Botulinum toxin a improves muscle spasms and rigidity in stiff‐person syndrome
Identifieur interne : 008425 ( Main/Merge ); précédent : 008424; suivant : 008426Botulinum toxin a improves muscle spasms and rigidity in stiff‐person syndrome
Auteurs : Liguori [Italie] ; Carla Cordivari [Italie] ; Elio Lugaresi [Italie] ; Pasquale Montagna [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 1997-11.
English descriptors
- KwdEn :
- Botulinum Toxins, Type A (therapeutic use), Botulinum toxin A, Female, Humans, Middle Aged, Muscle Rigidity (complications), Muscle Rigidity (drug therapy), Muscle Rigidity (physiopathology), Muscle, Skeletal (physiopathology), Neuromuscular Agents (therapeutic use), Stiff-Person Syndrome (complications), Stiff‐person syndrome.
- MESH :
- chemical , therapeutic use : Botulinum Toxins, Type A, Neuromuscular Agents.
- complications : Muscle Rigidity, Stiff-Person Syndrome.
- drug therapy : Muscle Rigidity.
- physiopathology : Muscle Rigidity, Muscle, Skeletal.
- Female, Humans, Middle Aged.
Abstract
We studied the effect of botulinum toxin A (BTA) on painful muscular spasms and rigidity in two bedridden patients with clinical, electrophysiologic, and immunologic evidence of stiff‐person syndrome. We injected BTA of saline solution into several limb muscles with both the rater and patient blinded to the order of the injections. A physician, unaware of the treatment order, used an objective rating scale for rigidity and spasm frequency scale and independently assessed the treatment results. BTA administration significantly reduced rigidity and stopped the spasms in all limbs. Following BTA injection on one side, the spasm frequency decreased bilaterally possibly because of the spread of hematogenous toxin.
Url:
DOI: 10.1002/mds.870120636
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-11">1997-11</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1060">1060</biblScope><biblScope unit="page" to="1063">1063</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DC07C27470018DF7C54484F10054E37F788473AB</idno><idno type="DOI">10.1002/mds.870120636</idno><idno type="ArticleID">MDS870120636</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Botulinum toxin A</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Muscle Rigidity (complications)</term><term>Muscle Rigidity (drug therapy)</term><term>Muscle Rigidity (physiopathology)</term><term>Muscle, Skeletal (physiopathology)</term><term>Neuromuscular Agents (therapeutic use)</term><term>Stiff-Person Syndrome (complications)</term><term>Stiff‐person syndrome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Muscle Rigidity</term><term>Stiff-Person Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Rigidity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle Rigidity</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Middle Aged</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the effect of botulinum toxin A (BTA) on painful muscular spasms and rigidity in two bedridden patients with clinical, electrophysiologic, and immunologic evidence of stiff‐person syndrome. We injected BTA of saline solution into several limb muscles with both the rater and patient blinded to the order of the injections. A physician, unaware of the treatment order, used an objective rating scale for rigidity and spasm frequency scale and independently assessed the treatment results. BTA administration significantly reduced rigidity and stopped the spasms in all limbs. Following BTA injection on one side, the spasm frequency decreased bilaterally possibly because of the spread of hematogenous toxin.</div></front></TEI><double doi="10.1002/mds.870120636"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Botulinum toxin a improves muscle spasms and rigidity in stiff‐person syndrome</title><author><name sortKey="Liguori" sort="Liguori" uniqKey="Liguori" last="Liguori">Liguori</name></author><author><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name></author><author><name sortKey="Lugaresi, Elio" sort="Lugaresi, Elio" uniqKey="Lugaresi E" first="Elio" last="Lugaresi">Elio Lugaresi</name></author><author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:DC07C27470018DF7C54484F10054E37F788473AB</idno><date when="1997" year="1997">1997</date><idno type="doi">10.1002/mds.870120636</idno><idno type="url">https://api.istex.fr/document/DC07C27470018DF7C54484F10054E37F788473AB/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003244</idno><idno type="wicri:Area/Istex/Curation">003244</idno><idno type="wicri:Area/Istex/Checkpoint">003A20</idno><idno type="wicri:doubleKey">0885-3185:1997:Liguori:botulinum:toxin:a</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Botulinum toxin a improves muscle spasms and rigidity in stiff‐person syndrome</title><author><name sortKey="Liguori" sort="Liguori" uniqKey="Liguori" last="Liguori">Liguori</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Cordivari, Carla" sort="Cordivari, Carla" uniqKey="Cordivari C" first="Carla" last="Cordivari">Carla Cordivari</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Lugaresi, Elio" sort="Lugaresi, Elio" uniqKey="Lugaresi E" first="Elio" last="Lugaresi">Elio Lugaresi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Montagna, Pasquale" sort="Montagna, Pasquale" uniqKey="Montagna P" first="Pasquale" last="Montagna">Pasquale Montagna</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1997-11">1997-11</date><biblScope unit="vol">12</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="1060">1060</biblScope><biblScope unit="page" to="1063">1063</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">DC07C27470018DF7C54484F10054E37F788473AB</idno><idno type="DOI">10.1002/mds.870120636</idno><idno type="ArticleID">MDS870120636</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Botulinum toxin A</term><term>Stiff‐person syndrome</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the effect of botulinum toxin A (BTA) on painful muscular spasms and rigidity in two bedridden patients with clinical, electrophysiologic, and immunologic evidence of stiff‐person syndrome. We injected BTA of saline solution into several limb muscles with both the rater and patient blinded to the order of the injections. A physician, unaware of the treatment order, used an objective rating scale for rigidity and spasm frequency scale and independently assessed the treatment results. BTA administration significantly reduced rigidity and stopped the spasms in all limbs. Following BTA injection on one side, the spasm frequency decreased bilaterally possibly because of the spread of hematogenous toxin.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Botulinum toxin A improves muscle spasms and rigidity in stiff-person syndrome.</title><author><name sortKey="Liguori, R" sort="Liguori, R" uniqKey="Liguori R" first="R" last="Liguori">R. Liguori</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurology, University of Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Cordivari, C" sort="Cordivari, C" uniqKey="Cordivari C" first="C" last="Cordivari">C. Cordivari</name></author><author><name sortKey="Lugaresi, E" sort="Lugaresi, E" uniqKey="Lugaresi E" first="E" last="Lugaresi">E. Lugaresi</name></author><author><name sortKey="Montagna, P" sort="Montagna, P" uniqKey="Montagna P" first="P" last="Montagna">P. Montagna</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9399238</idno><idno type="pmid">9399238</idno><idno type="doi">10.1002/mds.870120636</idno><idno type="wicri:Area/PubMed/Corpus">004543</idno><idno type="wicri:Area/PubMed/Curation">004543</idno><idno type="wicri:Area/PubMed/Checkpoint">004708</idno><idno type="wicri:Area/Ncbi/Merge">004E42</idno><idno type="wicri:Area/Ncbi/Curation">004E42</idno><idno type="wicri:Area/Ncbi/Checkpoint">004E42</idno><idno type="wicri:doubleKey">0885-3185:1997:Liguori R:botulinum:toxin:a</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Botulinum toxin A improves muscle spasms and rigidity in stiff-person syndrome.</title><author><name sortKey="Liguori, R" sort="Liguori, R" uniqKey="Liguori R" first="R" last="Liguori">R. Liguori</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Neurology, University of Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neurology, University of Bologna</wicri:regionArea><wicri:noRegion>University of Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Cordivari, C" sort="Cordivari, C" uniqKey="Cordivari C" first="C" last="Cordivari">C. Cordivari</name></author><author><name sortKey="Lugaresi, E" sort="Lugaresi, E" uniqKey="Lugaresi E" first="E" last="Lugaresi">E. Lugaresi</name></author><author><name sortKey="Montagna, P" sort="Montagna, P" uniqKey="Montagna P" first="P" last="Montagna">P. Montagna</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Botulinum Toxins, Type A (therapeutic use)</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Muscle Rigidity (complications)</term><term>Muscle Rigidity (drug therapy)</term><term>Muscle Rigidity (physiopathology)</term><term>Muscle, Skeletal (physiopathology)</term><term>Neuromuscular Agents (therapeutic use)</term><term>Stiff-Person Syndrome (complications)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Botulinum Toxins, Type A</term><term>Neuromuscular Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Muscle Rigidity</term><term>Stiff-Person Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Muscle Rigidity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle Rigidity</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the effect of botulinum toxin A (BTA) on painful muscular spasms and rigidity in two bedridden patients with clinical, electrophysiologic, and immunologic evidence of stiff-person syndrome. We injected BTA or saline solution into several limb muscles with both the rater and patient blinded to the order of the injections. A physician, unaware of the treatment order, used an objective rating scale for rigidity and spasm frequency scale and independently assessed the treatment results. BTA administration significantly reduced rigidity and stopped the spasms in all limbs. Following BTA injection on one side, the spasm frequency decreased bilaterally possibly because of the spread of hematogenous toxin.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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