Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.
Identifieur interne : 001A97 ( Ncbi/Checkpoint ); précédent : 001A96; suivant : 001A98Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.
Auteurs : Ming Chi Shih [Brésil] ; Luiz Augusto Franco De Andrade ; Edson Amaro ; Andre Carvalho Felicio ; Henrique Ballalai Ferraz ; Jairo Wagner ; Marcelo Queiroz Hoexter ; Li Fu Lin ; Ying Kai Fu ; Jair Jesus Mari ; Sergio Tufik ; Rodrigo Affonseca BressanSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Corpus Striatum (radionuclide imaging), Depression (epidemiology), Dopamine (analysis), Female, Humans, Male, Middle Aged, Organotechnetium Compounds (diagnostic use), Parkinson Disease (psychology), Parkinson Disease (radionuclide imaging), Radiopharmaceuticals (diagnostic use), Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use).
- MESH :
- chemical , analysis : Dopamine.
- chemical , diagnostic use : Organotechnetium Compounds, Radiopharmaceuticals, Tropanes.
- epidemiology : Depression.
- psychology : Parkinson Disease.
- radionuclide imaging : Corpus Striatum, Parkinson Disease, Substantia Nigra.
- Adult, Age of Onset, Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.
Abstract
Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening.
DOI: 10.1002/mds.21315
PubMed: 17290452
Affiliations:
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last="Franco De Andrade">Luiz Augusto Franco De Andrade</name></author><author><name sortKey="Amaro, Edson" sort="Amaro, Edson" uniqKey="Amaro E" first="Edson" last="Amaro">Edson Amaro</name></author><author><name sortKey="Felicio, Andre Carvalho" sort="Felicio, Andre Carvalho" uniqKey="Felicio A" first="Andre Carvalho" last="Felicio">Andre Carvalho Felicio</name></author><author><name sortKey="Ferraz, Henrique Ballalai" sort="Ferraz, Henrique Ballalai" uniqKey="Ferraz H" first="Henrique Ballalai" last="Ferraz">Henrique Ballalai Ferraz</name></author><author><name sortKey="Wagner, Jairo" sort="Wagner, Jairo" uniqKey="Wagner J" first="Jairo" last="Wagner">Jairo Wagner</name></author><author><name sortKey="Hoexter, Marcelo Queiroz" sort="Hoexter, Marcelo Queiroz" uniqKey="Hoexter M" first="Marcelo Queiroz" last="Hoexter">Marcelo Queiroz Hoexter</name></author><author><name sortKey="Lin, Li Fu" sort="Lin, Li Fu" uniqKey="Lin L" first="Li Fu" last="Lin">Li Fu Lin</name></author><author><name sortKey="Fu, Ying Kai" sort="Fu, Ying Kai" uniqKey="Fu Y" first="Ying Kai" last="Fu">Ying Kai Fu</name></author><author><name sortKey="Mari, Jair Jesus" sort="Mari, Jair Jesus" uniqKey="Mari J" first="Jair Jesus" last="Mari">Jair Jesus Mari</name></author><author><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name></author><author><name sortKey="Bressan, Rodrigo Affonseca" sort="Bressan, Rodrigo Affonseca" uniqKey="Bressan R" first="Rodrigo Affonseca" last="Bressan">Rodrigo Affonseca Bressan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21315</idno><idno type="RBID">pubmed:17290452</idno><idno type="pmid">17290452</idno><idno type="wicri:Area/PubMed/Corpus">002842</idno><idno type="wicri:Area/PubMed/Curation">002842</idno><idno type="wicri:Area/PubMed/Checkpoint">002787</idno><idno 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Paulo</region></placeName></affiliation></author><author><name sortKey="Franco De Andrade, Luiz Augusto" sort="Franco De Andrade, Luiz Augusto" uniqKey="Franco De Andrade L" first="Luiz Augusto" last="Franco De Andrade">Luiz Augusto Franco De Andrade</name></author><author><name sortKey="Amaro, Edson" sort="Amaro, Edson" uniqKey="Amaro E" first="Edson" last="Amaro">Edson Amaro</name></author><author><name sortKey="Felicio, Andre Carvalho" sort="Felicio, Andre Carvalho" uniqKey="Felicio A" first="Andre Carvalho" last="Felicio">Andre Carvalho Felicio</name></author><author><name sortKey="Ferraz, Henrique Ballalai" sort="Ferraz, Henrique Ballalai" uniqKey="Ferraz H" first="Henrique Ballalai" last="Ferraz">Henrique Ballalai Ferraz</name></author><author><name sortKey="Wagner, Jairo" sort="Wagner, Jairo" uniqKey="Wagner J" first="Jairo" last="Wagner">Jairo Wagner</name></author><author><name sortKey="Hoexter, Marcelo Queiroz" sort="Hoexter, Marcelo Queiroz" uniqKey="Hoexter M" first="Marcelo Queiroz" last="Hoexter">Marcelo Queiroz Hoexter</name></author><author><name sortKey="Lin, Li Fu" sort="Lin, Li Fu" uniqKey="Lin L" first="Li Fu" last="Lin">Li Fu Lin</name></author><author><name sortKey="Fu, Ying Kai" sort="Fu, Ying Kai" uniqKey="Fu Y" first="Ying Kai" last="Fu">Ying Kai Fu</name></author><author><name sortKey="Mari, Jair Jesus" sort="Mari, Jair Jesus" uniqKey="Mari J" first="Jair Jesus" last="Mari">Jair Jesus Mari</name></author><author><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name></author><author><name sortKey="Bressan, Rodrigo Affonseca" sort="Bressan, Rodrigo Affonseca" uniqKey="Bressan R" first="Rodrigo Affonseca" last="Bressan">Rodrigo Affonseca Bressan</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Corpus Striatum (radionuclide imaging)</term><term>Depression (epidemiology)</term><term>Dopamine (analysis)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Organotechnetium Compounds (diagnostic use)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Substantia Nigra (radionuclide imaging)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Organotechnetium Compounds</term><term>Radiopharmaceuticals</term><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><noCountry><name sortKey="Amaro, Edson" sort="Amaro, Edson" uniqKey="Amaro E" first="Edson" last="Amaro">Edson Amaro</name><name sortKey="Bressan, Rodrigo Affonseca" sort="Bressan, Rodrigo Affonseca" uniqKey="Bressan R" first="Rodrigo Affonseca" last="Bressan">Rodrigo Affonseca Bressan</name><name sortKey="Felicio, Andre Carvalho" sort="Felicio, Andre Carvalho" uniqKey="Felicio A" first="Andre Carvalho" last="Felicio">Andre Carvalho Felicio</name><name sortKey="Ferraz, Henrique Ballalai" sort="Ferraz, Henrique Ballalai" uniqKey="Ferraz H" first="Henrique Ballalai" last="Ferraz">Henrique Ballalai Ferraz</name><name sortKey="Franco De Andrade, Luiz Augusto" sort="Franco De Andrade, Luiz Augusto" uniqKey="Franco De Andrade L" first="Luiz Augusto" last="Franco De Andrade">Luiz Augusto Franco De Andrade</name><name sortKey="Fu, Ying Kai" sort="Fu, Ying Kai" uniqKey="Fu Y" first="Ying Kai" last="Fu">Ying Kai Fu</name><name sortKey="Hoexter, Marcelo Queiroz" sort="Hoexter, Marcelo Queiroz" uniqKey="Hoexter M" first="Marcelo Queiroz" last="Hoexter">Marcelo Queiroz Hoexter</name><name sortKey="Lin, Li Fu" sort="Lin, Li Fu" uniqKey="Lin L" first="Li Fu" last="Lin">Li Fu Lin</name><name sortKey="Mari, Jair Jesus" sort="Mari, Jair Jesus" uniqKey="Mari J" first="Jair Jesus" last="Mari">Jair Jesus Mari</name><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name><name sortKey="Wagner, Jairo" sort="Wagner, Jairo" uniqKey="Wagner J" first="Jairo" last="Wagner">Jairo Wagner</name></noCountry><country name="Brésil"><region name="État de São Paulo"><name sortKey="Shih, Ming Chi" sort="Shih, Ming Chi" uniqKey="Shih M" first="Ming Chi" last="Shih">Ming Chi Shih</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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