Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease.
Identifieur interne : 001740 ( Ncbi/Checkpoint ); précédent : 001739; suivant : 001741Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease.
Auteurs : Michela Barichella [Italie] ; Agnieszka Marczewska ; Roberta De Notaris ; Antonella Vairo ; Cinzia Baldo ; Andrea Mauri ; Chiara Savardi ; Gianni PezzoliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Combined Modality Therapy, Cross-Over Studies, Diet, Protein-Restricted (adverse effects), Drug Therapy, Combination, Female, Food-Drug Interactions, Humans, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Middle Aged, Neurologic Examination, Parkinson Disease (diet therapy), Parkinson Disease (physiopathology), Patient Satisfaction, Pilot Projects, Postprandial Period (physiology), Single-Blind Method.
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Levodopa.
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- adverse effects : Diet, Protein-Restricted.
- diet therapy : Parkinson Disease.
- physiology : Postprandial Period.
- physiopathology : Parkinson Disease.
- Aged, Combined Modality Therapy, Cross-Over Studies, Drug Therapy, Combination, Female, Food-Drug Interactions, Humans, Male, Middle Aged, Neurologic Examination, Patient Satisfaction, Pilot Projects, Single-Blind Method.
Abstract
Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low-protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross-over, single-blind, pilot clinical trial comparing a 2-month balanced diet with a 2-month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 +/- 73 min vs. 79 +/- 72 min and total off, 164 +/- 148 min vs. 271 +/- 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 +/- 2.7 hr vs. 4.7 +/- 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, -1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed.
DOI: 10.1002/mds.21003
PubMed: 16773618
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002B96
- to stream PubMed, to step Curation: 002B96
- to stream PubMed, to step Checkpoint: 002A93
- to stream Ncbi, to step Merge: 001740
- to stream Ncbi, to step Curation: 001740
Links to Exploration step
pubmed:16773618Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease.</title>
<author><name sortKey="Barichella, Michela" sort="Barichella, Michela" uniqKey="Barichella M" first="Michela" last="Barichella">Michela Barichella</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy. barichella@parkinson.it</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marczewska, Agnieszka" sort="Marczewska, Agnieszka" uniqKey="Marczewska A" first="Agnieszka" last="Marczewska">Agnieszka Marczewska</name>
</author>
<author><name sortKey="De Notaris, Roberta" sort="De Notaris, Roberta" uniqKey="De Notaris R" first="Roberta" last="De Notaris">Roberta De Notaris</name>
</author>
<author><name sortKey="Vairo, Antonella" sort="Vairo, Antonella" uniqKey="Vairo A" first="Antonella" last="Vairo">Antonella Vairo</name>
</author>
<author><name sortKey="Baldo, Cinzia" sort="Baldo, Cinzia" uniqKey="Baldo C" first="Cinzia" last="Baldo">Cinzia Baldo</name>
</author>
<author><name sortKey="Mauri, Andrea" sort="Mauri, Andrea" uniqKey="Mauri A" first="Andrea" last="Mauri">Andrea Mauri</name>
</author>
<author><name sortKey="Savardi, Chiara" sort="Savardi, Chiara" uniqKey="Savardi C" first="Chiara" last="Savardi">Chiara Savardi</name>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2006">2006</date>
<idno type="doi">10.1002/mds.21003</idno>
<idno type="RBID">pubmed:16773618</idno>
<idno type="pmid">16773618</idno>
<idno type="wicri:Area/PubMed/Corpus">002B96</idno>
<idno type="wicri:Area/PubMed/Curation">002B96</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002A93</idno>
<idno type="wicri:Area/Ncbi/Merge">001740</idno>
<idno type="wicri:Area/Ncbi/Curation">001740</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001740</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease.</title>
<author><name sortKey="Barichella, Michela" sort="Barichella, Michela" uniqKey="Barichella M" first="Michela" last="Barichella">Michela Barichella</name>
<affiliation wicri:level="3"><nlm:affiliation>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan, Italy. barichella@parkinson.it</nlm:affiliation>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Clinical Nutrition Unit, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marczewska, Agnieszka" sort="Marczewska, Agnieszka" uniqKey="Marczewska A" first="Agnieszka" last="Marczewska">Agnieszka Marczewska</name>
</author>
<author><name sortKey="De Notaris, Roberta" sort="De Notaris, Roberta" uniqKey="De Notaris R" first="Roberta" last="De Notaris">Roberta De Notaris</name>
</author>
<author><name sortKey="Vairo, Antonella" sort="Vairo, Antonella" uniqKey="Vairo A" first="Antonella" last="Vairo">Antonella Vairo</name>
</author>
<author><name sortKey="Baldo, Cinzia" sort="Baldo, Cinzia" uniqKey="Baldo C" first="Cinzia" last="Baldo">Cinzia Baldo</name>
</author>
<author><name sortKey="Mauri, Andrea" sort="Mauri, Andrea" uniqKey="Mauri A" first="Andrea" last="Mauri">Andrea Mauri</name>
</author>
<author><name sortKey="Savardi, Chiara" sort="Savardi, Chiara" uniqKey="Savardi C" first="Chiara" last="Savardi">Chiara Savardi</name>
</author>
<author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2006" type="published">2006</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (administration & dosage)</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Combined Modality Therapy</term>
<term>Cross-Over Studies</term>
<term>Diet, Protein-Restricted (adverse effects)</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Food-Drug Interactions</term>
<term>Humans</term>
<term>Levodopa (administration & dosage)</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurologic Examination</term>
<term>Parkinson Disease (diet therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Patient Satisfaction</term>
<term>Pilot Projects</term>
<term>Postprandial Period (physiology)</term>
<term>Single-Blind Method</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diet, Protein-Restricted</term>
</keywords>
<keywords scheme="MESH" qualifier="diet therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Postprandial Period</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Combined Modality Therapy</term>
<term>Cross-Over Studies</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Food-Drug Interactions</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurologic Examination</term>
<term>Patient Satisfaction</term>
<term>Pilot Projects</term>
<term>Single-Blind Method</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Protein intake interferes with levodopa therapy. Patients with advanced Parkinson's disease (PD) should restrict daily protein intake and shift protein intake to the evening. For further reduction of protein intake in the first part of the day, special low-protein products (LPP) should be used instead of normal food products at breakfast and lunch. We studied the efficacy of LPP on postprandial off periods, in PD patients on levodopa therapy. The methods included a randomized, cross-over, single-blind, pilot clinical trial comparing a 2-month balanced diet with a 2-month LPP diet in 18 PD patients with motor fluctuations. The off phases were significantly shorter after LPP diet than after balanced diet (postprandial off, 49 +/- 73 min vs. 79 +/- 72 min and total off, 164 +/- 148 min vs. 271 +/- 174 min, both P < 0.0001). Moreover, a reduction in total off time during LPP diet (3.3 +/- 2.7 hr vs. 4.7 +/- 3.3 hr, P < 0.0001), occurred also in the 9 patients who did not experience subjective benefit. No significant changes in hematological and biochemical variables or body composition were recorded; a slight reduction in body weight (mean, -1.8%) was observed. Consumption of LPP in the first part of the day ameliorates off periods in PD patients, but additional studies including pharmacokinetics are needed.</div>
</front>
</TEI>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Lombardie</li>
</region>
<settlement><li>Milan</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Baldo, Cinzia" sort="Baldo, Cinzia" uniqKey="Baldo C" first="Cinzia" last="Baldo">Cinzia Baldo</name>
<name sortKey="De Notaris, Roberta" sort="De Notaris, Roberta" uniqKey="De Notaris R" first="Roberta" last="De Notaris">Roberta De Notaris</name>
<name sortKey="Marczewska, Agnieszka" sort="Marczewska, Agnieszka" uniqKey="Marczewska A" first="Agnieszka" last="Marczewska">Agnieszka Marczewska</name>
<name sortKey="Mauri, Andrea" sort="Mauri, Andrea" uniqKey="Mauri A" first="Andrea" last="Mauri">Andrea Mauri</name>
<name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
<name sortKey="Savardi, Chiara" sort="Savardi, Chiara" uniqKey="Savardi C" first="Chiara" last="Savardi">Chiara Savardi</name>
<name sortKey="Vairo, Antonella" sort="Vairo, Antonella" uniqKey="Vairo A" first="Antonella" last="Vairo">Antonella Vairo</name>
</noCountry>
<country name="Italie"><region name="Lombardie"><name sortKey="Barichella, Michela" sort="Barichella, Michela" uniqKey="Barichella M" first="Michela" last="Barichella">Michela Barichella</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001740 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 001740 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= pubmed:16773618 |texte= Special low-protein foods ameliorate postprandial off in patients with advanced Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:16773618" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MovDisordV3
![]() | This area was generated with Dilib version V0.6.23. | ![]() |