid">17469210</idno><idno type="wicri:Area/PubMed/Corpus">002749</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Deep brain stimulation and medication for parkinsonian tremor during secondary tasks.</title><author><name sortKey="Sturman, Molly M" sort="Sturman, Molly M" uniqKey="Sturman M" first="Molly M" last="Sturman">Molly M. Sturman</name><affiliation><nlm:affiliation>Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA. msturm3@uic.edu</nlm:affiliation></affiliation></author><author><name sortKey="Vaillancourt, David E" sort="Vaillancourt, David E" uniqKey="Vaillancourt D" first="David E" last="Vaillancourt">David E. Vaillancourt</name></author><author><name sortKey="Metman, Leo Verhagen" sort="Metman, Leo Verhagen" uniqKey="Metman L" first="Leo Verhagen" last="Metman">Leo Verhagen Metman</name></author><author><name sortKey="Sierens, Diane K" sort="Sierens, Diane K" uniqKey="Sierens D" first="Diane K" last="Sierens">Diane K. Sierens</name></author><author><name sortKey="Bakay, Roy A E" sort="Bakay, Roy A E" uniqKey="Bakay R" first="Roy A E" last="Bakay">Roy A E. Bakay</name></author><author><name sortKey="Corcos, Daniel M" sort="Corcos, Daniel M" uniqKey="Corcos D" first="Daniel M" last="Corcos">Daniel M. Corcos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (therapeutic use)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Combined Modality Therapy</term><term>Deep Brain Stimulation (methods)</term><term>Electromyography</term><term>Female</term><term>Forearm</term><term>Humans</term><term>Male</term><term>Muscle, Skeletal (innervation)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (physiology)</term><term>Wrist</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Combined Modality Therapy</term><term>Electromyography</term><term>Female</term><term>Forearm</term><term>Humans</term><term>Male</term><term>Wrist</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17469210</PMID><DateCreated><Year>2007</Year><Month>07</Month><Day>30</Day></DateCreated><DateCompleted><Year>2007</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>8</Issue><PubDate><Year>2007</Year><Month>Jun</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Deep brain stimulation and medication for parkinsonian tremor during secondary tasks.</ArticleTitle><Pagination><MedlinePgn>1157-63</MedlinePgn></Pagination><Abstract><AbstractText>This study examined the efficacy of subthalamic nucleus (STN), deep brain stimulation (DBS), and medication for resting tremor during performance of secondary tasks. Hand tremor was recorded using accelerometry and electromyography (EMG) from 10 patients with Parkinson's disease (PD) and ten matched control subjects. The PD subjects were examined off treatment, on STN DBS, on medication, and on STN DBS plus medication. In the first experiment, tremor was recorded in a quiet condition and during a cognitive task designed to enhance tremor. In the second experiment, tremor was recorded in a quiet condition and during isometric finger flexion (motor task) with the contralateral limb at 5% of the maximal voluntary contraction (MVC) that was designed to suppress tremor. Results showed that: (1) STN DBS and medication reduced tremor during a cognitive task that exacerbated tremor, (2) STN DBS normalized tremor frequency in both the quiet and cognitive task conditions, whereas tremor amplitude was only normalized in the quiet condition, (3) a secondary motor task reduced tremor in a similar manner to STN DBS. These findings demonstrate that STN DBS still suppresses tremor in the presence of a cognitive task. Furthermore, a secondary motor task of the opposite limb suppresses tremor to levels comparable to STN DBS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sturman</LastName><ForeName>Molly M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Movement Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA. msturm3@uic.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaillancourt</LastName><ForeName>David E</ForeName><Initials>DE</Initials></Author><Author ValidYN="Y"><LastName>Metman</LastName><ForeName>Leo Verhagen</ForeName><Initials>LV</Initials></Author><Author ValidYN="Y"><LastName>Sierens</LastName><ForeName>Diane K</ForeName><Initials>DK</Initials></Author><Author ValidYN="Y"><LastName>Bakay</LastName><ForeName>Roy A E</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Corcos</LastName><ForeName>Daniel M</ForeName><Initials>DM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS052318</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS052318-03</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS28127</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS40902</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS52318</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 MH067631</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Brain. 1986 Aug;109 ( Pt 4):739-57</RefSource><PMID Version="1">3730813</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 1992;7(1):2-13</RefSource><PMID Version="1">1557062</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4</RefSource><PMID Version="1">1564476</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 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MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003131">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D046690">Deep Brain Stimulation</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004576">Electromyography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005542">Forearm</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018482">Muscle, Skeletal</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000294">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020531">Subthalamic Nucleus</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014953">Wrist</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS45843</OtherID><OtherID Source="NLM">PMC2366974</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>5</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>9</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>5</Month><Day>1</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21518</ArticleId><ArticleId IdType="pubmed">17469210</ArticleId><ArticleId IdType="pmc">PMC2366974</ArticleId><ArticleId IdType="mid">NIHMS45843</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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