Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.
Identifieur interne : 001A97 ( Ncbi/Merge ); précédent : 001A96; suivant : 001A98Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.
Auteurs : Ming Chi Shih [Brésil] ; Luiz Augusto Franco De Andrade ; Edson Amaro ; Andre Carvalho Felicio ; Henrique Ballalai Ferraz ; Jairo Wagner ; Marcelo Queiroz Hoexter ; Li Fu Lin ; Ying Kai Fu ; Jair Jesus Mari ; Sergio Tufik ; Rodrigo Affonseca BressanSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2007.
English descriptors
- KwdEn :
- Adult, Age of Onset, Aged, Corpus Striatum (radionuclide imaging), Depression (epidemiology), Dopamine (analysis), Female, Humans, Male, Middle Aged, Organotechnetium Compounds (diagnostic use), Parkinson Disease (psychology), Parkinson Disease (radionuclide imaging), Radiopharmaceuticals (diagnostic use), Substantia Nigra (radionuclide imaging), Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use).
- MESH :
- chemical , analysis : Dopamine.
- chemical , diagnostic use : Organotechnetium Compounds, Radiopharmaceuticals, Tropanes.
- epidemiology : Depression.
- psychology : Parkinson Disease.
- radionuclide imaging : Corpus Striatum, Parkinson Disease, Substantia Nigra.
- Adult, Age of Onset, Aged, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon.
Abstract
Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening.
DOI: 10.1002/mds.21315
PubMed: 17290452
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last="Franco De Andrade">Luiz Augusto Franco De Andrade</name></author><author><name sortKey="Amaro, Edson" sort="Amaro, Edson" uniqKey="Amaro E" first="Edson" last="Amaro">Edson Amaro</name></author><author><name sortKey="Felicio, Andre Carvalho" sort="Felicio, Andre Carvalho" uniqKey="Felicio A" first="Andre Carvalho" last="Felicio">Andre Carvalho Felicio</name></author><author><name sortKey="Ferraz, Henrique Ballalai" sort="Ferraz, Henrique Ballalai" uniqKey="Ferraz H" first="Henrique Ballalai" last="Ferraz">Henrique Ballalai Ferraz</name></author><author><name sortKey="Wagner, Jairo" sort="Wagner, Jairo" uniqKey="Wagner J" first="Jairo" last="Wagner">Jairo Wagner</name></author><author><name sortKey="Hoexter, Marcelo Queiroz" sort="Hoexter, Marcelo Queiroz" uniqKey="Hoexter M" first="Marcelo Queiroz" last="Hoexter">Marcelo Queiroz Hoexter</name></author><author><name sortKey="Lin, Li Fu" sort="Lin, Li Fu" uniqKey="Lin L" first="Li Fu" last="Lin">Li Fu Lin</name></author><author><name sortKey="Fu, Ying Kai" sort="Fu, Ying Kai" uniqKey="Fu Y" first="Ying Kai" last="Fu">Ying Kai Fu</name></author><author><name sortKey="Mari, Jair Jesus" sort="Mari, Jair Jesus" uniqKey="Mari J" first="Jair Jesus" last="Mari">Jair Jesus Mari</name></author><author><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name></author><author><name sortKey="Bressan, Rodrigo Affonseca" sort="Bressan, Rodrigo Affonseca" uniqKey="Bressan R" first="Rodrigo Affonseca" last="Bressan">Rodrigo Affonseca Bressan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1002/mds.21315</idno><idno type="RBID">pubmed:17290452</idno><idno type="pmid">17290452</idno><idno type="wicri:Area/PubMed/Corpus">002842</idno><idno type="wicri:Area/PubMed/Curation">002842</idno><idno type="wicri:Area/PubMed/Checkpoint">002787</idno><idno type="wicri:Area/Ncbi/Merge">001A97</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.</title><author><name sortKey="Shih, Ming Chi" sort="Shih, Ming Chi" uniqKey="Shih M" first="Ming Chi" last="Shih">Ming Chi Shih</name><affiliation wicri:level="3"><nlm:affiliation>Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo, Brazil. mingchi@psiquiatria.epm.br</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Franco De Andrade, Luiz Augusto" sort="Franco De Andrade, Luiz Augusto" uniqKey="Franco De Andrade L" first="Luiz Augusto" last="Franco De Andrade">Luiz Augusto Franco De Andrade</name></author><author><name sortKey="Amaro, Edson" sort="Amaro, Edson" uniqKey="Amaro E" first="Edson" last="Amaro">Edson Amaro</name></author><author><name sortKey="Felicio, Andre Carvalho" sort="Felicio, Andre Carvalho" uniqKey="Felicio A" first="Andre Carvalho" last="Felicio">Andre Carvalho Felicio</name></author><author><name sortKey="Ferraz, Henrique Ballalai" sort="Ferraz, Henrique Ballalai" uniqKey="Ferraz H" first="Henrique Ballalai" last="Ferraz">Henrique Ballalai Ferraz</name></author><author><name sortKey="Wagner, Jairo" sort="Wagner, Jairo" uniqKey="Wagner J" first="Jairo" last="Wagner">Jairo Wagner</name></author><author><name sortKey="Hoexter, Marcelo Queiroz" sort="Hoexter, Marcelo Queiroz" uniqKey="Hoexter M" first="Marcelo Queiroz" last="Hoexter">Marcelo Queiroz Hoexter</name></author><author><name sortKey="Lin, Li Fu" sort="Lin, Li Fu" uniqKey="Lin L" first="Li Fu" last="Lin">Li Fu Lin</name></author><author><name sortKey="Fu, Ying Kai" sort="Fu, Ying Kai" uniqKey="Fu Y" first="Ying Kai" last="Fu">Ying Kai Fu</name></author><author><name sortKey="Mari, Jair Jesus" sort="Mari, Jair Jesus" uniqKey="Mari J" first="Jair Jesus" last="Mari">Jair Jesus Mari</name></author><author><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name></author><author><name sortKey="Bressan, Rodrigo Affonseca" sort="Bressan, Rodrigo Affonseca" uniqKey="Bressan R" first="Rodrigo Affonseca" last="Bressan">Rodrigo Affonseca Bressan</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Corpus Striatum (radionuclide imaging)</term><term>Depression (epidemiology)</term><term>Dopamine (analysis)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Organotechnetium Compounds (diagnostic use)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Substantia Nigra (radionuclide imaging)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Organotechnetium Compounds</term><term>Radiopharmaceuticals</term><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age of Onset</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17290452</PMID><DateCreated><Year>2007</Year><Month>05</Month><Day>01</Day></DateCreated><DateCompleted><Year>2007</Year><Month>07</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>22</Volume><Issue>6</Issue><PubDate><Year>2007</Year><Month>Apr</Month><Day>30</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Higher nigrostriatal dopamine neuron loss in early than late onset Parkinson's disease?--a [99mTc]-TRODAT-1 SPECT study.</ArticleTitle><Pagination><MedlinePgn>863-6</MedlinePgn></Pagination><Abstract><AbstractText>Early-onset Parkinson's disease (EOPD) is distinct from the classic late-onset PD (LOPD) because of its slower disease progression. The aim of this study was to compare dopamine neuronal loss in EOPD with that of LOPD with the same disease duration, through dopamine transporter (DAT) estimation. Fourteen patients, seven EOPD (<50 years) and seven LOPD, matched for disease duration were scanned with [(99m)Tc]-TRODAT-1-SPECT (INER-Taiwan), and were assessed with standard PD scales. EOPD patients had 34% lower striatal DAT binding potential (BP) compared with that of LOPD patients (BP = 0.29 +/- 0.12, BP = 0.44 +/- 0.12, P < 0.02) with similar PD severity. These results suggest that EOPD patients have greater dopamine density loss than LOPD patients without motor-symptom worsening.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shih</LastName><ForeName>Ming Chi</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Laboratório Interdiciplinar de Neuroimagem e Cognição (LiNC), Universidade Federal de São Paulo, Sao Paulo, Brazil. mingchi@psiquiatria.epm.br</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franco de Andrade</LastName><ForeName>Luiz Augusto</ForeName><Initials>LA</Initials></Author><Author ValidYN="Y"><LastName>Amaro</LastName><ForeName>Edson</ForeName><Initials>E</Initials><Suffix>Jr</Suffix></Author><Author ValidYN="Y"><LastName>Felicio</LastName><ForeName>Andre Carvalho</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Ferraz</LastName><ForeName>Henrique Ballalai</ForeName><Initials>HB</Initials></Author><Author ValidYN="Y"><LastName>Wagner</LastName><ForeName>Jairo</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hoexter</LastName><ForeName>Marcelo Queiroz</ForeName><Initials>MQ</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Li Fu</ForeName><Initials>LF</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Ying Kai</ForeName><Initials>YK</Initials></Author><Author ValidYN="Y"><LastName>Mari</LastName><ForeName>Jair Jesus</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Tufik</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Bressan</LastName><ForeName>Rodrigo Affonseca</ForeName><Initials>RA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015609">Organotechnetium Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014326">Tropanes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C104196">technetium Tc 99m TRODAT-1</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017668">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003342">Corpus Striatum</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003863">Depression</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004298">Dopamine</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000032">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015609">Organotechnetium Compounds</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019275">Radiopharmaceuticals</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000176">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013378">Substantia Nigra</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000531">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015899">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014326">Tropanes</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000176">diagnostic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>2</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>7</Month><Day>13</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>2</Month><Day>10</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1002/mds.21315</ArticleId><ArticleId IdType="pubmed">17290452</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><noCountry><name sortKey="Amaro, Edson" sort="Amaro, Edson" uniqKey="Amaro E" first="Edson" last="Amaro">Edson Amaro</name><name sortKey="Bressan, Rodrigo Affonseca" sort="Bressan, Rodrigo Affonseca" uniqKey="Bressan R" first="Rodrigo Affonseca" last="Bressan">Rodrigo Affonseca Bressan</name><name sortKey="Felicio, Andre Carvalho" sort="Felicio, Andre Carvalho" uniqKey="Felicio A" first="Andre Carvalho" last="Felicio">Andre Carvalho Felicio</name><name sortKey="Ferraz, Henrique Ballalai" sort="Ferraz, Henrique Ballalai" uniqKey="Ferraz H" first="Henrique Ballalai" last="Ferraz">Henrique Ballalai Ferraz</name><name sortKey="Franco De Andrade, Luiz Augusto" sort="Franco De Andrade, Luiz Augusto" uniqKey="Franco De Andrade L" first="Luiz Augusto" last="Franco De Andrade">Luiz Augusto Franco De Andrade</name><name sortKey="Fu, Ying Kai" sort="Fu, Ying Kai" uniqKey="Fu Y" first="Ying Kai" last="Fu">Ying Kai Fu</name><name sortKey="Hoexter, Marcelo Queiroz" sort="Hoexter, Marcelo Queiroz" uniqKey="Hoexter M" first="Marcelo Queiroz" last="Hoexter">Marcelo Queiroz Hoexter</name><name sortKey="Lin, Li Fu" sort="Lin, Li Fu" uniqKey="Lin L" first="Li Fu" last="Lin">Li Fu Lin</name><name sortKey="Mari, Jair Jesus" sort="Mari, Jair Jesus" uniqKey="Mari J" first="Jair Jesus" last="Mari">Jair Jesus Mari</name><name sortKey="Tufik, Sergio" sort="Tufik, Sergio" uniqKey="Tufik S" first="Sergio" last="Tufik">Sergio Tufik</name><name sortKey="Wagner, Jairo" sort="Wagner, Jairo" uniqKey="Wagner J" first="Jairo" last="Wagner">Jairo Wagner</name></noCountry><country name="Brésil"><region name="État de São Paulo"><name sortKey="Shih, Ming Chi" sort="Shih, Ming Chi" uniqKey="Shih M" first="Ming Chi" last="Shih">Ming Chi 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