Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life.
Identifieur interne : 001654 ( Ncbi/Checkpoint ); précédent : 001653; suivant : 001655Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson's disease and depression: effect on quality of life.
Auteurs : Angelo Antonini [Italie] ; Silvana Tesei ; Anna Zecchinelli ; Paolo Barone ; Danilo De Gaspari ; Margherita Canesi ; Giorgio Sacilotto ; Nicoletta Meucci ; Claudio Mariani ; Gianni PezzoliSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.
English descriptors
- KwdEn :
- Amitriptyline (therapeutic use), Antidepressive Agents (therapeutic use), Depression (etiology), Depression (prevention & control), Female, Humans, Male, Middle Aged, Parkinson Disease (psychology), Quality of Life, Serotonin Uptake Inhibitors (therapeutic use), Sertraline (therapeutic use), Single-Blind Method.
- MESH :
- chemical , therapeutic use : Amitriptyline, Antidepressive Agents, Serotonin Uptake Inhibitors, Sertraline.
- etiology : Depression.
- prevention & control : Depression.
- psychology : Parkinson Disease.
- Female, Humans, Male, Middle Aged, Quality of Life, Single-Blind Method.
Abstract
We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study. Both drugs significantly reduced the Hamilton Depression Rating Scale (HDRS-17) score. Completion rate was 75% for sertraline (12 of 16) and 73% for amitriptyline (11 of 15). Responder rate (HDRS-17 score reduction >/= 50%) was 83.3% for sertraline and 72.7% for amitriptyline. Sertraline but not amitriptyline treatment determined a significant benefit on quality of life (PDQ-39 scale). We found no change in Unified Parkinson's Disease Rating Scale scores. However, the improvement in specific PDQ-39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self-perception of motor function and further emphasizes the need for its treatment.
DOI: 10.1002/mds.20895
PubMed: 16637039
Affiliations:
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wicri:level="3"><nlm:affiliation>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Parkinson Institute, Istituti Clinici di Perfezionamento, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Tesei, Silvana" sort="Tesei, Silvana" uniqKey="Tesei S" first="Silvana" last="Tesei">Silvana Tesei</name></author><author><name sortKey="Zecchinelli, Anna" sort="Zecchinelli, Anna" uniqKey="Zecchinelli A" first="Anna" last="Zecchinelli">Anna Zecchinelli</name></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name></author><author><name sortKey="De Gaspari, Danilo" sort="De Gaspari, Danilo" uniqKey="De Gaspari D" first="Danilo" last="De Gaspari">Danilo De Gaspari</name></author><author><name sortKey="Canesi, Margherita" sort="Canesi, Margherita" uniqKey="Canesi M" first="Margherita" last="Canesi">Margherita Canesi</name></author><author><name sortKey="Sacilotto, Giorgio" sort="Sacilotto, Giorgio" uniqKey="Sacilotto G" first="Giorgio" last="Sacilotto">Giorgio Sacilotto</name></author><author><name sortKey="Meucci, Nicoletta" sort="Meucci, Nicoletta" uniqKey="Meucci N" first="Nicoletta" last="Meucci">Nicoletta Meucci</name></author><author><name sortKey="Mariani, Claudio" sort="Mariani, Claudio" uniqKey="Mariani C" first="Claudio" last="Mariani">Claudio Mariani</name></author><author><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amitriptyline (therapeutic use)</term><term>Antidepressive Agents (therapeutic use)</term><term>Depression (etiology)</term><term>Depression (prevention & control)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (psychology)</term><term>Quality of Life</term><term>Serotonin Uptake Inhibitors (therapeutic use)</term><term>Sertraline (therapeutic use)</term><term>Single-Blind Method</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Amitriptyline</term><term>Antidepressive Agents</term><term>Serotonin Uptake Inhibitors</term><term>Sertraline</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Depression</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Quality of Life</term><term>Single-Blind Method</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We assessed the effect of 3-month treatment of sertraline (50 mg) or low-dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single-blind randomized study. Both drugs significantly reduced the Hamilton Depression Rating Scale (HDRS-17) score. Completion rate was 75% for sertraline (12 of 16) and 73% for amitriptyline (11 of 15). Responder rate (HDRS-17 score reduction >/= 50%) was 83.3% for sertraline and 72.7% for amitriptyline. Sertraline but not amitriptyline treatment determined a significant benefit on quality of life (PDQ-39 scale). We found no change in Unified Parkinson's Disease Rating Scale scores. However, the improvement in specific PDQ-39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self-perception of motor function and further emphasizes the need for its treatment.</div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Lombardie</li></region><settlement><li>Milan</li></settlement></list><tree><noCountry><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><name sortKey="Canesi, Margherita" sort="Canesi, Margherita" uniqKey="Canesi M" first="Margherita" last="Canesi">Margherita Canesi</name><name sortKey="De Gaspari, Danilo" sort="De Gaspari, Danilo" uniqKey="De Gaspari D" first="Danilo" last="De Gaspari">Danilo De Gaspari</name><name sortKey="Mariani, Claudio" sort="Mariani, Claudio" uniqKey="Mariani C" first="Claudio" last="Mariani">Claudio Mariani</name><name sortKey="Meucci, Nicoletta" sort="Meucci, Nicoletta" uniqKey="Meucci N" first="Nicoletta" last="Meucci">Nicoletta Meucci</name><name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name><name sortKey="Sacilotto, Giorgio" sort="Sacilotto, Giorgio" uniqKey="Sacilotto G" first="Giorgio" last="Sacilotto">Giorgio Sacilotto</name><name sortKey="Tesei, Silvana" sort="Tesei, Silvana" uniqKey="Tesei S" first="Silvana" last="Tesei">Silvana Tesei</name><name sortKey="Zecchinelli, Anna" sort="Zecchinelli, Anna" uniqKey="Zecchinelli A" first="Anna" last="Zecchinelli">Anna Zecchinelli</name></noCountry><country name="Italie"><region name="Lombardie"><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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