Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease.
Identifieur interne : 001257 ( Ncbi/Checkpoint ); précédent : 001256; suivant : 001258Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease.
Auteurs : Reinoud C. Klein [Pays-Bas] ; Bauke M. De Jong ; Joeke J. De Vries ; Klaus L. LeendersSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2005.
English descriptors
- KwdEn :
- Aged, Blood Glucose (metabolism), Brain Mapping, Cerebral Cortex (metabolism), Cerebral Cortex (radionuclide imaging), Female, Fluorodeoxyglucose F18 (metabolism), Humans, Image Processing, Computer-Assisted (methods), Male, Middle Aged, Parkinson Disease (metabolism), Parkinson Disease (radionuclide imaging), Positron-Emission Tomography (methods), Regional Blood Flow (physiology), Supranuclear Palsy, Progressive (metabolism), Supranuclear Palsy, Progressive (radionuclide imaging).
- MESH :
- chemical , metabolism : Blood Glucose, Fluorodeoxyglucose F18.
- metabolism : Cerebral Cortex, Parkinson Disease, Supranuclear Palsy, Progressive.
- methods : Image Processing, Computer-Assisted, Positron-Emission Tomography.
- physiology : Regional Blood Flow.
- radionuclide imaging : Cerebral Cortex, Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Brain Mapping, Female, Humans, Male, Middle Aged.
Abstract
The differentiation between progressive supranuclear palsy (PSP) and Parkinson's disease (PD) may be difficult, especially in the early stages of disease. Positron emission tomography potentially provides a tool for making such a distinction. To identify key features in the spatial distributions of cerebral glucose metabolism, 18F-fluorodeoxyglucose (FDG) measurements of 10 patients with probable or possible PSP were directly compared with those of 9 PD patients. This analysis was done with statistic parametric mapping. After normalization of global brain uptake, in PSP, relative uptake of FDG was reduced in the caudal (motor) part of the anterior cingulate gyrus (Brodmann's area BA 24; P < 0.05, corrected for multiple comparisons). At a lower threshold, an additional decrease was present in the dorsal mesencephalon. In PD, relative hypometabolism was seen in extrastriate visual, ventrolateral temporal, posterior parietal, and orbitofrontal regions. Only reduction in the right fusiform gyrus and the lateral extrastriate visual cortex reached statistical significance. We concluded that particularly the reduction of medial frontal metabolism may be a valuable diagnostic imaging parameter in distinguishing PSP from PD. For PD, a possible association between occipitotemporal FDG decrease and vulnerability to hallucinations is suggested.
DOI: 10.1002/mds.20493
PubMed: 15858809
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease.</title><author><name sortKey="Klein, Reinoud C" sort="Klein, Reinoud C" uniqKey="Klein R" first="Reinoud C" last="Klein">Reinoud C. Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Hospital Groningen</wicri:regionArea><wicri:noRegion>University Hospital Groningen</wicri:noRegion></affiliation></author><author><name sortKey="De Jong, Bauke M" sort="De Jong, Bauke M" uniqKey="De Jong B" first="Bauke M" last="De Jong">Bauke M. De Jong</name></author><author><name sortKey="De Vries, Joeke J" sort="De Vries, Joeke J" uniqKey="De Vries J" first="Joeke J" last="De Vries">Joeke J. De Vries</name></author><author><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L" last="Leenders">Klaus L. Leenders</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1002/mds.20493</idno><idno type="RBID">pubmed:15858809</idno><idno type="pmid">15858809</idno><idno type="wicri:Area/PubMed/Corpus">003055</idno><idno type="wicri:Area/PubMed/Curation">003055</idno><idno type="wicri:Area/PubMed/Checkpoint">003166</idno><idno type="wicri:Area/Ncbi/Merge">001257</idno><idno type="wicri:Area/Ncbi/Curation">001257</idno><idno type="wicri:Area/Ncbi/Checkpoint">001257</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Direct comparison between regional cerebral metabolism in progressive supranuclear palsy and Parkinson's disease.</title><author><name sortKey="Klein, Reinoud C" sort="Klein, Reinoud C" uniqKey="Klein R" first="Reinoud C" last="Klein">Reinoud C. Klein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University Hospital Groningen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Hospital Groningen</wicri:regionArea><wicri:noRegion>University Hospital Groningen</wicri:noRegion></affiliation></author><author><name sortKey="De Jong, Bauke M" sort="De Jong, Bauke M" uniqKey="De Jong B" first="Bauke M" last="De Jong">Bauke M. De Jong</name></author><author><name sortKey="De Vries, Joeke J" sort="De Vries, Joeke J" uniqKey="De Vries J" first="Joeke J" last="De Vries">Joeke J. De Vries</name></author><author><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L" last="Leenders">Klaus L. Leenders</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood Glucose (metabolism)</term><term>Brain Mapping</term><term>Cerebral Cortex (metabolism)</term><term>Cerebral Cortex (radionuclide imaging)</term><term>Female</term><term>Fluorodeoxyglucose F18 (metabolism)</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Positron-Emission Tomography (methods)</term><term>Regional Blood Flow (physiology)</term><term>Supranuclear Palsy, Progressive (metabolism)</term><term>Supranuclear Palsy, Progressive (radionuclide imaging)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebral Cortex</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Regional Blood Flow</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Cerebral Cortex</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The differentiation between progressive supranuclear palsy (PSP) and Parkinson's disease (PD) may be difficult, especially in the early stages of disease. Positron emission tomography potentially provides a tool for making such a distinction. To identify key features in the spatial distributions of cerebral glucose metabolism, 18F-fluorodeoxyglucose (FDG) measurements of 10 patients with probable or possible PSP were directly compared with those of 9 PD patients. This analysis was done with statistic parametric mapping. After normalization of global brain uptake, in PSP, relative uptake of FDG was reduced in the caudal (motor) part of the anterior cingulate gyrus (Brodmann's area BA 24; P < 0.05, corrected for multiple comparisons). At a lower threshold, an additional decrease was present in the dorsal mesencephalon. In PD, relative hypometabolism was seen in extrastriate visual, ventrolateral temporal, posterior parietal, and orbitofrontal regions. Only reduction in the right fusiform gyrus and the lateral extrastriate visual cortex reached statistical significance. We concluded that particularly the reduction of medial frontal metabolism may be a valuable diagnostic imaging parameter in distinguishing PSP from PD. For PD, a possible association between occipitotemporal FDG decrease and vulnerability to hallucinations is suggested.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="De Jong, Bauke M" sort="De Jong, Bauke M" uniqKey="De Jong B" first="Bauke M" last="De Jong">Bauke M. De Jong</name><name sortKey="De Vries, Joeke J" sort="De Vries, Joeke J" uniqKey="De Vries J" first="Joeke J" last="De Vries">Joeke J. De Vries</name><name sortKey="Leenders, Klaus L" sort="Leenders, Klaus L" uniqKey="Leenders K" first="Klaus L" last="Leenders">Klaus L. Leenders</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Klein, Reinoud C" sort="Klein, Reinoud C" uniqKey="Klein R" first="Reinoud C" last="Klein">Reinoud C. 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