Motor thalamic circuits in primates with emphasis on the area targeted in treatment of movement disorders.
Identifieur interne : 000752 ( Ncbi/Checkpoint ); précédent : 000751; suivant : 000753Motor thalamic circuits in primates with emphasis on the area targeted in treatment of movement disorders.
Auteurs : Igor A. Ilinsky [États-Unis] ; Kristy Kultas-IlinskySource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2002.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Thalamus.
- pathology : Movement Disorders.
- surgery : Neural Pathways, Thalamus.
- therapy : Movement Disorders.
- ultrastructure : Neural Pathways, Thalamus.
- Animals, Humans, Primates, Stereotaxic Techniques, Terminology as Topic.
Abstract
The ventral region of the motor thalamus that receives cerebellar afferents has been and still is the target of stereotactic interventions for movement disorders. According to Hassler, this area includes ventro-oralis posterior (Vop) and ventral intermedius (Vim) nuclei, although some investigators believe that Vop is associated with the pallidothalamic pathway. We sought to correlate our experimental data on distribution of nigral, pallidal, and cerebellar afferents to the monkey thalamus with Hassler's motor thalamic parcelations. We concluded that Hassler's parcelations retained their value, although some adjustments were needed to relate them to the current neuroanatomic data; particularly, the cerebellothalamic zone that represents the monkey ventral lateral nucleus (VL) corresponds topographically to Hassler's Vop, Vim, and most of Voi. Electron microscopic tracing studies have shown very complex circuitry in this region of the monkey thalamus, as the cerebellar and cortical afferents innervating it are engaged in complex synapses with thalamocortical projection neurons, and this interaction is strongly modulated by local circuit neurons and the input from the reticular thalamic nucleus, which are both inhibitory and gamma-aminobutyric acid (GABA)ergic. Spinothalamic afferents also reach the VL, but this input is less studied in the monkey. The circuitry subserving the activity of thalamocortical projection neurons in the VL should be considered while interpreting the functional data obtained in stereotactic surgery.
PubMed: 11948750
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Motor thalamic circuits in primates with emphasis on the area targeted in treatment of movement disorders.</title><author><name sortKey="Ilinsky, Igor A" sort="Ilinsky, Igor A" uniqKey="Ilinsky I" first="Igor A" last="Ilinsky">Igor A. Ilinsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City 52242, USA. igor-ilinsky@uiowa.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City 52242</wicri:regionArea><wicri:noRegion>Iowa City 52242</wicri:noRegion></affiliation></author><author><name sortKey="Kultas Ilinsky, Kristy" sort="Kultas Ilinsky, Kristy" uniqKey="Kultas Ilinsky K" first="Kristy" last="Kultas-Ilinsky">Kristy Kultas-Ilinsky</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:11948750</idno><idno type="pmid">11948750</idno><idno type="wicri:Area/PubMed/Corpus">003A99</idno><idno type="wicri:Area/PubMed/Curation">003A99</idno><idno type="wicri:Area/PubMed/Checkpoint">003A15</idno><idno type="wicri:Area/Ncbi/Merge">000752</idno><idno type="wicri:Area/Ncbi/Curation">000752</idno><idno type="wicri:Area/Ncbi/Checkpoint">000752</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Motor thalamic circuits in primates with emphasis on the area targeted in treatment of movement disorders.</title><author><name sortKey="Ilinsky, Igor A" sort="Ilinsky, Igor A" uniqKey="Ilinsky I" first="Igor A" last="Ilinsky">Igor A. Ilinsky</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City 52242, USA. igor-ilinsky@uiowa.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City 52242</wicri:regionArea><wicri:noRegion>Iowa City 52242</wicri:noRegion></affiliation></author><author><name sortKey="Kultas Ilinsky, Kristy" sort="Kultas Ilinsky, Kristy" uniqKey="Kultas Ilinsky K" first="Kristy" last="Kultas-Ilinsky">Kristy Kultas-Ilinsky</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2002" type="published">2002</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Movement Disorders (pathology)</term><term>Movement Disorders (therapy)</term><term>Neural Pathways (surgery)</term><term>Neural Pathways (ultrastructure)</term><term>Primates</term><term>Stereotaxic Techniques</term><term>Terminology as Topic</term><term>Thalamus (anatomy & histology)</term><term>Thalamus (surgery)</term><term>Thalamus (ultrastructure)</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Neural Pathways</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Neural Pathways</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Primates</term><term>Stereotaxic Techniques</term><term>Terminology as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ventral region of the motor thalamus that receives cerebellar afferents has been and still is the target of stereotactic interventions for movement disorders. According to Hassler, this area includes ventro-oralis posterior (Vop) and ventral intermedius (Vim) nuclei, although some investigators believe that Vop is associated with the pallidothalamic pathway. We sought to correlate our experimental data on distribution of nigral, pallidal, and cerebellar afferents to the monkey thalamus with Hassler's motor thalamic parcelations. We concluded that Hassler's parcelations retained their value, although some adjustments were needed to relate them to the current neuroanatomic data; particularly, the cerebellothalamic zone that represents the monkey ventral lateral nucleus (VL) corresponds topographically to Hassler's Vop, Vim, and most of Voi. Electron microscopic tracing studies have shown very complex circuitry in this region of the monkey thalamus, as the cerebellar and cortical afferents innervating it are engaged in complex synapses with thalamocortical projection neurons, and this interaction is strongly modulated by local circuit neurons and the input from the reticular thalamic nucleus, which are both inhibitory and gamma-aminobutyric acid (GABA)ergic. Spinothalamic afferents also reach the VL, but this input is less studied in the monkey. The circuitry subserving the activity of thalamocortical projection neurons in the VL should be considered while interpreting the functional data obtained in stereotactic surgery.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Kultas Ilinsky, Kristy" sort="Kultas Ilinsky, Kristy" uniqKey="Kultas Ilinsky K" first="Kristy" last="Kultas-Ilinsky">Kristy Kultas-Ilinsky</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Ilinsky, Igor A" sort="Ilinsky, Igor A" uniqKey="Ilinsky I" first="Igor A" last="Ilinsky">Igor A. Ilinsky</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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